{"id":4518,"date":"2025-09-19T16:43:25","date_gmt":"2025-09-19T13:43:25","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4518"},"modified":"2025-09-19T16:43:27","modified_gmt":"2025-09-19T13:43:27","slug":"mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd\/","title":{"rendered":"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (\u0921\u0940\u090f\u092e\u0921\u0940) \u090f\u0915 \u0917\u0902\u092d\u0940\u0930 \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u0935\u093f\u0915\u093e\u0930 \u0939\u0948 \u091c\u094b \u0921\u0940\u090f\u092e\u0921\u0940 \u091c\u0940\u0928 \u092e\u0947\u0902 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0915\u0947 \u0915\u093e\u0930\u0923 \u0939\u094b\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0915\u0947 \u0915\u093e\u0930\u0923 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0940 \u092e\u091c\u092c\u0942\u0924\u0940 \u0914\u0930 \u0938\u094d\u0925\u093f\u0930\u0924\u093e \u0915\u0947 \u0932\u093f\u090f \u0906\u0935\u0936\u094d\u092f\u0915 \u092a\u094d\u0930\u094b\u091f\u0940\u0928, \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928, \u0905\u0928\u0941\u092a\u0938\u094d\u0925\u093f\u0924 \u092f\u093e \u0932\u0917\u092d\u0917 \u0905\u0928\u0941\u092a\u0938\u094d\u0925\u093f\u0924 \u0939\u094b \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0939\u093e\u0932\u093e\u0901\u0915\u093f, \u0915\u0941\u091b \u0935\u094d\u092f\u0915\u094d\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f, \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u091c\u0948\u0938\u0947 \u0906\u0936\u093e\u091c\u0928\u0915 \u0909\u092a\u091a\u093e\u0930 \u0906\u0936\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u2014\u0916\u093e\u0938\u0915\u0930 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917, \u091c\u094b \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u092e\u0947\u0902 \u0938\u092c\u0938\u0947 \u0905\u0927\u093f\u0915 \u0932\u0915\u094d\u0937\u093f\u0924 \u090f\u0915\u094d\u0938\u0949\u0928 \u0939\u0948\u0964 <strong>\u0907\u0938 \u0932\u0947\u0916 \u092e\u0947\u0902, \u0939\u092e \u092f\u0939 \u092a\u0924\u093e \u0932\u0917\u093e\u090f\u0902\u0917\u0947 \u0915\u093f \u0915\u094c\u0928 \u0938\u0947 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0939\u0948\u0902 \u0914\u0930 \u092f\u0939 \u0915\u0948\u0938\u0947 \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u093f\u0924 \u0915\u093f\u092f\u093e \u091c\u093e\u090f \u0915\u093f \u0915\u093f\u0938\u0940 \u0930\u094b\u0917\u0940 \u0915\u094b \u0907\u0938 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0938\u0947 \u0932\u093e\u092d \u0939\u094b \u0938\u0915\u0924\u093e \u0939\u0948 \u092f\u093e \u0928\u0939\u0940\u0902\u0964<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#what-is-exon-51-skipping-therapy\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u094d\u092f\u093e \u0939\u0948?<\/a><ul><li><a href=\"#approved-exon-51-skipping-therapy\">\u0938\u094d\u0935\u0940\u0915\u0943\u0924 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/li><\/ul><\/li><li><a href=\"#why-is-exon-51-important-in-dmd\">\u0921\u0940\u090f\u092e\u0921\u0940 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094d\u092f\u094b\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948?<\/a><\/li><li><a href=\"#deletions-amenable-for-exon-44-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0935\u093f\u0932\u094b\u092a\u0928<\/a><ul><li><a href=\"#common-deletions-amenable-to-exon-51-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u092f\u094b\u0917\u094d\u092f \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0935\u093f\u0932\u094b\u092a\u0928<\/a><\/li><\/ul><\/li><li><a href=\"#mutations-amenable-to-exon-44-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928<\/a><\/li><li><a href=\"#potential-benefits-of-exon-44-skipping-for-dmd-patients\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940: \u0915\u094d\u092f\u093e \u0905\u092a\u0947\u0915\u094d\u0937\u093e \u0915\u0930\u0947\u0902<\/a><\/li><li><a href=\"#summary-is-your-child-a-candidate-for-exon-51-skipping\">\u0938\u093e\u0930\u093e\u0902\u0936: \u0915\u094d\u092f\u093e \u0906\u092a\u0915\u093e \u092c\u091a\u094d\u091a\u093e \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u092e\u094d\u092e\u0940\u0926\u0935\u093e\u0930 \u0939\u0948?