{"id":4466,"date":"2025-09-10T14:49:23","date_gmt":"2025-09-10T11:49:23","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4466"},"modified":"2025-09-10T15:50:17","modified_gmt":"2025-09-10T12:50:17","slug":"avidity-biosciences-del-zota-increase-dystrophin-phase-1-2-clinical-trial","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/avidity-biosciences-del-zota-increase-dystrophin-phase-1-2-clinical-trial\/","title":{"rendered":"\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e (\u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940) \u0928\u0947 \u091a\u0930\u0923 1\/2 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u092a\u094d\u0930\u092e\u0941\u0916 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0905\u0902\u0924 \u092c\u093f\u0902\u0926\u0941\u0913\u0902 \u092a\u0930 \u0930\u094b\u0917 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u094b \u0909\u0932\u091f\u0928\u0947 \u0915\u093e \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 \u0915\u093f\u092f\u093e"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Avidity Biosciences \u0928\u0947 EXPLORE44 \u0914\u0930 EXPLORE44-OLE \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u092e\u0947\u0902 \u090f\u0915 \u0935\u0930\u094d\u0937 \u0924\u0915 \u0932\u0917\u093e\u0924\u093e\u0930 del-zota \u0938\u0947 \u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0938\u0915\u093e\u0930\u093e\u0924\u094d\u092e\u0915 \u0928\u090f \u0906\u0901\u0915\u0921\u093c\u094b\u0902 \u0915\u0940 \u0918\u094b\u0937\u0923\u093e \u0915\u0940\u0964 \u0907\u0928 \u0906\u0901\u0915\u0921\u093c\u094b\u0902 \u0928\u0947 \u0930\u094b\u0917 \u0915\u0940 \u092a\u094d\u0930\u0917\u0924\u093f \u092e\u0947\u0902 \u0909\u0932\u091f\u092b\u0947\u0930 \u0914\u0930 \u0915\u0908 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u092e\u093e\u092a\u094b\u0902 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930\u092d\u0942\u0924 \u0914\u0930 \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 \u0905\u092d\u0942\u0924\u092a\u0942\u0930\u094d\u0935 \u0938\u0941\u0927\u093e\u0930 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0915\u093f\u092f\u093e\u0964 EXPLORE44 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924 \u0906\u0901\u0915\u0921\u093c\u0947 \u0906\u0917\u093e\u092e\u0940 \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0938\u092e\u094d\u092e\u0947\u0932\u0928\u094b\u0902 \u092e\u0947\u0902 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0915\u093f\u090f \u091c\u093e\u090f\u0901\u0917\u0947\u0964 \u2013 \u0914\u0930 \u092a\u0922\u093c\u0947\u0902: <a href=\"https:\/\/dmdwarrior.com\/hi\/fda-designates-avidity-biosciences-delpacibart-zotadirsen-del-zota-as-a-breakthrough-therapy-for-the-treatment-of-dmd-in-individuals-with-mutations-that-allow-for-exon-44-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u092c\u094d\u0930\u0947\u0915\u0925\u094d\u0930\u0942 \u0925\u0947\u0930\u0947\u092a\u0940: \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917<\/a> \u2013<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#del-zota-exon-44-skipping-therapy\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e: \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/li><li><a href=\"#del-zota-phase-1-2-clinical-trial\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e: \u091a\u0930\u0923 1\/2 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/a><\/li><li><a href=\"#biologics-license-application-bla-to-fda\">FDA \u0915\u0947 \u0932\u093f\u090f \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u093f\u0915\u094d\u0938 \u0932\u093e\u0907\u0938\u0947\u0902\u0938 \u0906\u0935\u0947\u0926\u0928 (BLA)<\/a><\/li><li><a href=\"#explore-44-exon-44-skipping-program\">EXPLORE44: \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u092a\u094d\u0930\u094b\u0917\u094d\u0930\u093e\u092e<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"del-zota-exon-44-skipping-therapy\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e: \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0921\u0940\u090f\u092e\u0921\u0940 \u090f\u0915 \u0926\u0941\u0930\u094d\u0932\u092d \u0906\u0928\u0941\u0935\u0902\u0936\u093f\u0915 \u0938\u094d\u0925\u093f\u0924\u093f \u0939\u0948, \u091c\u093f\u0938\u092e\u0947\u0902 \u091c\u0928\u094d\u092e \u0938\u0947 \u0939\u0940 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u0940 \u0905\u0928\u0941\u092a\u0938\u094d\u0925\u093f\u0924\u093f \u0915\u0947 \u0915\u093e\u0930\u0923 \u092c\u0939\u0941\u0924 \u0915\u092e \u0909\u092e\u094d\u0930 \u0938\u0947 \u0939\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u092a\u094d\u0930\u0917\u0924\u093f\u0936\u0940\u0932 \u0915\u094d\u0937\u0924\u093f \u0914\u0930 \u0915\u092e\u091c\u094b\u0930\u0940 \u0936\u0941\u0930\u0942 \u0939\u094b \u091c\u093e\u0924\u0940 \u0939\u0948\u0964 <strong>\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e \u0915\u094b \u092b\u0949\u0938\u094d\u092b\u094b\u0930\u094b\u0921\u093e\u092f\u092e\u093f\u0921\u0947\u091f \u092e\u0949\u0930\u094d\u092b\u094b\u0932\u093f\u0928\u094b \u0911\u0932\u093f\u0917\u094b\u092e\u0930\u094d\u0938 (\u092a\u0940\u090f\u092e\u0913) \u0915\u094b \u0915\u0902\u0915\u093e\u0932 \u0915\u0940 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0914\u0930 \u0939\u0943\u0926\u092f \u0915\u0947 \u090a\u0924\u0915\u094b\u0902 \u0924\u0915 \u092a\u0939\u0941\u0902\u091a\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u0924\u093e\u0915\u093f \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u090f\u092e\u0906\u0930\u090f\u0928\u090f \u0915\u0947 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0915\u094b \u091b\u094b\u0921\u093c \u0926\u093f\u092f\u093e \u091c\u093e \u0938\u0915\u0947 \u0914\u0930 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915, \u0932\u0917\u092d\u0917 \u092a\u0942\u0930\u094d\u0923 \u0932\u0902\u092c\u093e\u0908 \u0935\u093e\u0932\u0947 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0938\u0902\u092d\u0935 \u0939\u094b \u0938\u0915\u0947\u0964<\/strong> \u0932\u0917\u092d\u0917 \u092a\u0942\u0930\u094d\u0923 \u0932\u0902\u092c\u093e\u0908 \u0935\u093e\u0932\u093e \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092a\u094d\u0930\u092e\u0941\u0916 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0921\u094b\u092e\u0947\u0928 \u0915\u094b \u092c\u0930\u0915\u0930\u093e\u0930 \u0930\u0916\u0924\u093e \u0939\u0948 \u0914\u0930 \u0921\u0940\u090f\u092e\u0921\u094044 \u0915\u0947 \u0938\u093e\u0925 \u0930\u0939\u0928\u0947 \u0935\u093e\u0932\u0947 \u0932\u094b\u0917\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u092c\u0947\u0939\u0924\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930 \u0938\u0915\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"del-zota-phase-1-2-clinical-trial\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e: \u091a\u0930\u0923 1\/2 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0932\u0917\u092d\u0917 \u090f\u0915 \u0935\u0930\u094d\u0937 \u092e\u0947\u0902 \u092b\u0930\u094d\u0936 \u0938\u0947 \u0909\u0920\u0928\u0947 \u0915\u093e \u0938\u092e\u092f (\u091f\u0940\u091f\u0940\u0906\u0930), 4-\u0938\u0940\u0922\u093c\u0940 \u091a\u0922\u093c\u0928\u093e (4\u090f\u0938\u0938\u0940), \u090a\u092a\u0930\u0940 \u0905\u0902\u0917 \u0915\u093e \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 (\u092a\u0940\u092f\u0942\u090f\u0932) \u0914\u0930 10-\u092e\u0940\u091f\u0930 \u091a\u0932\u0928\u093e\/\u0926\u094c\u0921\u093c\u0928\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923 (10\u090f\u092e\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u0906\u0930\u091f\u0940) \u0938\u0939\u093f\u0924 \u0915\u0908 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u092e\u093e\u092a\u094b\u0902 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0914\u0930 \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 \u0905\u092d\u0942\u0924\u092a\u0942\u0930\u094d\u0935 \u0938\u0941\u0927\u093e\u0930<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (CK) \u092e\u0947\u0902 \u0905\u092d\u0942\u0924\u092a\u0942\u0930\u094d\u0935 \u0924\u0947\u091c\u0940 \u0938\u0947 \u0915\u092e\u0940, \u091c\u094b 16 \u092e\u0939\u0940\u0928\u0947 \u0915\u0947 \u0905\u0928\u0941\u0935\u0930\u094d\u0924\u0940 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u0932\u0917\u092d\u0917 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u094d\u0924\u0930 \u092a\u0930 \u092c\u0928\u0940 \u0930\u0939\u0940 \u0914\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092e\u0947\u0902 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u0947 25% \u0915\u0940 \u0935\u0943\u0926\u094d\u0927\u093f, \u091c\u094b \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u092b\u093e\u0907\u092c\u0930 \u0915\u0940 \u0928\u093f\u0930\u0902\u0924\u0930 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0915\u094b \u0926\u0930\u094d\u0936\u093e\u0924\u0940 \u0939\u0948\u0964<\/strong><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u090f\u0935\u093f\u0921\u093f\u091f\u0940 \u0924\u094d\u0935\u0930\u093f\u0924 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u0915\u0947 \u0932\u093f\u090f 2025 \u0915\u0947 \u0905\u0902\u0924 \u0924\u0915 \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u093f\u0915\u094d\u0938 \u0932\u093e\u0907\u0938\u0947\u0902\u0938 \u0906\u0935\u0947\u0926\u0928 (\u092c\u0940\u090f\u0932\u090f) \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0924\u0948\u092f\u093e\u0930 \u0939\u0948<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"biologics-license-application-bla-to-fda\">FDA \u0915\u0947 \u0932\u093f\u090f \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u093f\u0915\u094d\u0938 \u0932\u093e\u0907\u0938\u0947\u0902\u0938 \u0906\u0935\u0947\u0926\u0928 (BLA)<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u090f\u0935\u093f\u0921\u093f\u091f\u0940 \u0915\u0940 \u0905\u0927\u094d\u092f\u0915\u094d\u0937 \u0914\u0930 \u092e\u0941\u0916\u094d\u092f \u0915\u093e\u0930\u094d\u092f\u0915\u093e\u0930\u0940 \u0905\u0927\u093f\u0915\u093e\u0930\u0940 \u0938\u093e\u0930\u093e \u092c\u0949\u092f\u0938 \u0928\u0947 \u0915\u0939\u093e, &quot;\u092a\u0939\u0932\u0940 \u092c\u093e\u0930, \u0939\u092e\u093e\u0930\u0947 \u092a\u093e\u0938 \u0921\u0947\u091f\u093e \u0939\u0948 \u091c\u094b \u0926\u0930\u094d\u0936\u093e\u0924\u093e \u0939\u0948 \u0915\u093f \u0928\u093f\u0930\u0902\u0924\u0930 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u0938\u0902\u0930\u0915\u094d\u0937\u0923 \u0938\u0947 \u0921\u0940\u090f\u092e\u0921\u0940 \u092e\u0947\u0902 \u0915\u0908 \u092a\u094d\u0930\u092e\u0941\u0916 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0909\u092a\u093e\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u093e\u0930\u094d\u0925\u0915 \u0938\u0941\u0927\u093e\u0930 \u0939\u094b\u0924\u093e \u0939\u0948\u0964&quot;<strong>\u092f\u0947 \u0905\u092d\u0942\u0924\u092a\u0942\u0930\u094d\u0935 \u0906\u0902\u0915\u0921\u093c\u0947 \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0924\u0915 \u0938\u0940\u0927\u0947 \u0906\u0930\u090f\u0928\u090f \u092a\u0939\u0941\u0902\u091a\u093e\u0928\u0947 \u0915\u0947 \u0939\u092e\u093e\u0930\u0947 \u0915\u094d\u0930\u093e\u0902\u0924\u093f\u0915\u093e\u0930\u0940 \u0932\u0915\u094d\u0937\u093f\u0924 \u0926\u0943\u0937\u094d\u091f\u093f\u0915\u094b\u0923 \u0915\u0947 \u092a\u094d\u0930\u092d\u093e\u0935 \u0915\u094b \u0930\u0947\u0916\u093e\u0902\u0915\u093f\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964<\/strong> \u0939\u092e del-zota \u0935\u093f\u0915\u093e\u0938 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u0915\u094b \u0924\u0947\u091c\u093c\u0940 \u0938\u0947 \u0906\u0917\u0947 \u092c\u0922\u093c\u093e\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0924\u0924\u094d\u092a\u0930\u0924\u093e \u0938\u0947 \u0915\u093e\u092e \u0915\u0930 \u0930\u0939\u0947 \u0939\u0948\u0902 \u0914\u0930 2025 \u0915\u0947 \u0905\u0902\u0924 \u0924\u0915 \u0924\u094d\u0935\u0930\u093f\u0924 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u0915\u0947 \u0932\u093f\u090f FDA \u0915\u0947 \u0932\u093f\u090f \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u093f\u0915\u094d\u0938 \u0932\u093e\u0907\u0938\u0947\u0902\u0938 \u0906\u0935\u0947\u0926\u0928 (BLA) \u091c\u092e\u093e \u0915\u0930\u0928\u0947 \u0915\u0940 \u0926\u093f\u0936\u093e \u092e\u0947\u0902 \u0906\u0917\u0947 \u092c\u0922\u093c \u0930\u0939\u0947 \u0939\u0948\u0902\u0964 \u0939\u092e \u0907\u0938 \u0928\u093f\u0930\u094d\u092e\u092e \u0914\u0930 \u0935\u093f\u0928\u093e\u0936\u0915\u093e\u0930\u0940 \u092c\u0940\u092e\u093e\u0930\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0928\u090f \u0909\u092a\u091a\u093e\u0930 \u0935\u093f\u0915\u0932\u094d\u092a \u0915\u0940 \u0916\u094b\u091c \u092e\u0947\u0902, \u0905\u0928\u094d\u0935\u0947\u0937\u0915\u094b\u0902 \u0914\u0930 \u0909\u0928\u0915\u0940 \u091f\u0940\u092e\u094b\u0902, \u0914\u0930 \u0938\u092c\u0938\u0947 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923, \u0939\u092e\u093e\u0930\u0947 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u092e\u0947\u0902 \u092d\u093e\u0917 \u0932\u0947\u0928\u0947 \u0935\u093e\u0932\u094b\u0902 \u0914\u0930 \u0909\u0928\u0915\u0947 \u092a\u0930\u093f\u0935\u093e\u0930\u094b\u0902 \u0915\u0947 \u0928\u093f\u0930\u0902\u0924\u0930 \u0938\u092e\u0930\u094d\u092a\u0923 \u0915\u0947 \u0932\u093f\u090f \u0905\u092a\u0928\u0940 \u0917\u0939\u0930\u0940 \u0915\u0943\u0924\u091c\u094d\u091e\u0924\u093e \u0935\u094d\u092f\u0915\u094d\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"explore-44-exon-44-skipping-program\">EXPLORE44: \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u092a\u094d\u0930\u094b\u0917\u094d\u0930\u093e\u092e<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>del-zota \u0938\u0947 \u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092e\u0947\u0902 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u0947 \u0932\u0917\u092d\u0917 25 \u092a\u094d\u0930\u0924\u093f\u0936\u0924 \u0915\u0940 \u0938\u093e\u0902\u0916\u094d\u092f\u093f\u0915\u0940\u092f \u0930\u0942\u092a \u0938\u0947 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0935\u0943\u0926\u094d\u0927\u093f \u0926\u0947\u0916\u0940 \u0917\u0908 \u0924\u0925\u093e \u0915\u0941\u0932 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u093e \u0938\u094d\u0924\u0930 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u0947 58 \u092a\u094d\u0930\u0924\u093f\u0936\u0924 \u0924\u0915 \u092c\u0939\u093e\u0932 \u0939\u094b \u0917\u092f\u093e\u0964<\/strong> \u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (CK) \u0915\u093e \u0938\u094d\u0924\u0930 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 80 \u092a\u094d\u0930\u0924\u093f\u0936\u0924 \u0938\u0947 \u092d\u0940 \u091c\u093c\u094d\u092f\u093e\u0926\u093e \u0924\u0947\u091c\u093c\u0940 \u0938\u0947 \u0915\u092e \u0939\u0941\u0906 \u0914\u0930 \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0940 \u092a\u0942\u0930\u0940 \u0905\u0935\u0927\u093f \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u0932\u0917\u092d\u0917 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u094d\u0924\u0930 \u092a\u0930 \u092c\u0928\u093e \u0930\u0939\u093e, \u0914\u0930 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u093e 16 \u092e\u0939\u0940\u0928\u0947 \u0924\u0915 \u0932\u0917\u093e\u0924\u093e\u0930 \u0928\u093f\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u093f\u092f\u093e \u0917\u092f\u093e\u0964 \u0907\u0938\u0915\u0947 \u0905\u0924\u093f\u0930\u093f\u0915\u094d\u0924, \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u090f\u0915 \u0935\u0930\u094d\u0937 \u092c\u093e\u0926 50 \u092a\u094d\u0930\u0924\u093f\u0936\u0924 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u093e CK \u0938\u094d\u0924\u0930 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u0940\u092e\u093e \u0915\u0947 \u092d\u0940\u0924\u0930 \u0930\u0939\u093e\u0964 <a href=\"https:\/\/dmdwarrior.com\/hi\/what-is-creatine-kinase-ck\/\" target=\"_blank\" data-type=\"post\" data-id=\"2167\" rel=\"noreferrer noopener\">\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (CK) \u0915\u094d\u092f\u093e \u0939\u0948?