{"id":1957,"date":"2024-12-24T21:03:48","date_gmt":"2024-12-24T18:03:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=1957"},"modified":"2024-12-24T21:03:50","modified_gmt":"2024-12-24T18:03:50","slug":"splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/pt\/splicer-gene-editing-tool-holds-a-lot-of-potential-to-treat-duchenne-muscular-dystrophy\/","title":{"rendered":"Ferramenta de edi\u00e7\u00e3o gen\u00e9tica SPLICER tem grande potencial para tratar distrofia muscular de Duchenne"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Uma nova ferramenta de edi\u00e7\u00e3o gen\u00e9tica que ajuda a maquinaria celular a pular partes de genes respons\u00e1veis por doen\u00e7as foi aplicada para reduzir a forma\u00e7\u00e3o de precursores de placas beta-amiloides em um modelo murino de doen\u00e7a de Alzheimer, relatam pesquisadores da Universidade de Illinois Urbana-Champaign.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">O SPLICER usa uma abordagem de edi\u00e7\u00e3o gen\u00e9tica chamada salto de exon, que \u00e9 de particular interesse para condi\u00e7\u00f5es de sa\u00fade causadas por muta\u00e7\u00f5es que produzem prote\u00ednas mal dobradas ou t\u00f3xicas, como distrofia muscular de Duchenne ou doen\u00e7a de Huntington.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Perez-Pinera, um professor de bioengenharia, disse: \u201cMas para doen\u00e7as como Alzheimer, Parkinson, Huntington ou distrofia muscular de Duchenne, essa abordagem tem muito potencial. O pr\u00f3ximo passo imediato \u00e9 analisar a seguran\u00e7a da remo\u00e7\u00e3o dos exons alvos nessas doen\u00e7as e garantir que n\u00e3o estamos criando uma nova prote\u00edna que seja t\u00f3xica ou que n\u00e3o tenha uma fun\u00e7\u00e3o-chave. Tamb\u00e9m precisar\u00edamos fazer estudos em animais de longo prazo e ver se a doen\u00e7a progride ao longo do tempo.\u201d<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-54529-y\" target=\"_blank\" rel=\"noreferrer noopener\">Ler mais<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer&#8217;s disease, researchers at the University of Illinois Urbana-Champaign report. SPLICER uses a gene editing approach called exon skipping, which is of particular [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1959,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[59,60],"class_list":["post-1957","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-splicer","tag-splicer-gene-editing"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/1957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/comments?post=1957"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/posts\/1957\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media\/1959"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/media?parent=1957"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/categories?post=1957"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/pt\/wp-json\/wp\/v2\/tags?post=1957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}