{"id":2162,"date":"2025-01-01T12:34:10","date_gmt":"2025-01-01T09:34:10","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2162"},"modified":"2025-01-01T12:34:11","modified_gmt":"2025-01-01T09:34:11","slug":"new-research-c-terminal-ct-domain-between-dystrophin-and-dystrobrevin","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/pt\/new-research-c-terminal-ct-domain-between-dystrophin-and-dystrobrevin\/","title":{"rendered":"Novas pesquisas sobre intera\u00e7\u00f5es de prote\u00ednas na distrofia muscular de Duchenne levam a terapias mais direcionadas"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Uma descoberta pioneira mostrou as rela\u00e7\u00f5es complicadas entre a distrofina, uma prote\u00edna de estabilidade muscular, e sua prote\u00edna companheira, a distrobrevina, abrindo novos caminhos para o estudo e tratamento da Distrofia Muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pesquisadores descrevem a regi\u00e3o C-terminal (CT) cr\u00edptica da distrofina e seu papel na manuten\u00e7\u00e3o das membranas celulares nos tecidos no Journal of Biological Chemistry de dezembro.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cEsta pesquisa destaca a din\u00e2mica intrincada das intera\u00e7\u00f5es da distrofina e da distrobrevina, fornecendo insights cr\u00edticos que podem informar o desenvolvimento futuro do tratamento\u201d, disse o autor principal do estudo, Krishna Mallela, professor da Escola de Farm\u00e1cia e Ci\u00eancias Farmac\u00eauticas Skaggs da Universidade do Colorado. Nossa compreens\u00e3o de como essas prote\u00ednas funcionam em diversos tecidos est\u00e1 um passo mais perto de encontrar tratamentos para DMD que visem as causas raiz.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/news.cuanschutz.edu\/news-stories\/new-study-uncovers-key-insights-into-protein-interactions-in-duchenne-muscular-dystrophy-paving-way-for-more-targeted-therapies\" target=\"_blank\" rel=\"noreferrer noopener\">Ler mais<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(24)02504-3\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">Link de pesquisa<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A pioneering discovery has shown the complicated relationships between dystrophin, a muscle stability protein, and its companion protein, dystrobrevin, opening new avenues for studying and treating Duchenne Muscular Dystrophy. Researchers describe dystrophin cryptic C-terminal (CT) region and its role in maintaining cellular membranes across tissues in the December Journal of Biological Chemistry. \u201cThis research highlights [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2166,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[66,74,73,61],"class_list":["post-2162","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-duchenne-muscular-dystrophy","tag-dystrobrevin","tag-dystrophin","tag-gene-therapy"],"subtitle":"Os resultados do estudo explicam como a distrofina funciona molecularmente, revelando como os medicamentos para distrofia muscular podem ser desenvolvidos.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/2162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/comments?post=2162"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/2162\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media\/2166"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media?parent=2162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/categories?post=2162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/tags?post=2162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}