<\/a> \u2013<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0915\u0941\u0932 17 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 (12 \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e \u0914\u0930 5 \u0917\u0948\u0930-\u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e) \u0915\u093e \u0932\u0917\u092d\u0917 \u090f\u0915 \u0935\u0930\u094d\u0937 \u0924\u0915 \u0905\u0928\u0941\u0938\u0930\u0923 \u0915\u093f\u092f\u093e \u0917\u092f\u093e, \u091c\u093f\u0928\u094d\u0939\u094b\u0902\u0928\u0947 EXPLORE44\u00ae \u0915\u0947 del-zota \u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u0938\u092e\u0942\u0939 \u0938\u0947 \u0936\u0941\u0930\u0941\u0906\u0924 \u0915\u0940 \u0914\u0930 EXPLORE44-OLE\u2122 \u0924\u0915 \u091c\u093e\u0930\u0940 \u0930\u0916\u093e\u0964 \u0905\u0927\u094d\u092f\u092f\u0928 \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u094b \u0926\u0947\u0916\u0924\u0947 \u0939\u0941\u090f, \u0915\u0941\u091b \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u094b EXPLORE44 \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 \u0939\u0930 \u091b\u0939 \u0939\u092b\u093c\u094d\u0924\u0947 \u092e\u0947\u0902 \u090f\u0915 \u092c\u093e\u0930 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e (Q6W) \u0914\u0930 \u0915\u0941\u091b \u0915\u094b \u0939\u0930 \u0906\u0920 \u0939\u092b\u093c\u094d\u0924\u0947 \u092e\u0947\u0902 \u090f\u0915 \u092c\u093e\u0930 10 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0926\u093f\u092f\u093e \u0917\u092f\u093e\u0964 \u0938\u092d\u0940 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u094b EXPLORE44-OLE \u0915\u0947 \u0926\u094c\u0930\u093e\u0928 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e (Q6W) \u0916\u0941\u0930\u093e\u0915 \u0905\u0928\u0941\u0938\u0942\u091a\u0940 \u092e\u0947\u0902 \u0938\u094d\u0925\u093e\u0928\u093e\u0902\u0924\u0930\u093f\u0924 \u0915\u0930 \u0926\u093f\u092f\u093e \u0917\u092f\u093e\u0964 \u0938\u092d\u0940 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u0940 \u0938\u092d\u0940 \u0906\u0915\u0932\u0928 \u092a\u0942\u0930\u0947 \u0928\u0939\u0940\u0902 \u0915\u0930 \u0938\u0915\u0947\u0964 del-zota \u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0907\u0928 \u090f\u0915\u0924\u094d\u0930\u093f\u0924 \u0916\u0941\u0930\u093e\u0915 \u0938\u092e\u0942\u0939\u094b\u0902 \u0938\u0947 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0906\u0902\u0915\u0921\u093c\u094b\u0902 \u0915\u0940 \u0924\u0941\u0932\u0928\u093e DMD44 \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 (PRO-DMD-01) \u0938\u0947 \u0915\u0940 \u0917\u0908, \u091c\u093f\u0938\u0938\u0947 \u0938\u0941\u0927\u093e\u0930 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0939\u0941\u0906:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>4-\u0938\u0940\u0922\u093c\u0940 \u091a\u0922\u093c\u093e\u0908 (4SC)<\/strong>: \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 2.1 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930 \u0939\u0941\u0906\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 2.7 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908 (DMD44 Nat Hx N=22; del-zota N=10)\u0964<\/li>\n\n\n\n<li><strong>10-\u092e\u0940\u091f\u0930 \u0935\u0949\u0915\/\u0930\u0928 \u091f\u0947\u0938\u094d\u091f (10mWRT)<\/strong>: \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 0.7 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930 \u0939\u0941\u0906\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 