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-exon-51-skipping-therapy\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u094d\u092f\u093e \u0939\u0948?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u090f\u0915 \u0938\u091f\u0940\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u092a\u0926\u094d\u0927\u0924\u093f \u0939\u0948 \u091c\u094b \u0921\u0940\u090f\u092e\u0921\u0940 \u091c\u0940\u0928 \u0915\u0947 \u092e\u0948\u0938\u0947\u0902\u091c\u0930 \u0906\u0930\u090f\u0928\u090f (\u090f\u092e\u0906\u0930\u090f\u0928\u090f) \u0915\u0947 \u092a\u094d\u0930\u0938\u0902\u0938\u094d\u0915\u0930\u0923 \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b &quot;\u0938\u094d\u0915\u093f\u092a&quot; \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0938\u093f\u0902\u0925\u0947\u091f\u093f\u0915 \u0905\u0923\u0941\u0913\u0902 (\u091c\u093f\u0928\u094d\u0939\u0947\u0902 \u090f\u0902\u091f\u0940\u0938\u0947\u0902\u0938 \u0911\u0932\u093f\u0917\u094b\u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u094b\u091f\u093e\u0907\u0921\u094d\u0938 \u0915\u0939\u093e \u091c\u093e\u0924\u093e \u0939\u0948) \u0915\u093e \u0909\u092a\u092f\u094b\u0917 \u0915\u0930\u0924\u0940 \u0939\u0948\u0964 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u0938\u094d\u0915\u093f\u092a \u0915\u0930\u0915\u0947, \u0909\u092a\u091a\u093e\u0930 \u091c\u0940\u0928 \u0915\u0947 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u0915\u094b \u092a\u0941\u0928\u0930\u094d\u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0936\u0930\u0940\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u093e \u090f\u0915 \u091b\u094b\u091f\u093e \u0932\u0947\u0915\u093f\u0928 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0938\u0902\u0938\u094d\u0915\u0930\u0923 \u0909\u0924\u094d\u092a\u0928\u094d\u0928 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"approved-exon-51-skipping-therapy\">\u0938\u094d\u0935\u0940\u0915\u0943\u0924 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>1\u091f\u0940\u092a\u094026\u091f\u0940 (1\u091f\u0940\u092a\u094044\u091f\u0940 51)<\/strong> - \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u0935\u093e\u0932\u0947 \u0921\u0940\u090f\u092e\u0921\u0940 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0907\u0932\u093e\u091c \u0915\u0947 \u0932\u093f\u090f \u092f\u0942\u090f\u0938 1\u091f\u0940\u092a\u0940123\u091f\u0940 \u0926\u094d\u0935\u093e\u0930\u093e \u0905\u0928\u0941\u092e\u094b\u0926\u093f\u0924\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-is-exon-51-important-in-dmd\">\u0921\u0940\u090f\u092e\u0921\u0940 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094d\u092f\u094b\u0902 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0921\u0940\u090f\u092e\u0921\u0940 \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0932\u0917\u092d\u0917 13% \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0910\u0938\u0947 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902 \u091c\u094b \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902, \u091c\u093f\u0938\u0938\u0947 \u092f\u0939 \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u0909\u092a\u091a\u093e\u0930\u094b\u0902 \u092e\u0947\u0902 \u0938\u092c\u0938\u0947 \u0906\u092e \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0932\u0915\u094d\u0937\u094d\u092f \u092c\u0928 \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u0915\u0947 \u0932\u093f\u090f \u0905\u0924\u094d\u092f\u093e\u0927\u0941\u0928\u093f\u0915 \u0909\u092a\u091a\u093e\u0930 \u091a\u093e\u0939\u0928\u0947 \u0935\u093e\u0932\u0947 \u0915\u0908 \u092a\u0930\u093f\u0935\u093e\u0930\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0907\u0938\u0947 \u0905\u0924\u094d\u092f\u0927\u093f\u0915 \u092a\u094d\u0930\u093e\u0938\u0902\u0917\u093f\u0915 \u092c\u0928\u093e\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"deletions-amenable-for-exon-44-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0935\u093f\u0932\u094b\u092a\u0928<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u093e \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u090f\u0915 \u0909\u092a\u0938\u092e\u0942\u0939 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0932\u0915\u094d\u0937\u093f\u0924 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0930\u0923\u0928\u0940\u0924\u093f \u0915\u093e \u092a\u094d\u0930\u0924\u093f\u0928\u093f\u0927\u093f\u0924\u094d\u0935 \u0915\u0930\u0924\u093e \u0939\u0948, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0909\u0928 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u091c\u093f\u0928\u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902\u0964<\/strong>: 3-50, 4-50, 5-50, 6-50, 9-50, 10-50, 11-50, 13-50, 14-50, 15-50, 16-50, 17-50, 19-50, 21-50, 23-50, 24-50, 25-50, 26-50, 27-50, 28-50, 29-50,  30-50, 31-50, 32-50, 33-50, 34-50, 35-50, 36-50, 37-50, 38-50, 39-50, 40-50, 41-50, 42-50, 43-50, 45-50, 47-50, 48-50, 49-50, 50, 52, 52-61, 52-63, 52-64, 52-66, 52-76.