{"id":6747,"date":"2026-03-12T11:43:48","date_gmt":"2026-03-12T08:43:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=6747"},"modified":"2026-06-24T22:01:09","modified_gmt":"2026-06-24T19:01:09","slug":"del-zota-phase-3-safari44-clinical-trial-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/del-zota-phase-3-safari44-clinical-trial-duchenne-muscular-dystrophy\/","title":{"rendered":"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f Del-Zota \u092b\u0947\u091c 3 SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932: \u0905\u0927\u094d\u092f\u092f\u0928 \u0921\u093f\u091c\u093e\u0907\u0928, \u0921\u0947\u091f\u093e \u0914\u0930 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092e\u0939\u0924\u094d\u0935"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f del-zota \u091a\u0930\u0923 3 SAFARI44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928-44-\u0905\u0928\u0941\u0915\u0942\u0932 \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0935\u093e\u0932\u0947 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0932\u0915\u094d\u0937\u093f\u0924 \u0909\u092a\u091a\u093e\u0930 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0926\u093f\u0936\u093e \u092e\u0947\u0902 \u090f\u0915 \u092c\u0921\u093c\u093e \u0915\u0926\u092e \u0939\u0948\u0964. <\/strong>\u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902: <a href=\"https:\/\/dmdwarrior.com\/hi\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u090f\u0938\u094b\u0938\u093f\u090f\u0936\u0928 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u090f\u0902\u0921 \u0938\u093e\u0907\u0902\u091f\u093f\u092b\u093f\u0915 \u0915\u0949\u0928\u094d\u092b\u094d\u0930\u0947\u0902\u0938 \u092e\u0947\u0902 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924, SAFARI44 \u0905\u0927\u094d\u092f\u092f\u0928 Avidity Biosciences \u0926\u094d\u0935\u093e\u0930\u093e \u0935\u093f\u0915\u0938\u093f\u0924 \u090f\u0915 \u092a\u094d\u0930\u093e\u092f\u094b\u0917\u093f\u0915 \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940-\u0913\u0932\u093f\u0917\u094b\u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u094b\u091f\u093e\u0907\u0921 \u0938\u0902\u092f\u0941\u0917\u094d\u092e (AOC) \u0925\u0947\u0930\u0947\u092a\u0940 del-zota \u0915\u0940 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u092a\u094d\u0930\u092d\u093e\u0935\u0936\u0940\u0932\u0924\u093e \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0924\u093e \u0939\u0948\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0924\u0940\u0938\u0930\u0947 \u091a\u0930\u0923 \u0915\u093e \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0909\u0924\u094d\u0938\u093e\u0939\u091c\u0928\u0915 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 \u0915\u0947 \u0906\u0902\u0915\u0921\u093c\u094b\u0902 \u092a\u0930 \u0906\u0927\u093e\u0930\u093f\u0924 \u0939\u0948, \u091c\u093f\u0938\u092e\u0947\u0902 \u0926\u093f\u0916\u093e\u092f\u093e \u0917\u092f\u093e \u0939\u0948 \u0915\u093f del-zota \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0915\u0947 \u0915\u093e\u0930\u0923 \u0939\u094b\u0928\u0947 \u0935\u093e\u0932\u0947 DMD \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0914\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0915\u093e\u0930\u094d\u092f \u092e\u0947\u0902 \u0909\u0932\u094d\u0932\u0947\u0916\u0928\u0940\u092f \u0938\u0941\u0927\u093e\u0930 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#key-highlights-of-the-safari-44-phase-3-trial\">SAFARI44 \u092b\u0947\u091c 3 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u094d\u092f\u093e \u0939\u0948?<\/a><\/li><li><a href=\"#primary-and-secondary-endpoints\">\u092a\u094d\u0930\u093e\u0925\u092e\u093f\u0915 \u0914\u0930 \u092e\u093e\u0927\u094d\u092f\u092e\u093f\u0915 \u0932\u0915\u094d\u0937\u094d\u092f<\/a><\/li><li><a href=\"#mechanism-of-del-zota-therapy\">Del-Zota \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0940 \u0915\u093e\u0930\u094d\u092f\u092a\u094d\u0930\u0923\u093e\u0932\u0940<\/a><\/li><li><a href=\"#earlier-clinical-data-explore-44-trial\">\u092a\u0942\u0930\u094d\u0935 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0921\u0947\u091f\u093e: EXPLORE44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/a><ul><li><a href=\"#key-findings-from-explore-44\">EXPLORE44 \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u092e\u0941\u0916\u094d\u092f \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937<\/a><\/li><\/ul><\/li><li><a href=\"#open-label-extension-ole-results\">\u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u090f\u0915\u094d\u0938\u091f\u0947\u0902\u0936\u0928 (\u0913\u090f\u0932\u0908) \u092a\u0930\u093f\u0923\u093e\u092e<\/a><\/li><li><a href=\"#safety-and-tolerability\">\u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e<\/a><\/li><li><a href=\"#why-the-safari-44-trial-matters\">SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u094d\u092f\u094b\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948?<\/a><\/li><li><a href=\"#in-which-countries-will-the-del-zota-phase-3-safari-44-clinical-trials-begin\">Del-Zota \u092b\u0947\u091c 3 SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u093f\u0928 \u0926\u0947\u0936\u094b\u0902 \u092e\u0947\u0902 \u0936\u0941\u0930\u0942 \u0939\u094b\u0902\u0917\u0947?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"key-highlights-of-the-safari-44-phase-3-trial\" class=\"wp-block-heading\">SAFARI44 \u092b\u0947\u091c 3 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u094d\u092f\u093e \u0939\u0948?<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0932\u0917\u092d\u0917 70 \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e \u092e\u0930\u0940\u091c, \u091c\u093f\u0928\u0915\u0940 \u0909\u092e\u094d\u0930 2 \u0935\u0930\u094d\u0937 \u092f\u093e \u0909\u0938\u0938\u0947 \u0905\u0927\u093f\u0915 \u0939\u0948, \u0907\u0938 \u0905\u0927\u094d\u092f\u092f\u0928 \u092e\u0947\u0902 \u092d\u093e\u0917 \u0932\u0947\u0902\u0917\u0947\u0964.<\/strong><\/li>\n\n\n\n<li>\u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u094b 54 \u0938\u092a\u094d\u0924\u093e\u0939 \u0924\u0915 \u0939\u0930 \u091b\u0939 \u0938\u092a\u094d\u0924\u093e\u0939 \u092e\u0947\u0902 \u0905\u0902\u0924\u0903\u0936\u093f\u0930\u093e \u0926\u094d\u0935\u093e\u0930\u093e \u0926\u0935\u093e \u0926\u0940 \u091c\u093e\u090f\u0917\u0940\u0964.<\/li>\n\n\n\n<li><strong>\u0907\u0938 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902:<\/strong>\n<ul class=\"wp-block-list\">\n<li>\u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915 \u0921\u092c\u0932-\u092c\u094d\u0932\u093e\u0907\u0902\u0921 \u0909\u092a\u091a\u093e\u0930 \u091a\u0930\u0923 (54 \u0938\u092a\u094d\u0924\u093e\u0939)<\/li>\n\n\n\n<li><strong>\u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u090f\u0915\u094d\u0938\u091f\u0947\u0902\u0936\u0928 (54 \u0938\u092a\u094d\u0924\u093e\u0939)<\/strong><\/li>\n\n\n\n<li>\u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0938\u0902\u092c\u0902\u0927\u0940 \u0905\u0928\u0941\u0935\u0930\u094d\u0924\u0940 \u0915\u093e\u0930\u094d\u0930\u0935\u093e\u0908 (6 \u0938\u092a\u094d\u0924\u093e\u0939)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>\u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u094b 1:1 \u0915\u0947 \u0905\u0928\u0941\u092a\u093e\u0924 \u092e\u0947\u0902 \u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 del-zota 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0932\u094b\u0917\u094d\u0930\u093e\u092e \u092a\u0940\u090f\u092e\u0913 (\u0915\u0941\u0932 \u090f\u0913\u0938\u0940 \u0935\u091c\u0928 28 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0932\u094b\u0917\u094d\u0930\u093e\u092e) \u092f\u093e \u092a\u094d\u0932\u0947\u0938\u0940\u092c\u094b \u0926\u093f\u092f\u093e \u091c\u093e\u090f\u0917\u093e\u0964.<\/strong><\/li>\n\n\n\n<li>\u092c\u094d\u0932\u093e\u0907\u0902\u0921\u0947\u0921 \u091f\u094d\u0930\u0940\u091f\u092e\u0947\u0902\u091f \u0905\u0935\u0927\u093f \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u0915\u0941\u0932 \u0928\u094c \u092c\u093e\u0930 \u0907\u0928\u094d\u092b\u094d\u092f\u0942\u091c\u0928 \u0926\u093f\u092f\u093e \u091c\u093e\u090f\u0917\u093e\u0964.