{"id":5236,"date":"2025-11-26T10:09:01","date_gmt":"2025-11-26T07:09:01","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5236"},"modified":"2025-11-26T10:09:50","modified_gmt":"2025-11-26T07:09:50","slug":"researchers-develop-optimized-smad7-gene-therapy-to-target-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/researchers-develop-optimized-smad7-gene-therapy-to-target-duchenne-muscular-dystrophy\/","title":{"rendered":"\u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u0928\u0947 \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u094b \u0932\u0915\u094d\u0937\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0915\u0942\u0932\u093f\u0924 Smad7 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u0940 \u0939\u0948"},"content":{"rendered":"<p class=\"wp-block-paragraph\">25 \u0928\u0935\u0902\u092c\u0930, 2025 \u0915\u094b, \u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u092c\u0941\u090f\u0932 \u0921\u0940. \u0930\u0949\u091c\u0930\u094d\u0938 \u0914\u0930 \u0915\u094d\u0930\u093f\u0938\u094d\u091f\u094b\u092b\u0930 \u0921\u092c\u094d\u0932\u094d\u092f\u0942. \u0935\u093e\u0930\u094d\u0921 \u0928\u0947 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u092e\u0947\u0902 \u090f\u0915 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0905\u0927\u094d\u092f\u092f\u0928 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0915\u093f\u092f\u093e, \u091c\u093f\u0938\u092e\u0947\u0902 \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (\u0921\u0940\u090f\u092e\u0921\u0940) \u0915\u0947 \u0907\u0932\u093e\u091c \u0915\u0947 \u0909\u0926\u094d\u0926\u0947\u0936\u094d\u092f \u0938\u0947 \u090f\u0915 \u0915\u094b\u0921\u094b\u0928-\u0905\u0928\u0941\u0915\u0942\u0932\u093f\u0924 \u092e\u093e\u0928\u0935 \u0938\u094d\u092e\u0948\u09217 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u0905\u0928\u093e\u0935\u0930\u0923 \u0915\u093f\u092f\u093e \u0917\u092f\u093e\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0939 \u0917\u0902\u092d\u0940\u0930 \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u0935\u093f\u0915\u093e\u0930 \u092e\u0941\u0916\u094d\u092f\u0924\u0903 \u092f\u0941\u0935\u093e \u0932\u0921\u093c\u0915\u094b\u0902 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e\u0938\u094d\u0935\u0930\u0942\u092a \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u093e \u0915\u094d\u0930\u092e\u093f\u0915 \u0915\u094d\u0937\u0930\u0923, \u0917\u0924\u093f\u0936\u0940\u0932\u0924\u093e \u092e\u0947\u0902 \u0915\u092e\u0940 \u0914\u0930 \u0926\u0941\u0916\u0926 \u0930\u0942\u092a \u0938\u0947, \u0938\u092e\u092f \u0938\u0947 \u092a\u0939\u0932\u0947 \u092e\u0943\u0924\u094d\u092f\u0941 \u0939\u094b \u091c\u093e\u0924\u0940 \u0939\u0948\u0964 \u0915\u0949\u0930\u094d\u091f\u093f\u0915\u094b\u0938\u094d\u091f\u0947\u0930\u0949\u0907\u0921\u094d\u0938 \u091c\u0948\u0938\u0947 \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u0909\u092a\u091a\u093e\u0930 \u0935\u093f\u0915\u0932\u094d\u092a \u0915\u0947\u0935\u0932 \u0938\u0940\u092e\u093f\u0924 \u0930\u093e\u0939\u0924 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902 \u0914\u0930 \u0930\u094b\u0917 \u0915\u0940 \u0928\u093f\u0930\u0902\u0924\u0930 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u094b \u0928\u0939\u0940\u0902 \u0930\u094b\u0915 \u092a\u093e\u0924\u0947\u0964 \u092a\u0930\u093f\u0923\u093e\u092e\u0938\u094d\u0935\u0930\u0942\u092a, \u0921\u0940\u090f\u092e\u0921\u0940 \u0938\u092e\u0941\u0926\u093e\u092f \u092e\u0947\u0902 \u0928\u090f \u0909\u092a\u091a\u093e\u0930\u094b\u0902 \u0915\u0940 \u0924\u0924\u094d\u0915\u093e\u0932 \u0914\u0930 \u0939\u093e\u0930\u094d\u0926\u093f\u0915 \u092e\u093e\u0902\u0917 \u0939\u0948\u0964.