{"id":4953,"date":"2025-10-30T11:58:41","date_gmt":"2025-10-30T08:58:41","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4953"},"modified":"2025-10-30T11:58:42","modified_gmt":"2025-10-30T08:58:42","slug":"hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy\/","title":{"rendered":"\u0939\u0902\u0938\u093e \u0907\u092e\u094d\u0932\u0940\u092b\u093f\u0921\u0947\u091c \u090f\u0902\u091f\u0940-\u090f\u090f\u0935\u0940 \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940 \u0915\u094b \u0915\u092e \u0915\u0930\u0924\u093e \u0939\u0948 \u0914\u0930 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u0915\u0940 \u0905\u0928\u0941\u092e\u0924\u093f \u0926\u0947\u0924\u093e \u0939\u0948"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (\u0921\u0940\u090f\u092e\u0921\u0940) \u092e\u0947\u0902 \u090f\u0938\u0906\u0930\u092a\u0940-9001-104: \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0938\u0930\u0947\u092a\u094d\u091f\u093e \u0915\u0947 \u090f\u0932\u0947\u0935\u093f\u0921\u0940\u0938 \u0915\u0947 \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u0938\u0947 \u092a\u0939\u0932\u0947 \u0907\u092e\u0932\u0940\u092b\u093f\u0921\u0947\u091c \u0915\u0947 \u0938\u093e\u0925 \u0907\u0932\u093e\u091c \u0915\u093f\u090f \u0917\u090f \u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0924\u0940\u0928 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0936\u0940\u0930\u094d\u0937 \u092a\u0930\u093f\u0923\u093e\u092e \u092c\u0924\u093e\u090f \u0917\u090f\u0964.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0926\u094b \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u090f\u0915 \u0938\u0930\u0947\u092a\u094d\u091f\u093e \u0926\u094d\u0935\u093e\u0930\u093e \u092a\u094d\u0930\u093e\u092f\u094b\u091c\u093f\u0924 \u0914\u0930 \u0926\u0942\u0938\u0930\u093e Genethon \u0926\u094d\u0935\u093e\u0930\u093e \u092a\u094d\u0930\u093e\u092f\u094b\u091c\u093f\u0924, \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u0915\u0940 \u0905\u0928\u0941\u092e\u0924\u093f \u0926\u0947\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u090f\u0902\u091f\u0940-\u090f\u090f\u0935\u0940 \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940 \u0915\u094b \u0915\u093e\u092b\u0940 \u0939\u0926 \u0924\u0915 \u0915\u092e \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0907\u092e\u0932\u0940\u092b\u093f\u0921\u0947\u091c \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0909\u091a\u094d\u091a \u090f\u0902\u091f\u0940-\u090f\u090f\u0935\u0940 \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940 \u0905\u092c \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u092e\u0947\u0902 \u092c\u093e\u0927\u093e \u0928\u0939\u0940\u0902 \u092c\u0928 \u0938\u0915\u0924\u0940 \u0939\u0948\u0902<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0907\u092e\u094d\u0932\u093f\u092b\u093f\u0921\u0947\u091c\u093c \u0915\u0940 \u090f\u0915 \u0916\u0941\u0930\u093e\u0915 \u0915\u0947 \u092c\u093e\u0926, \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 IgG \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940\u091c\u093c \u092e\u0947\u0902 \u0924\u0947\u091c\u093c\u0940 \u0938\u0947 \u0915\u092e\u0940 \u0926\u0947\u0916\u0940 \u0917\u0908, \u091c\u094b \u0915\u093f \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 \u226595% \u0915\u092e \u0925\u0940\u0964 \u0907\u0938\u0915\u0947 \u0905\u0932\u093e\u0935\u093e, \u092a\u0939\u0932\u0947 \u0938\u0947 \u092e\u094c\u091c\u0942\u0926 \u090f\u0902\u091f\u0940-AAV \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940\u091c\u093c \u0915\u093e \u0938\u094d\u0924\u0930 1:400 \u0938\u0947 \u0915\u092e \u0939\u094b \u0917\u092f\u093e, \u091c\u093f\u0938\u0938\u0947 ELEVIDYS \u0938\u0947 \u0909\u092a\u091a\u093e\u0930 \u0938\u0902\u092d\u0935 \u0939\u094b \u0917\u092f\u093e\u0964 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0915\u094b\u0908 \u0928\u092f\u093e \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0938\u0902\u0915\u0947\u0924 \u0928\u0939\u0940\u0902 \u0926\u0947\u0916\u093e \u0917\u092f\u093e\u0964 \u092f\u0947 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0906\u0901\u0915\u0921\u093c\u0947 \u0907\u092e\u094d\u0932\u093f\u092b\u093f\u0921\u0947\u091c\u093c \u0915\u0940 \u090f\u0902\u091f\u0940-AAV \u090f\u0902\u091f\u0940\u092c\u0949\u0921\u0940\u091c\u093c \u0915\u094b \u0915\u093e\u092b\u093c\u0940 \u0939\u0926 \u0924\u0915 \u0915\u092e \u0915\u0930\u0928\u0947 \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0915\u093e \u0938\u092e\u0930\u094d\u0925\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902 \u091c\u093f\u0938\u0938\u0947 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0938\u0902\u092d\u0935 \u0939\u094b \u0938\u0915\u0947\u0964. <a href=\"https:\/\/dmdwarrior.com\/hi\/high-anti-aav-antibodies-may-not-prevent-elevidys-administration\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0907\u092e\u094d\u0932\u093f\u092b\u093e\u0907\u0921\u0947\u091c\u093c \u0915\u0947 \u092c\u093e\u0930\u0947 \u092e\u0947\u0902 \u0914\u0930 \u092a\u0922\u093c\u0947\u0902<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SRP-9001-104 in Duchenne muscular dystrophy (DMD): Topline results were reported for three patients with DMD treated with imlifidase prior to administration of Sarepta&#8217;s ELEVIDYS in the trial. Two gene therapy trials, one sponsored by Sarepta and the other sponsored by Genethon, support the ability of imlifidase to substantially reduce anti-AAV antibodies to allow administration of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4954,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[368,448,61,401],"class_list":["post-4953","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aav-based-gene-therapy","tag-anti-aav","tag-gene-therapy","tag-hansa-biopharma"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=4953"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/4954"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=4953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=4953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=4953"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}