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0907\u0938 \u0921\u093f\u091c\u093e\u0907\u0928 \u0915\u093e \u0909\u0926\u094d\u0926\u0947\u0936\u094d\u092f \u092f\u0939 \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u093f\u0924 \u0915\u0930\u0928\u093e \u0939\u0948 \u0915\u093f \u0915\u094d\u092f\u093e del-zota \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0915\u093e\u0930\u094d\u092f \u0914\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092e\u0947\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u0941\u0927\u093e\u0930 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u094b \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f \u092a\u094d\u0930\u092e\u0941\u0916 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0932\u0915\u094d\u0937\u094d\u092f \u0939\u0948\u0902\u0964.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"primary-and-secondary-endpoints\" class=\"wp-block-heading\">\u092a\u094d\u0930\u093e\u0925\u092e\u093f\u0915 \u0914\u0930 \u092e\u093e\u0927\u094d\u092f\u092e\u093f\u0915 \u0932\u0915\u094d\u0937\u094d\u092f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>del-zota \u092b\u0947\u091c 3 SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u093e \u092a\u094d\u0930\u093e\u0925\u092e\u093f\u0915 \u0932\u0915\u094d\u0937\u094d\u092f \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0939\u0948:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0938\u092e\u092f-\u0938\u0947-\u0935\u0943\u0926\u094d\u0927\u093f \u0935\u0947\u0917 \u092e\u0947\u0902 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928<\/strong>: \u0928\u093f\u091a\u0932\u0947 \u0905\u0902\u0917\u094b\u0902 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0940 \u0924\u093e\u0915\u0924 \u0915\u094b \u0926\u0930\u094d\u0936\u093e\u0928\u0947 \u0935\u093e\u0932\u093e \u090f\u0915 \u0935\u094d\u092f\u093e\u092a\u0915 \u0930\u0942\u092a \u0938\u0947 \u0909\u092a\u092f\u094b\u0917 \u0915\u093f\u092f\u093e \u091c\u093e\u0928\u0947 \u0935\u093e\u0932\u093e \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u092e\u093e\u092a\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0926\u094d\u0935\u093f\u0924\u0940\u092f\u0915 \u092a\u0930\u093f\u0923\u093e\u092e \u092e\u093e\u092a\u094b\u0902 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (\u0938\u0940\u0915\u0947) \u0938\u094d\u0924\u0930<\/strong><\/li>\n\n\n\n<li><strong>4-\u0938\u0940\u0922\u093c\u0940 \u091a\u0922\u093c\u0928\u0947 \u0915\u0940 \u0917\u0924\u093f<\/strong><\/li>\n\n\n\n<li><strong>10 \u092e\u0940\u091f\u0930 \u092a\u0948\u0926\u0932 \u091a\u0932\u0928\u0947\/\u0926\u094c\u0921\u093c\u0928\u0947 \u0915\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/strong><\/li>\n\n\n\n<li><strong>SV95C \u0938\u094d\u091f\u094d\u0930\u093e\u0907\u0921 \u0935\u0947\u0932\u094b\u0938\u093f\u091f\u0940<\/strong><\/li>\n\n\n\n<li><strong>\u0928\u0949\u0930\u094d\u0925 \u0938\u094d\u091f\u093e\u0930 \u090f\u0902\u092c\u0941\u0932\u0947\u091f\u0930\u0940 \u0905\u0938\u0947\u0938\u092e\u0947\u0902\u091f (\u090f\u0928\u090f\u0938\u090f\u090f)<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0907\u0928 \u092e\u093e\u092a\u0926\u0902\u0921\u094b\u0902 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0906\u092e\u0924\u094c\u0930 \u092a\u0930 \u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u092e\u0947\u0902 \u0930\u094b\u0917 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u0914\u0930 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0938\u0941\u0927\u093e\u0930 \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0915\u093f\u092f\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/hi\/biomarkers-in-duchenne-muscular-dystrophy\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u0940\u090f\u092e\u0921\u0940 \u092e\u0947\u0902 \u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"mechanism-of-del-zota-therapy\" class=\"wp-block-heading\">Del-Zota \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0940 \u0915\u093e\u0930\u094d\u092f\u092a\u094d\u0930\u0923\u093e\u0932\u0940<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e \u090f\u0915 \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940-\u0913\u0932\u093f\u0917\u094b\u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u094b\u091f\u093e\u0907\u0921 \u0915\u0902\u091c\u0941\u0917\u0947\u091f (\u090f\u0913\u0938\u0940) \u0939\u0948 \u091c\u093f\u0938\u0947 \u092b\u0949\u0938\u094d\u092b\u094b\u0930\u094b\u0921\u093e\u092f\u092e\u093e\u0907\u0921\u0947\u091f \u092e\u0949\u0930\u094d\u092b\u094b\u0932\u093f\u0928\u094b \u0913\u0932\u093f\u0917\u094b\u092e\u0930\u094d\u0938 (\u092a\u0940\u090f\u092e\u0913) \u0915\u094b \u0938\u0940\u0927\u0947 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u090a\u0924\u0915 \u0924\u0915 \u092a\u0939\u0941\u0902\u091a\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948\u0964.