1.5 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908 (DMD44 Nat Hx N=22; del-zota N=10)\u0964<\/li>\n\n\n\n<li><strong>\u092b\u0930\u094d\u0936 \u0938\u0947 \u0909\u0920\u0928\u0947 \u0915\u093e \u0938\u092e\u092f (\u091f\u0940\u091f\u0940\u0906\u0930)<\/strong>: \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 3.2 \u0938\u0947\u0915\u0902\u0921 \u0915\u093e \u0938\u0941\u0927\u093e\u0930 \u0939\u0941\u0906\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 1.6 \u0938\u0947\u0915\u0902\u0921 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908 (\u0921\u0940\u090f\u092e\u0921\u0940 \u0928\u0947\u091f \u090f\u091a\u090f\u0915\u094d\u0938 \u090f\u0928=19; 1\u091f\u0940\u092a\u094088\u091f\u0940 \u090f\u0928=6)\u0964<\/li>\n\n\n\n<li><strong>\u0928\u0949\u0930\u094d\u0925 \u0938\u094d\u091f\u093e\u0930 \u090f\u0902\u092c\u0941\u0932\u0947\u091f\u0930\u0940 \u0905\u0938\u0947\u0938\u092e\u0947\u0902\u091f (\u090f\u0928\u090f\u0938\u090f\u090f)<\/strong>\u0938\u094d\u0925\u093f\u0930 \u0930\u0939\u093e\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 2.4 \u0905\u0902\u0915\u094b\u0902 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908 (DMD44 Nat Hx N=20; del-zota N=10)\u0964<\/li>\n\n\n\n<li><strong>\u090a\u092a\u0930\u0940 \u0905\u0902\u0917 \u0915\u093e \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 (PUL2)<\/strong>: \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 1.5 \u0905\u0902\u0915\u094b\u0902 \u0915\u093e \u0938\u0941\u0927\u093e\u0930 \u0939\u0941\u0906\u0964 \u0907\u0938\u0915\u0947 \u0935\u093f\u092a\u0930\u0940\u0924, \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0938\u0947 0.7 \u0905\u0902\u0915\u094b\u0902 \u0915\u0940 \u0917\u093f\u0930\u093e\u0935\u091f \u0906\u0908\u0964 ii \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e \u0914\u0930 \u0928 \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e, \u0926\u094b\u0928\u094b\u0902 \u0924\u0930\u0939 \u0915\u0947 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u092e\u093e\u0928 PUL \u0938\u0941\u0927\u093e\u0930 \u0926\u0947\u0916\u0947 \u0917\u090f (DMD44 Nat Hx N=27; del-zota N=17)\u0964<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>EXPLORE44-OLE \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u092e\u0947\u0902 \u0938\u092d\u0940 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e, \u0914\u0930 del-zota \u0928\u0947 \u0926\u0940\u0930\u094d\u0918\u0915\u093e\u0932\u093f\u0915 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e \u092a\u094d\u0930\u094b\u092b\u093c\u093e\u0907\u0932 \u0915\u093e \u0905\u0928\u0941\u0915\u0942\u0932 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u0928 \u091c\u093e\u0930\u0940 \u0930\u0916\u093e\u0964<\/strong> \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u0909\u092a\u091a\u093e\u0930 \u0906\u0915\u0938\u094d\u092e\u093f\u0915 \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0918\u091f\u0928\u093e\u090f\u0901 (TEAE) \u0939\u0932\u094d\u0915\u0940 \u092f\u093e \u092e\u0927\u094d\u092f\u092e \u0925\u0940\u0902, \u091c\u093f\u0928\u092e\u0947\u0902 \u0938\u092c\u0938\u0947 \u0906\u092e TEAE (3 \u0938\u0947 \u0905\u0927\u093f\u0915 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0939\u094b\u0928\u0947 \u0935\u093e\u0932\u0940) \u090a\u092a\u0930\u0940 \u0936\u094d\u0935\u0938\u0928 \u092a\u0925 \u0915\u0947 \u0932\u0915\u094d\u0937\u0923, \u0926\u0938\u094d\u0924, \u0917\u093f\u0930\u0928\u093e, \u092a\u0940\u0920 \u0926\u0930\u094d\u0926 \u0914\u0930 \u0938\u093f\u0930\u0926\u0930\u094d\u0926 \u0925\u0947\u0964 \u090f\u0915 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u0940 \u0928\u0947 \u0905\u0924\u093f\u0938\u0902\u0935\u0947\u0926\u0928\u0936\u0940\u0932\u0924\u093e \u0915\u0940 \u0918\u091f\u0928\u093e \u0915\u0947 \u092c\u093e\u0926 EXPLORE44-OLE \u0932\u0947\u0928\u093e \u092c\u0902\u0926 \u0915\u0930 \u0926\u093f\u092f\u093e\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u090f\u0935\u093f\u0921\u093f\u091f\u0940 \u0935\u0930\u094d\u0937 2025 \u0915\u0947 \u0905\u0902\u0924 \u0924\u0915 \u0905\u092e\u0947\u0930\u093f\u0915\u0940 \u0916\u093e\u0926\u094d\u092f \u090f\u0935\u0902 \u0914\u0937\u0927\u093f \u092a\u094d\u0930\u0936\u093e\u0938\u0928 (1\u091f\u0940\u092a\u0940121\u091f\u0940) \u0915\u094b \u092c\u0940\u090f\u0932\u090f \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0924\u0948\u092f\u093e\u0930 \u0939\u0948\u0964<\/strong> \u092f\u0939 \u0915\u0902\u092a\u0928\u0940 \u0926\u094d\u0935\u093e\u0930\u093e 12 \u092e\u0939\u0940\u0928\u0947 \u0915\u0940 \u0905\u0935\u0927\u093f \u092e\u0947\u0902 \u0924\u0940\u0928 \u0928\u093f\u092f\u094b\u091c\u093f\u0924 \u092c\u0940\u090f\u0932\u090f \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u0947 \u092a\u0939\u0932\u0940 \u0939\u094b\u0917\u0940\u0964 \u090f\u0935\u093f\u0921\u093f\u091f\u0940 \u092a\u0942\u0930\u094d\u0923 \u0935\u0948\u0936\u094d\u0935\u093f\u0915 \u0905\u0928\u0941\u092e\u094b\u0926\u0928 \u0915\u0947 \u0938\u092e\u0930\u094d\u0925\u0928 \u0939\u0947\u0924\u0941 \u090f\u0915 \u092a\u0941\u0937\u094d\u091f\u093f\u0915\u0930\u0923 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0940 \u0924\u0948\u092f\u093e\u0930\u0940 \u091c\u093e\u0930\u0940 \u0930\u0916\u0947 \u0939\u0941\u090f \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u092a\u0922\u093c\u0947\u0902<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/hi\/upcoming-exon-44-skipping-therapies-for-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0906\u0917\u093e\u092e\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/hi\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0905\u0928\u0941\u0915\u0942\u0932 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0914\u0930 \u0935\u093f\u0932\u094b\u092a\u0928<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Avidity Biosciences announced positive new data from participants treated continuously with del-zota for one year in the EXPLORE44 and EXPLORE44-OLE trials. These data demonstrated reversal of disease progression and unprecedented improvement compared to baseline and natural history across multiple functional measures. Additional data from the EXPLORE44 program will be presented at upcoming scientific congresses. &#8211; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4468,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[126,298,129,73,141,127,246,299,359],"class_list":["post-4466","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-avidity-biosciences","tag-del-zota","tag-dmd44","tag-dystrophin","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-explore44","tag-full-length-dystrophin"],"subtitle":"del-zota \u0915\u0947 \u0938\u093e\u0925, \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093c\u093f\u0928 \u092e\u0947\u0902 25% \u0915\u0940 \u0935\u0943\u0926\u094d\u0927\u093f \u0939\u0941\u0908 \u0914\u0930 \u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c\u093c \u092e\u0947\u0902 80% \u0915\u0940 \u0915\u092e\u0940 \u0906\u0908\u0964 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940\u091c\u093c \u092e\u0947\u0902, \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u092e\u0947\u0902 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0909\u091a\u094d\u091a\u0924\u092e \u092e\u093e\u0928\u094b\u0902 \u0928\u0947 \u0909\u0924\u094d\u0938\u093e\u0939 \u092a\u0948\u0926\u093e \u0915\u093f\u092f\u093e \u0939\u0948\u0964","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=4466"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/4466\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/4468"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=4466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=4466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=4466"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}