<\/p>\n\n\n\n<div><a href=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg\" class=\"td-modal-image\"><figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"847\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg\" alt=\"\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928\" class=\"wp-image-4526\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg 847w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-248x300.jpg 248w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-768x929.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1270x1536.jpg 1270w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1693x2048.jpg 1693w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-10x12.jpg 10w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-347x420.jpg 347w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-150x181.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-300x363.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-696x842.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1068x1292.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1920x2323.jpg 1920w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping.jpg 1984w\" sizes=\"(max-width: 847px) 100vw, 847px\" \/><\/figure><\/a><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/dmdwarrior.com\/hi\/duchenne-exon-deletion-tool\/\">\u0939\u092e\u093e\u0930\u0947 \u090f\u0915\u094d\u0938\u0949\u0928 \u0935\u093f\u0932\u094b\u092a\u0928 \u0916\u094b\u091c \u0909\u092a\u0915\u0930\u0923 \u0915\u0940 \u0916\u094b\u091c \u0915\u0930\u0947\u0902<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0909\u092e\u094d\u092e\u0940\u0926\u0935\u093e\u0930 \u092c\u0928\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f, \u0930\u094b\u0917\u0940 \u092e\u0947\u0902 \u092b\u094d\u0930\u0947\u092e\u0936\u093f\u092b\u094d\u091f\u093f\u0902\u0917 \u0935\u093f\u0932\u094b\u092a\u0928 \u0939\u094b\u0928\u093e \u091a\u093e\u0939\u093f\u090f, \u091c\u093f\u0938\u0947 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c \u0915\u0930 \u0920\u0940\u0915 \u0915\u093f\u092f\u093e \u091c\u093e \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u0932\u0915\u094d\u0937\u094d\u092f \u0921\u0940\u090f\u092e\u0921\u0940 \u091c\u0940\u0928 \u0915\u094b \u0938\u0939\u0940 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u092e\u0947\u0902 \u0935\u093e\u092a\u0938 \u0932\u093e\u0928\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"common-deletions-amenable-to-exon-51-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u092f\u094b\u0917\u094d\u092f \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0935\u093f\u0932\u094b\u092a\u0928<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0926\u093f \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u092e\u0947\u0902 \u0938\u0947 \u0915\u093f\u0938\u0940 \u090f\u0915 \u0935\u093f\u0932\u094b\u092a\u0928 \u0915\u094b \u0926\u0930\u094d\u0936\u093e\u0924\u093e \u0939\u0948, \u0924\u094b \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0932\u093e\u0917\u0942 \u0939\u094b \u0938\u0915\u0924\u0940 \u0939\u0948:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 50 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 48\u201350 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 47\u201350 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 49\u201350 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 52 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 52\u201363 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928<\/li>\n\n\n\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 45-50 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928 (\u0915\u0941\u091b \u092e\u093e\u092e\u0932\u094b\u0902 \u092e\u0947\u0902 \u092b\u094d\u0930\u0947\u092e \u0938\u094d\u0925\u093f\u0924\u093f \u092a\u0930 \u0928\u093f\u0930\u094d\u092d\u0930 \u0915\u0930\u0924\u093e \u0939\u0948)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0947 \u0935\u093f\u0932\u094b\u092a\u0928 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u0915\u094b \u0907\u0938 \u0924\u0930\u0939 \u0938\u0947 \u092c\u093e\u0927\u093f\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902 \u0915\u093f \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0915\u0930 \u0907\u0938\u0947 \u092c\u0939\u093e\u0932 \u0915\u093f\u092f\u093e \u091c\u093e \u0938\u0915\u0924\u093e \u0939\u0948, \u091c\u093f\u0938\u0938\u0947 \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u0930\u0942\u092a \u0938\u0947 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0939\u094b\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"mutations-amenable-to-exon-44-skipping\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u094b \u091b\u094b\u0921\u093c\u0928\u0947 \u092f\u094b\u0917\u094d\u092f \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u090f\u0915\u094d\u0938\u0949\u0928 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902<\/strong>: 3-50, 4-50, 5-50, 6-50, 9-50, 10-50, 11-50, 13-50, 14-50, 15-50, 16-50, 17-50, 19-50, 21-50, 23-50, 24-50, 25-50, 26-50, 27-50, 28-50, 29-50,  30-50, 31-50, 32-50, 33-50, 34-50, 35-50, 36-50, 37-50, 38-50, 39-50, 40-50, 41-50, 42-50, 43-50, 45-50, 47-50, 48-50, 49-50, 50, 52, 52-61, 52-63, 52-64, 52-66, 52-76.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"potential-benefits-of-exon-44-skipping-for-dmd-patients\">\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940: \u0915\u094d\u092f\u093e \u0905\u092a\u0947\u0915\u094d\u0937\u093e \u0915\u0930\u0947\u0902<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0905\u0917\u0930 \u0906\u092a\u0915\u093e \u092c\u091a\u094d\u091a\u093e \u092f\u094b\u0917\u094d\u092f \u0939\u0948, \u0924\u094b \u090f\u091f\u0947\u092a\u094d\u0932\u093f\u0930\u094d\u0938\u0928 \u090f\u0915 \u0935\u093f\u0915\u0932\u094d\u092a \u0939\u094b \u0938\u0915\u0924\u093e \u0939\u0948\u0964 \u092f\u0939 \u0925\u0947\u0930\u0947\u092a\u0940 \u0938\u093e\u092a\u094d\u0924\u093e\u0939\u093f\u0915 \u0905\u0902\u0924\u0903\u0936\u093f\u0930\u093e \u0938\u0902\u0915\u094d\u0930\u092e\u0923 \u0915\u0947 \u092e\u093e\u0927\u094d\u092f\u092e \u0938\u0947 \u0926\u0940 \u091c\u093e\u0924\u0940 \u0939\u0948 \u0914\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0947 \u0915\u094d\u0937\u0930\u0923 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u094b \u0927\u0940\u092e\u093e \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u0940 \u0917\u0908 \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u092b\u093c\u093e\u092f\u0926\u0947:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0930\u094b\u0917 \u0915\u0940 \u0927\u0940\u092e\u0940 \u092a\u094d\u0930\u0917\u0924\u093f<\/li>\n\n\n\n<li>\u092c\u0947\u0939\u0924\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928<\/li>\n\n\n\n<li>\u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u0914\u0930 \u092b\u0947\u092b\u0921\u093c\u094b\u0902 \u0915\u0947 \u0915\u093e\u0930\u094d\u092f \u0915\u093e \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u0938\u0902\u0930\u0915\u094d\u0937\u0923<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0938\u0940\u092e\u093e\u090f\u0901:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u092f\u0939 \u0915\u094b\u0908 \u0907\u0932\u093e\u091c \u0928\u0939\u0940\u0902 \u0939\u0948, \u092c\u0932\u094d\u0915\u093f \u0930\u094b\u0917-\u0938\u0902\u0936\u094b\u0927\u0928 \u0909\u092a\u091a\u093e\u0930 \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u0915\u0947\u0935\u0932 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0932\u0902\u0918\u0928 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0915\u093e\u092e \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u0907\u0938\u0915\u0947 \u0932\u093f\u090f \u0926\u0940\u0930\u094d\u0918\u0915\u093e\u0932\u093f\u0915 \u092a\u094d\u0930\u0924\u093f\u092c\u0926\u094d\u0927\u0924\u093e \u0914\u0930 \u0928\u093f\u092f\u092e\u093f\u0924 \u0905\u0928\u0941\u0935\u0930\u094d\u0924\u0940 \u0915\u093e\u0930\u094d\u0930\u0935\u093e\u0908 \u0915\u0940 \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e \u0939\u094b\u0924\u0940 \u0939\u0948\u0964<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"summary-is-your-child-a-candidate-for-exon-51-skipping\">\u0938\u093e\u0930\u093e\u0902\u0936: \u0915\u094d\u092f\u093e \u0906\u092a\u0915\u093e \u092c\u091a\u094d\u091a\u093e \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u092e\u094d\u092e\u0940\u0926\u0935\u093e\u0930 \u0939\u0948?