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0907\u0938 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u093e \u0909\u0926\u094d\u0926\u0947\u0936\u094d\u092f \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0939\u0948:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u091c\u0940\u0928 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0915\u094b \u091b\u094b\u0921\u093c \u0926\u0947\u0902<\/strong><\/li>\n\n\n\n<li><strong>\u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 mRNA \u0915\u0947 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u0915\u094b \u092a\u0941\u0928\u0930\u094d\u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0915\u0930\u0947\u0902<\/strong><\/li>\n\n\n\n<li><strong>\u090f\u0915 \u091b\u094b\u091f\u0947 \u0932\u0947\u0915\u093f\u0928 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u0947 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u0938\u0915\u094d\u0937\u092e \u0915\u0930\u0947\u0902<\/strong><\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0939 \u0930\u0923\u0928\u0940\u0924\u093f \u0909\u0928 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0930\u0947\u0936\u094b\u0902 \u0915\u094b \u0938\u094d\u0925\u093f\u0930 \u0915\u0930\u0928\u0947 \u0914\u0930 \u0930\u094b\u0917 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u094b \u0927\u0940\u092e\u093e \u0915\u0930\u0928\u0947 \u092e\u0947\u0902 \u092e\u0926\u0926 \u0915\u0930 \u0938\u0915\u0924\u0940 \u0939\u0948 \u091c\u093f\u0928\u0915\u0947 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u090f\u0915\u094d\u0938\u0949\u0928-\u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0939\u0948\u0902\u0964.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"earlier-clinical-data-explore-44-trial\" class=\"wp-block-heading\">\u092a\u0942\u0930\u094d\u0935 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0921\u0947\u091f\u093e: EXPLORE44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EXPLORE44 \u0905\u0927\u094d\u092f\u092f\u0928, EXPLORE44 \u091a\u0930\u0923 1\/2 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e\u094b\u0902 \u092a\u0930 \u0906\u0927\u093e\u0930\u093f\u0924 \u0939\u0948, \u091c\u093f\u0938\u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928-44-\u0909\u092a\u091a\u093e\u0930 \u092f\u094b\u0917\u094d\u092f \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0935\u093e\u0932\u0947 26 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u0940 \u0936\u093e\u092e\u093f\u0932 \u0925\u0947\u0964.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"968\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg\" alt=\"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928\" class=\"wp-image-5275\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg 968w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-284x300.jpg 284w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-768x813.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1452x1536.jpg 1452w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-11x12.jpg 11w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-397x420.jpg 397w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-150x159.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-300x317.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-696x737.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1068x1130.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping.jpg 1890w\" sizes=\"(max-width: 968px) 100vw, 968px\" \/><\/figure>\n\n\n\n<h3 id=\"key-findings-from-explore-44\" class=\"wp-block-heading\">EXPLORE44 \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u092e\u0941\u0916\u094d\u092f \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0906\u0902\u0915\u0921\u093c\u094b\u0902 \u0938\u0947 \u092f\u0939 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0939\u0941\u0906:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0915\u0902\u0915\u093e\u0932 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 PMO \u0915\u0940 \u0938\u093e\u0902\u0926\u094d\u0930\u0924\u093e \u0932\u0917\u092d\u0917 200 nM \u0939\u094b\u0924\u0940 \u0939\u0948\u0964<\/strong><\/li>\n\n\n\n<li><strong>\u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0938\u094d\u0924\u0930\u094b\u0902 \u0915\u093e ~25%<\/strong><\/li>\n\n\n\n<li><strong>37% \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928-44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u092e\u0947\u0902 \u0935\u0943\u0926\u094d\u0927\u093f<\/strong><\/li>\n\n\n\n<li><strong>&gt;80% \u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c \u092e\u0947\u0902 \u0915\u092e\u0940<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0935\u093e\u0932\u0947 \u0938\u092e\u0942\u0939\u094b\u0902 \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u092a\u0930\u093f\u0923\u093e\u092e \u092d\u0940 \u0909\u0924\u094d\u0938\u093e\u0939\u091c\u0928\u0915 \u0930\u0939\u0947\u0964 \u0914\u0930 \u092a\u0922\u093c\u0947\u0902: <a href=\"https:\/\/dmdwarrior.com\/hi\/del-zota-explore44-provides-nearly-30-normal-dystrophin-production-in-patients-amenable-to-exon-44-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e (EXPLORE44) \u0932\u0917\u092d\u0917 30% \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u093e \u0939\u0948<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"open-label-extension-ole-results\" class=\"wp-block-heading\">\u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u090f\u0915\u094d\u0938\u091f\u0947\u0902\u0936\u0928 (\u0913\u090f\u0932\u0908) \u092a\u0930\u093f\u0923\u093e\u092e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u090f\u0915\u094d\u0938\u091f\u0947\u0902\u0936\u0928 \u092e\u0947\u0902 \u0909\u092a\u091a\u093e\u0930 \u091c\u093e\u0930\u0940 \u0930\u0916\u0928\u0947 \u0935\u093e\u0932\u0947 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0928\u0947 12-24 \u092e\u0939\u0940\u0928\u094b\u0902 \u092e\u0947\u0902 \u092e\u093e\u092a\u0928\u0947 \u092f\u094b\u0917\u094d\u092f \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0932\u093e\u092d\u094b\u0902 \u0915\u093e \u0905\u0928\u0941\u092d\u0935 \u0915\u093f\u092f\u093e\u0964.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0926\u0947\u0916\u0947 \u0917\u090f \u092a\u0930\u093f\u0923\u093e\u092e\u094b\u0902 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0936\u093e\u092e\u093f\u0932 \u0925\u0947:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>4-\u0938\u0940\u0922\u093c\u0940 \u091a\u0922\u093c\u0928\u0947 \u0915\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/strong>\n<ul class=\"wp-block-list\">\n<li>2.1 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930<\/li>\n\n\n\n<li><strong>\u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915-\u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 2.7 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908\u0964<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>10 \u092e\u0940\u091f\u0930 \u092a\u0948\u0926\u0932 \u091a\u0932\u0928\u093e\/\u0926\u094c\u0921\u093c\u0928\u093e\n<ul class=\"wp-block-list\">\n<li><strong>\u0909\u092a\u091a\u093e\u0930 \u0928 \u0915\u093f\u090f \u0917\u090f \u0938\u092e\u0942\u0939\u094b\u0902 \u092e\u0947\u0902 1.5 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 0.7 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930\u0964<\/strong><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u092b\u0930\u094d\u0936 \u0938\u0947 \u0909\u0920\u0928\u0947 \u0915\u093e \u0938\u092e\u092f\n<ul class=\"wp-block-list\">\n<li><strong>3.2 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930 \u092c\u0928\u093e\u092e 1.6 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937\u094b\u0902 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u0936\u093e\u092e\u093f\u0932 \u0925\u0947:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u094d\u0925\u093f\u0930 NSAA \u0938\u094d\u0915\u094b\u0930<\/strong><\/li>\n\n\n\n<li><strong>\u090a\u092a\u0930\u0940 \u0905\u0902\u0917\u094b\u0902 \u0915\u0947 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 (PUL) \u0938\u094d\u0915\u094b\u0930 \u092e\u0947\u0902 1.5 \u0905\u0902\u0915\u094b\u0902 \u0915\u093e \u0938\u0941\u0927\u093e\u0930<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092f\u0947 \u092a\u0930\u093f\u0923\u093e\u092e \u092c\u0924\u093e\u0924\u0947 \u0939\u0948\u0902 \u0915\u093f del-zota \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0917\u093f\u0930\u093e\u0935\u091f \u0915\u094b \u0927\u0940\u092e\u093e \u092f\u093e \u0938\u094d\u0925\u093f\u0930 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u094b \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u092e\u0947\u0902 \u090f\u0915 \u092a\u094d\u0930\u092e\u0941\u0916 \u0932\u0915\u094d\u0937\u094d\u092f \u0939\u0948\u0964.