{"id":2159,"date":"2024-12-30T16:44:16","date_gmt":"2024-12-30T13:44:16","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2159"},"modified":"2024-12-30T16:46:51","modified_gmt":"2024-12-30T13:46:51","slug":"zebrafish-modeling-shows-promise-in-duchenne-dmd-research","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/pt\/zebrafish-modeling-shows-promise-in-duchenne-dmd-research\/","title":{"rendered":"Modelagem de peixe-zebra mostra-se promissora na pesquisa de Duchenne (DMD)"},"content":{"rendered":"<p class=\"wp-block-paragraph\">O peixe-zebra (Danio rerio) surgiu como um organismo modelo valioso para investigar o desenvolvimento musculoesquel\u00e9tico e a fisiopatologia de doen\u00e7as associadas. Genes-chave e processos biol\u00f3gicos no peixe-zebra s\u00e3o muito semelhantes aos dos humanos, e o desenvolvimento r\u00e1pido e os embri\u00f5es transparentes tornam o peixe-zebra ideal para estudos in vivo da forma\u00e7\u00e3o \u00f3ssea e muscular, bem como os mecanismos moleculares subjacentes aos dist\u00farbios musculoesquel\u00e9ticos.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A pesquisa est\u00e1 se concentrando na utilidade do peixe-zebra na modelagem de v\u00e1rios dist\u00farbios musculoesquel\u00e9ticos, com \u00eanfase particular em doen\u00e7as \u00f3sseas, como osteoporose e osteog\u00eanese imperfeita, e dist\u00farbios musculares, como distrofia muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/2073-4409\/14\/1\/28\" target=\"_blank\" rel=\"noreferrer noopener\">Ler mais<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Zebrafish (Danio rerio) has emerged as a valuable model organism for investigating musculoskeletal development and the pathophysiology of associated diseases. Key genes and biological processes in zebrafish are very similar to those in humans, and the rapid development and transparent embryos make zebrafish ideal for in vivo studies of bone and muscle formation as well [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2160,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[70,72,71],"class_list":["post-2159","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-crispr-cas9","tag-gene-editing","tag-zebrafish"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/2159","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/comments?post=2159"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/2159\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media\/2160"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media?parent=2159"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/categories?post=2159"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/tags?post=2159"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}