{"id":4576,"date":"2025-09-25T16:23:32","date_gmt":"2025-09-25T13:23:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4576"},"modified":"2025-09-25T16:23:33","modified_gmt":"2025-09-25T13:23:33","slug":"spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012\/","title":{"rendered":"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0936\u0941\u0930\u0942"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Shanghai Siponuoyin \u092c\u093e\u092f\u094b\u091f\u0947\u0915\u094d\u0928\u094b\u0932\u0949\u091c\u0940 \u0926\u094d\u0935\u093e\u0930\u093e \u0935\u093f\u0915\u0938\u093f\u0924 \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (DMD) \u0915\u0947 \u0932\u093f\u090f SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1 \u0905\u0927\u094d\u092f\u092f\u0928 (NCT07188012) \u092a\u094d\u0930\u0936\u093e\u0938\u0928 \u0915\u0947 \u092c\u093e\u0926 \u0915\u0902\u0915\u093e\u0932 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u0940 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0905\u092d\u093f\u0935\u094d\u092f\u0915\u094d\u0924\u093f \u0915\u093e \u090f\u0915 \u092a\u093e\u092f\u0932\u091f \u0905\u0927\u094d\u092f\u092f\u0928 \u0939\u0948\u0964<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#what-is-spot-m-rna-03-gene-therapy\">SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u094d\u092f\u093e \u0939\u0948?<\/a><\/li><li><a href=\"#spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\">SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1 \u2013 NCT07188012<\/a><\/li><li><a href=\"#how-to-participate-in-the-sgt-003-clinical-trial\">SPOT-mRNA03 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0915\u0948\u0938\u0947 \u092d\u093e\u0917 \u0932\u0947\u0902<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-spot-m-rna-03-gene-therapy\"><strong>SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u094d\u092f\u093e \u0939\u0948?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SPOT-mRNA03 \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (\u0921\u0940\u090f\u092e\u0921\u0940) \u0915\u0947 \u0932\u093f\u090f \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0909\u0924\u094d\u092a\u093e\u0926 \u0939\u0948\u0964<\/strong> \u0921\u0940\u090f\u092e\u0921\u0940 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u094b \u0926\u093f\u090f \u091c\u093e\u0928\u0947 \u0915\u0947 \u092c\u093e\u0926, \u0908\u0935\u0940\u090f\u0938 \u0915\u0940 \u091d\u093f\u0932\u094d\u0932\u0940 \u092a\u0930 \u0906\u0923\u0935\u093f\u0915 \u0932\u0915\u094d\u0937\u094d\u092f\u0940\u0915\u0930\u0923 \u092a\u0947\u092a\u094d\u091f\u093e\u0907\u0921 SPOT-mRNA03 \u0915\u094b \u0930\u094b\u0917\u0940 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u092e\u0947\u0902 \u0928\u093f\u0930\u094d\u0926\u0947\u0936\u093f\u0924 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0905\u0902\u0924\u0903\u0915\u094b\u0936\u093f\u0915\u0940\u092f \u0930\u093e\u0907\u092c\u094b\u0938\u094b\u092e \u0914\u0930 \u0905\u092e\u0940\u0928\u094b \u090f\u0938\u093f\u0921 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0915\u0947 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u0940 \u0915\u092e\u0940 \u0935\u093e\u0932\u0947 \u0930\u093f\u0938\u0947\u092a\u094d\u091f\u0930 \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u0926\u094d\u0935\u093e\u0930\u093e \u0905\u0902\u0924\u0930\u094d\u091c\u093e\u0924 \u092a\u0942\u0930\u094d\u0923-\u0932\u0902\u092c\u093e\u0908 \u0935\u093e\u0932\u0947 \u0905\u0915\u094d\u0937\u0941\u0923\u094d\u0923 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u093e \u0905\u0928\u0941\u0935\u093e\u0926 \u0914\u0930 \u0938\u094d\u0930\u093e\u0935 \u0938\u0902\u092d\u0935 \u0939\u094b \u091c\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\"><strong>SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1 \u2013 NCT07188012<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0939 \u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u094b \u0905\u0902\u0924\u0903\u0936\u093f\u0930\u093e \u0930\u0942\u092a \u0938\u0947 \u0926\u093f\u090f \u091c\u093e\u0928\u0947 \u0935\u093e\u0932\u0947 SPOT-mRNA03 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0915\u0947 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u090f\u0915 \u090f\u0915\u0932-\u092d\u0941\u091c\u093e, \u0913\u092a\u0928-\u0932\u0947\u092c\u0932, FIH, \u090f\u0915\u0932-\u0915\u0947\u0902\u0926\u094d\u0930 \u0905\u0928\u094d\u0935\u0947\u0937\u0923\u093e\u0924\u094d\u092e\u0915 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0939\u0948\u0964 \u092a\u0942\u0930\u094d\u0923-\u0932\u0902\u092c\u093e\u0908 \u0935\u093e\u0932\u093e \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 mRNA, SPOT-mRNA03 \u0928\u093e\u092e\u0915 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940-\u0932\u0915\u094d\u0937\u093f\u0924 \u092c\u093e\u0939\u094d\u092f\u0915\u094b\u0936\u093f\u0915\u0940\u092f \u092a\u0941\u091f\u093f\u0915\u093e\u0913\u0902 (EVs) \u092e\u0947\u0902 \u0938\u092e\u093e\u0939\u093f\u0924 \u0939\u094b\u0924\u093e \u0939\u0948\u0964 EVs \u091d\u093f\u0932\u094d\u0932\u0940 \u092a\u0930 \u0906\u0923\u0935\u093f\u0915 \u0932\u0915\u094d\u0937\u094d\u092f\u0940\u0915\u0930\u0923 \u092a\u0947\u092a\u094d\u091f\u093e\u0907\u0921\u094d\u0938 SPOT-mRNA03 \u0915\u094b \u0909\u0938\u0915\u0940 \u0932\u0915\u094d\u0937\u094d\u092f\u0940\u0915\u0930\u0923 \u0915\u094d\u0937\u092e\u0924\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u091c\u093f\u0938\u0938\u0947 \u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0932\u093f\u090f \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0909\u0924\u094d\u092a\u093e\u0926 \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 mRNA \u0915\u093e \u0935\u093f\u0924\u0930\u0923 \u0938\u0902\u092d\u0935 \u0939\u094b \u092a\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0905\u0927\u094d\u092f\u092f\u0928 \u092a\u094d\u0930\u093e\u0930\u0902\u092d (\u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924)<\/strong>: 2025-08-06<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092a\u094d\u0930\u093e\u0925\u092e\u093f\u0915 \u092a\u0942\u0930\u094d\u0923\u0924\u093e (\u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0905\u0927\u094d\u092f\u092f\u0928 \u092a\u0942\u0930\u094d\u0923\u0924\u093e (\u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u0940 \u0938\u0902\u0916\u094d\u092f\u093e (\u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924)<\/strong>: 6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u091f\u093e\u0907\u092a \u0915\u0930\u0928\u093e \u0938\u0940\u0916\u094b<\/strong>: \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u091c\u0917\u0939<\/strong>: <a href=\"https:\/\/maps.app.goo.gl\/Z2CyEqLydJ4Kxh9aA\" target=\"_blank\" rel=\"noreferrer noopener\">\u0936\u0902\u0918\u093e\u0908 \u091a\u093f\u0932\u094d\u0921\u094d\u0930\u0928\u094d\u0938 \u092e\u0947\u0921\u093f\u0915\u0932 \u0938\u0947\u0902\u091f\u0930<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0947 \u0932\u093f\u090f \u092f\u094b\u0917\u094d\u092f \u0906\u092f\u0941<\/strong>: 2 \u0935\u0930\u094d\u0937 \u0938\u0947 6 \u0935\u0930\u094d\u0937 (\u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u0935\u093e\u0932\u0947 \u092a\u0941\u0930\u0941\u0937)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u092a\u094d\u0930\u092e\u0941\u0916 \u0938\u092e\u093e\u0935\u0947\u0936\u0928 \u0914\u0930 \u092c\u0939\u093f\u0937\u094d\u0915\u0930\u0923 \u092e\u093e\u0928\u0926\u0902\u0921. \u2013 <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07188012\" target=\"_blank\" rel=\"noreferrer noopener\">\u090f\u0928\u0938\u0940\u091f\u094007188012<\/a> \u2013<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-to-participate-in-the-sgt-003-clinical-trial\"><strong>SPOT-mRNA03 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0915\u0948\u0938\u0947 \u092d\u093e\u0917 \u0932\u0947\u0902<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">SPOT-mRNA03 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u091a\u0930\u0923 1 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u092d\u093e\u0917 \u0932\u0947\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f, \u0906\u092a \u0928\u0940\u091a\u0947 \u0926\u0940 \u0917\u0908 \u0938\u0902\u092a\u0930\u094d\u0915 \u091c\u093e\u0928\u0915\u093e\u0930\u0940 \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930 \u0938\u0915\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0928\u093e\u092e<\/strong>: \u0935\u093f\u0902\u0938\u094d\u091f\u0928 \u091f\u093e\u0909\u0928<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092b\u093c\u094b\u0928 \u0928\u0902\u092c\u0930<\/strong>: 212-920-5501<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0908\u092e\u0947\u0932<\/strong>: Winston.town@spotbiosystems.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The early phase 1 study (NCT07188012) of SPOT-mRNA03 gene therapy for Duchenne Muscular Dystrophy (DMD) developed by Shanghai Siponuoyin Biotechnology is a pilot study of the safety and expression of dystrophin in skeletal muscles after administration. What is SPOT-mRNA03 Gene Therapy SPOT-mRNA03 is the gene therapy product for Duchenne Muscular Dystrophy (DMD). Following administration to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4580,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[123,137,242,359,61,424,423,425],"class_list":["post-4576","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-china","tag-clinical-trial","tag-clinical-trials","tag-full-length-dystrophin","tag-gene-therapy","tag-shanghai-siponuoyin","tag-spot-mrna03","tag-spot-mrna03-gene-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=4576"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/4580"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=4576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=4576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=4576"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}