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"safety-and-tolerability\" class=\"wp-block-heading\">\u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0927\u094d\u092f\u092f\u0928\u094b\u0902 \u092e\u0947\u0902, del-zota \u0928\u0947 \u090f\u0915 \u0905\u0928\u0941\u0915\u0942\u0932 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u094b\u092b\u093c\u093e\u0907\u0932 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0915\u0940:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0918\u091f\u0928\u093e\u090f\u0902 \u0939\u0932\u094d\u0915\u0940 \u0938\u0947 \u092e\u0927\u094d\u092f\u092e \u0936\u094d\u0930\u0947\u0923\u0940 \u0915\u0940 \u0925\u0940\u0902\u0964<\/strong><\/li>\n\n\n\n<li>\u0915\u093f\u0938\u0940 \u092d\u0940 \u0905\u092a\u094d\u0930\u0924\u094d\u092f\u093e\u0936\u093f\u0924 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0938\u0902\u0915\u0947\u0924 \u0915\u0940 \u0938\u0942\u091a\u0928\u093e \u0928\u0939\u0940\u0902 \u092e\u093f\u0932\u0940\u0964<\/li>\n\n\n\n<li><strong>\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c \u0915\u0947 \u0938\u094d\u0924\u0930 \u092e\u0947\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0915\u092e\u0940 \u0926\u0947\u0916\u0940 \u0917\u0908\u0964<\/strong><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092f\u0947 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937 \u091a\u0930\u0923 3 SAFARI44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0928\u093f\u0930\u0902\u0924\u0930 \u091c\u093e\u0902\u091a \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"why-the-safari-44-trial-matters\" class=\"wp-block-heading\">SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u094d\u092f\u094b\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f del-zota \u091a\u0930\u0923 3 SAFARI44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u090f\u0915\u094d\u0938\u0949\u0928-44-\u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0928\u0908 \u0938\u091f\u0940\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u0947 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u093e\u0915\u094d\u0937\u094d\u092f \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964.<\/strong> \u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902: <a href=\"https:\/\/dmdwarrior.com\/hi\/upcoming-exon-44-skipping-therapies-for-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0906\u0917\u093e\u092e\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0926\u093f \u0938\u092b\u0932 \u0930\u0939\u093e, \u0924\u094b del-zota \u0928\u093f\u092e\u094d\u0928 \u0915\u093e\u0930\u094d\u092f \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092c\u0922\u093c\u093e\u090f\u0901<\/li>\n\n\n\n<li>\u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0940 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0937\u092e\u0924\u093e \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0915\u0930\u0947\u0902<\/li>\n\n\n\n<li>\u0930\u094b\u0917 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u092e\u0947\u0902 \u0926\u0947\u0930\u0940 \u0915\u0930\u0947\u0902<\/li>\n\n\n\n<li>\u0921\u0940\u090f\u092e\u0921\u0940 \u0938\u092e\u0941\u0926\u093e\u092f \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0935\u093f\u0915\u0932\u094d\u092a\u094b\u0902 \u0915\u093e \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u0915\u0930\u0947\u0902<\/li>\n<\/ul>\n\n\n\n<h2 id=\"in-which-countries-will-the-del-zota-phase-3-safari-44-clinical-trials-begin\" class=\"wp-block-heading\">Del-Zota \u092b\u0947\u091c 3 SAFARI44 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0915\u093f\u0928 \u0926\u0947\u0936\u094b\u0902 \u092e\u0947\u0902 \u0936\u0941\u0930\u0942 \u0939\u094b\u0902\u0917\u0947?