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u092f\u0926\u093f \u0906\u092a\u0915\u0947 \u092c\u091a\u094d\u091a\u0947 \u0915\u094b \u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u093e \u0928\u093f\u0926\u093e\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948 \u0914\u0930 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0915\u0947 \u092a\u093e\u0938 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0939\u0948, \u091c\u0948\u0938\u0947 \u0915\u093f \u090f\u0915\u094d\u0938\u0949\u0928 50 \u092f\u093e \u090f\u0915\u094d\u0938\u0949\u0928 52 \u0915\u093e \u0935\u093f\u0932\u094b\u092a\u0928, \u0924\u094b \u0938\u0902\u092d\u093e\u0935\u0928\u093e \u0939\u0948 \u0915\u093f \u0909\u0928\u094d\u0939\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0938\u0947 \u0932\u093e\u092d \u0939\u094b \u0938\u0915\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\ud83d\udd0d \u092e\u0941\u0916\u094d\u092f \u092c\u093e\u0924\u0947\u0902:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0935\u093f\u0936\u093f\u0937\u094d\u091f \u0935\u093f\u0932\u094b\u092a\u0928 \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u0915\u094b \u092c\u0939\u093e\u0932 \u0915\u0930\u0928\u0947 \u092e\u0947\u0902 \u092e\u0926\u0926 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u0932\u0917\u092d\u0917 13% DMD \u0930\u094b\u0917\u0940 \u092a\u093e\u0924\u094d\u0930 \u0939\u0948\u0902\u0964<\/li>\n\n\n\n<li>\u092a\u093e\u0924\u094d\u0930\u0924\u093e \u0928\u093f\u0930\u094d\u0927\u093e\u0930\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0906\u0935\u0936\u094d\u092f\u0915 \u0939\u0948\u0964<\/li>\n\n\n\n<li>\u090f\u091f\u0947\u092a\u094d\u0932\u093f\u0930\u094d\u0938\u0947\u0928 \u091c\u0948\u0938\u0940 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u092a\u0926\u094d\u0927\u0924\u093f\u092f\u093e\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 51-\u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f FDA-\u0905\u0928\u0941\u092e\u094b\u0926\u093f\u0924 \u0939\u0948\u0902\u0964<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/hi\/exon-51-skipping-therapies-dmd\/\">\u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0906\u0917\u093e\u092e\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Duchenne Muscular Dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene, which leads to the absence or near absence of dystrophin, a critical protein for muscle strength and stability. However, for certain individuals, promising treatments such as exon skipping therapies offer hope\u2014especially exon 51 skipping, which is the most commonly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4524,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[122,193,421,194,77,178],"class_list":["post-4518","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dmd","tag-exon-51","tag-exon-51-skipping","tag-exon-51-skipping-therapy","tag-exon-51-treatment","tag-exon-skipping","tag-exon-skipping-therapies"],"subtitle":"\u0915\u094d\u092f\u093e \u092e\u0947\u0930\u093e \u092c\u0947\u091f\u093e \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0939\u0948? \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928\u094b\u0902 \u0915\u0947 \u092c\u093e\u0930\u0947 \u092e\u0947\u0902 \u091c\u093e\u0928\u0947\u0902\u0964 \u0915\u094c\u0928 \u0938\u0947 \u090f\u0915\u094d\u0938\u0949\u0928 \u0935\u093f\u0932\u094b\u092a\u0928 \u090f\u0915\u094d\u0938\u0949\u0928 51 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u092f\u0941\u0915\u094d\u0924 \u0939\u0948\u0902?","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=4518"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4518\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/4524"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=4518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=4518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=4518"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}