{"id":5164,"date":"2025-11-17T16:46:57","date_gmt":"2025-11-17T13:46:57","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5164"},"modified":"2025-11-17T17:27:48","modified_gmt":"2025-11-17T14:27:48","slug":"ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/pt\/ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye\/","title":{"rendered":"Ali Taghizadeh anuncia terapia com mRNA ANKA para DMD, atualmente em ensaio cl\u00ednico na Turquia."},"content":{"rendered":"<p class=\"wp-block-paragraph\">O farmacologista turco, Prof. Dr. Ali Taghizadeh, anunciou em ingl\u00eas aos seus seguidores no exterior a terapia de mRNA na qual est\u00e1 trabalhando para a distrofia muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O professor associado Dr. Ali Taghizadeh compartilhou um v\u00eddeo informativo em ingl\u00eas em sua conta do Instagram sobre a DMD ANKA, a terapia de mRNA que ele desenvolveu para a distrofia muscular de Duchenne. <strong>Saber mais<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/pt\/mrna-duchenne-muscular-dystrophy-dmd-treatment\/\" target=\"_blank\" rel=\"noreferrer noopener\">Estudos de mRNA no tratamento de DMD: futuros candidatos terap\u00eauticos<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">O que significa ANKA?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ANKA \u00e9 uma criatura mitol\u00f3gica que significa P\u00e1ssaro Anka em turco e \u00e9 conhecida como F\u00eanix em ingl\u00eas.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Introdu\u00e7\u00e3o \u00e0 DMD ANKA<\/h2>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-captioned data-instgrm-permalink=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">Bu g\u00f6nderiyi Instagram&#039;da gor<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">DMD Hastal\u0131\u011f\u0131, Ali Taghizadeh (@alitgzd)&#039;in payla\u015ft\u0131\u011f\u0131 bir g\u00f6nderi<\/a><\/p><\/div><\/blockquote>\n<script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Segue o texto completo do v\u00eddeo:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ol\u00e1 a todos, meu nome \u00e9 Ali Taghizadeh.<br>Eu sou da Universidade Bilecik \u015eeyh Edebali.<br>Sou professor associado de Farmacologia M\u00e9dica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gostaria de apresentar o nosso DMD ANKA para estrangeiros que vivem fora da Turquia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Podemos avaliar a DMD ANKA em tr\u00eas t\u00f3picos diferentes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A primeira \u00e9 a sequ\u00eancia de mRNA que usamos no DMD ANKA.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Como voc\u00ea sabe, a distrofina \u00e9 a maior prote\u00edna do corpo, com a maior sequ\u00eancia de mRNA.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">S\u00e3o quase quinze mil mol\u00e9culas de fosfato, e estabiliz\u00e1-las \u00e9 muito dif\u00edcil, o que representa um grande desafio para os cientistas. Agora, somos capazes de produzir e estabilizar o fosfato sem o uso de produtos qu\u00edmicos ou subst\u00e2ncias perigosas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Na segunda etapa, queremos saber se a DMD ANKA est\u00e1 envolvida nos ciclos celulares ou na fisiologia celular.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Isso significa que, quando administramos DMD ANKA ao paciente, queremos que o DMD ANKA passe pela corrente sangu\u00ednea e chegue \u00e0s c\u00e9lulas. L\u00e1, ap\u00f3s ser direcionado para as c\u00e9lulas, elas o reconhecem fisiologicamente como um produto gerado a partir do DNA. Esse mRNA \u00e9 traduzido em prote\u00edna pelo sistema reticuloendoplasm\u00e1tico (Ras) e, em seguida, \u00e9 localizado dentro das c\u00e9lulas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nosso terceiro passo \u00e9 o in\u00edcio da recupera\u00e7\u00e3o e regenera\u00e7\u00e3o das c\u00e9lulas desde as primeiras horas, com o envolvimento do nosso mRNA na fisiologia celular.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c9 muito importante porque, quando queremos dar um passo com uma distrofina funcional, precisamos entender que ela \u00e9 o nosso mRNA e que vamos traduzi-lo em prote\u00edna, enviando-a para a membrana para que ela fa\u00e7a seu trabalho e seja processada pela c\u00e9lula.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00c9 muito importante porque a fibrose e todos os processos inflamat\u00f3rios s\u00e3o realizados pelas c\u00e9lulas do corpo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Quando queremos acabar com a fibrose e a inflama\u00e7\u00e3o, precisamos fazer isso de uma forma que envolva interagir com as c\u00e9lulas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Isso significa que, ap\u00f3s a distrofina ser localizada na membrana e se ligar aos distroglicanos e sarcoglicanos, ao inspecionar e \u00e0 actina alfa aferente e oferecer aos antineur\u00f4nios, o arco entre o m\u00fasculo e o c\u00e9rebro \u00e9 reconstru\u00eddo, se recupera, se regenera e, por meio disso, a fibrose \u00e9 eliminada, iniciando-se assim o processo de elimina\u00e7\u00e3o da fibrose.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Para n\u00f3s, isso \u00e9 importante porque o DMD ANKA pode ser usado tanto em adultos quanto em crian\u00e7as com distrofia muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Siga esta p\u00e1gina<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/pt\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Todos os ensaios cl\u00ednicos para distrofia muscular de Duchenne<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Turkish pharmacologist Assoc. Prof. Dr. Ali Taghizadeh announced in English to his followers abroad the mRNA therapy he is working on for Duchenne Muscular Dystrophy. Associate Professor Dr. Ali Taghizadeh shared an English-language information video on his Instagram account about DMD ANKA, the mRNA therapy he developed for Duchenne muscular dystrophy. Learn More: mRNA Studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5165,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[345,333,359,202,455],"class_list":["post-5164","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-ali-taghizadeh","tag-dmd-anka","tag-full-length-dystrophin","tag-mrna","tag-mrna-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/5164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/comments?post=5164"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/5164\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media\/5165"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media?parent=5164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/categories?post=5164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/tags?post=5164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}