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">del-zota \u0915\u0947 \u0924\u0940\u0938\u0930\u0947 \u091a\u0930\u0923 \u0915\u0947 SAFARI44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u094b \u090f\u0915 \u0935\u0948\u0936\u094d\u0935\u093f\u0915 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u091c\u093f\u0938\u0915\u093e \u0905\u0930\u094d\u0925 \u0939\u0948 \u0915\u093f \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u0940 \u092d\u0930\u094d\u0924\u0940 \u0915\u093f\u0938\u0940 \u090f\u0915 \u0926\u0947\u0936 \u0915\u0947 \u092c\u091c\u093e\u092f \u0915\u0908 \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u094b\u0902 \u092e\u0947\u0902 \u0939\u094b\u0917\u0940\u0964 \u0907\u0938 \u0905\u0927\u094d\u092f\u092f\u0928 \u092e\u0947\u0902 \u092f\u0942\u0930\u094b\u092a, \u090f\u0936\u093f\u092f\u093e \u0914\u0930 \u0905\u0928\u094d\u092f \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u094b\u0902 \u0915\u0947 \u0915\u0908 \u0926\u0947\u0936\u094b\u0902 \u0915\u0947 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u094b \u0936\u093e\u092e\u093f\u0932 \u0915\u093f\u090f \u091c\u093e\u0928\u0947 \u0915\u0940 \u0909\u092e\u094d\u092e\u0940\u0926 \u0939\u0948\u0964 Avidity Biosciences \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 \u0909\u0928 \u0926\u0947\u0936\u094b\u0902 \u0915\u0940 \u0918\u094b\u0937\u0923\u093e \u0915\u0940 \u091c\u093e\u090f\u0917\u0940 \u091c\u0939\u093e\u0902 SAFARI44 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0906\u092f\u094b\u091c\u093f\u0924 \u0915\u093f\u092f\u093e \u091c\u093e\u090f\u0917\u093e\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0907\u0938 \u092a\u0947\u091c \u0915\u094b \u092b\u093c\u0949\u0932\u094b \u0915\u0930\u0947\u0902<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/hi\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u0915\u0947 \u0932\u093f\u090f \u0938\u092d\u0940 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The del-zota phase 3 SAFARI44 clinical trial for Duchenne muscular dystrophy represents a major step toward developing targeted treatments for patients with exon-44\u2013amenable genetic mutations in Duchenne Muscular Dystrophy. Learn More: Mutations and Deletions Amenable to Exon 44 Skipping Therapies Presented at the Muscular Dystrophy Association Clinical &amp; Scientific Conference, the SAFARI44 study evaluates the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":6751,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[126,137,298,141,127,246,77,178],"class_list":["post-6747","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-avidity-biosciences","tag-clinical-trial","tag-del-zota","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-exon-skipping","tag-exon-skipping-therapies"],"subtitle":"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u092e\u0947\u0902 \u090f\u0915 \u0928\u092f\u093e \u092e\u0940\u0932 \u0915\u093e \u092a\u0924\u094d\u0925\u0930 \u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0939\u094b \u0930\u0939\u093e \u0939\u0948, \u0915\u094d\u092f\u094b\u0902\u0915\u093f \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f del-zota \u091a\u0930\u0923 3 SAFARI44 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u091a\u0932 \u0930\u0939\u093e \u0939\u0948\u0964 \u092f\u0939 \u0905\u0927\u094d\u092f\u092f\u0928 \u090f\u0915 \u0932\u0915\u094d\u0937\u093f\u0924 \u090f\u0915\u094d\u0938\u0949\u0928-44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0947 \u0907\u0938 \u0926\u0941\u0930\u094d\u0932\u092d \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u0930\u094b\u0917 \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u094b \u092c\u0939\u093e\u0932 \u0915\u0930\u0928\u0947 \u0914\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0915\u093e\u0930\u094d\u092f \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948\u0964.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/6747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=6747"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/6747\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/6751"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=6747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=6747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=6747"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}