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#smad-7-gene-therapy\">\u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0932\u093f\u090f Smad7 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/li><li><a href=\"#key-points\">Smad7 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u092e\u0941\u0916\u094d\u092f \u092c\u093f\u0902\u0926\u0941<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"smad-7-gene-therapy\">\u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0932\u093f\u090f Smad7 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0939 \u0905\u092d\u093f\u0928\u0935 \u0926\u0943\u0937\u094d\u091f\u093f\u0915\u094b\u0923 Smad7 \u091c\u0940\u0928 \u092a\u0930 \u0915\u0947\u0902\u0926\u094d\u0930\u093f\u0924 \u0939\u0948, \u091c\u094b \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u092e\u0930\u092e\u094d\u092e\u0924 \u0915\u0947 \u092a\u0940\u091b\u0947 \u0915\u0940 \u0915\u094b\u0936\u093f\u0915\u0940\u092f \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e\u0913\u0902 \u0915\u0947 \u092a\u094d\u0930\u092c\u0902\u0927\u0928 \u0915\u0947 \u0932\u093f\u090f \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948\u0964 Smad7 \u0915\u0947 \u0915\u094b\u0921\u0949\u0928 \u0905\u0928\u0941\u0915\u094d\u0930\u092e \u0915\u094b \u092a\u0930\u093f\u0937\u094d\u0915\u0943\u0924 \u0915\u0930\u0915\u0947, \u091f\u0940\u092e \u0928\u0947 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u090a\u0924\u0915\u094b\u0902 \u092e\u0947\u0902 \u0907\u0938\u0915\u0940 \u092a\u094d\u0930\u092d\u093e\u0935\u0936\u0940\u0932\u0924\u093e \u0915\u094b \u092c\u0922\u093c\u093e\u0928\u0947 \u0915\u093e \u092a\u094d\u0930\u092f\u093e\u0938 \u0915\u093f\u092f\u093e\u0964 \u0939\u093e\u0932\u093e\u0901\u0915\u093f \u092f\u0947 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937 DMD \u0915\u0940 \u091a\u0941\u0928\u094c\u0924\u093f\u092f\u094b\u0902 \u0938\u0947 \u0928\u093f\u092a\u091f\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0928\u0908 \u0930\u0923\u0928\u0940\u0924\u093f\u092f\u094b\u0902 \u0915\u093e \u092e\u093e\u0930\u094d\u0917 \u092a\u094d\u0930\u0936\u0938\u094d\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u0932\u0947\u0915\u093f\u0928 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0907\u0938\u0915\u0947 \u0909\u092a\u092f\u094b\u0917 \u0938\u0947 \u092a\u0939\u0932\u0947 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0915\u0940 \u092a\u094d\u0930\u092d\u093e\u0935\u0915\u093e\u0930\u093f\u0924\u093e \u0914\u0930 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0915\u093e \u0917\u0939\u0928 \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u0936\u094b\u0927 \u0906\u0935\u0936\u094d\u092f\u0915 \u0939\u094b\u0917\u093e\u0964 &gt;&gt;&gt; <strong>\u0914\u0930 \u092a\u0922\u093c\u0947\u0902<\/strong>: <a href=\"https:\/\/www.nature.com\/articles\/s41434-025-00583-0\" target=\"_blank\" rel=\"noreferrer noopener\">\u0928\u0947\u091a\u0930.\u0915\u0949\u092e<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"key-points\">Smad7 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u092e\u0941\u0916\u094d\u092f \u092c\u093f\u0902\u0926\u0941<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0939\u093e\u0932\u093f\u092f\u093e \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937\u094b\u0902 \u0928\u0947 \u092e\u0942\u0937\u0915 \u092e\u0949\u0921\u0932\u094b\u0902 \u092e\u0947\u0902 \u092a\u094d\u0930\u092d\u093e\u0935\u0936\u093e\u0932\u0940 \u092a\u0930\u093f\u0923\u093e\u092e \u0909\u091c\u093e\u0917\u0930 \u0915\u093f\u090f \u0939\u0948\u0902\u0964. <strong>\u0905\u0928\u0941\u0915\u0942\u0932\u093f\u0924 Smad7 \u091c\u0940\u0928 \u0938\u0947 \u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u091a\u0942\u0939\u094b\u0902 \u092e\u0947\u0902 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0926\u094d\u0930\u0935\u094d\u092f\u092e\u093e\u0928 \u092e\u0947\u0902 \u0909\u0932\u094d\u0932\u0947\u0916\u0928\u0940\u092f \u0935\u0943\u0926\u094d\u0927\u093f \u0926\u0947\u0916\u0940 \u0917\u0908, \u091c\u093f\u0938\u0915\u093e \u092a\u094d\u0930\u092e\u093e\u0923 \u0936\u0915\u094d\u0924\u093f \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0938\u0947 \u092e\u093f\u0932\u0924\u093e \u0939\u0948\u0964.<\/strong> \u090a\u0924\u0915\u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u0938\u0947 \u092b\u093e\u0907\u092c\u094d\u0930\u094b\u0938\u093f\u0938 \u092e\u0947\u0902 \u0915\u092e\u0940 \u0914\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u0938\u0902\u0930\u091a\u0928\u093e \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0926\u0947\u0916\u093e \u0917\u092f\u093e, \u091c\u093f\u0938\u0938\u0947 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u092b\u093e\u0907\u092c\u0930 \u0915\u0940 \u092e\u093e\u0924\u094d\u0930\u093e \u0914\u0930 \u0917\u0941\u0923\u0935\u0924\u094d\u0924\u093e \u0926\u094b\u0928\u094b\u0902 \u092e\u0947\u0902 \u0938\u0941\u0927\u093e\u0930 \u0939\u0941\u0906\u0964 \u0905\u0927\u094d\u092f\u092f\u0928 \u0907\u0938 \u092c\u093e\u0924 \u092a\u0930 \u091c\u093c\u094b\u0930 \u0926\u0947\u0924\u093e \u0939\u0948 \u0915\u093f \u092f\u0947 \u092a\u094d\u0930\u0917\u0924\u093f \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940\u092f \u0926\u0941\u0930\u094d\u0935\u093f\u0915\u093e\u0938 \u0915\u0947 \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u0909\u092a\u091a\u093e\u0930 \u092e\u0947\u0902 \u090f\u0915 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u0915\u093e\u0930\u0940 \u092c\u0926\u0932\u093e\u0935 \u0915\u093e \u0938\u0902\u0915\u0947\u0924 \u0926\u0947\u0924\u0940 \u0939\u0948, \u091c\u094b \u0915\u0947\u0935\u0932 \u0938\u0902\u0916\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0938\u0941\u0927\u093e\u0930\u094b\u0902 \u0938\u0947 \u0915\u0939\u0940\u0902 \u0906\u0917\u0947 \u0924\u0915 \u092b\u0948\u0932\u0940 \u0939\u0941\u0908 \u0939\u0948\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0907\u0938 \u092a\u0947\u091c \u0915\u094b \u092b\u093c\u0949\u0932\u094b \u0915\u0930\u0947\u0902<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/hi\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u0915\u0947 \u0932\u093f\u090f \u0938\u092d\u0940 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>On November 25, 2025, researchers Buel D. Rodgers and Christopher W. Ward published a groundbreaking study in Gene Therapy that unveiled a codon-optimized human Smad7 gene therapy aimed at treating Duchenne muscular dystrophy (DMD). This serious genetic disorder primarily affects young boys, resulting in progressive muscle degeneration, a loss of mobility, and tragically, early death. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5240,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[61,457,458],"class_list":["post-5236","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-gene-therapy","tag-smad7","tag-smad7-gene-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/5236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=5236"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/5236\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/5240"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=5236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=5236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=5236"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}