{"id":3876,"date":"2025-05-28T15:54:48","date_gmt":"2025-05-28T12:54:48","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3876"},"modified":"2025-11-03T20:23:36","modified_gmt":"2025-11-03T17:23:36","slug":"entrada-therapeutics-receives-eu-authorization-to-start-exon-45-skipping-clinical-trial-in-duchenne-muscular-dystrophy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/entrada-therapeutics-receives-eu-authorization-to-start-exon-45-skipping-clinical-trial-in-duchenne-muscular-dystrophy\/","title":{"rendered":"Entrada Therapeutics \u0915\u094b \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 45 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u0936\u0941\u0930\u0942 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092f\u0942\u0930\u094b\u092a\u0940\u092f \u0938\u0902\u0918 \u0938\u0947 \u0905\u0928\u0941\u092e\u0924\u093f \u092e\u093f\u0932\u0940"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Entrada Therapeutics \u0928\u0947 \u0906\u091c \u0918\u094b\u0937\u0923\u093e \u0915\u0940 \u0915\u093f \u0909\u0938\u0947 \u092f\u0942\u0930\u094b\u092a\u0940\u092f \u0938\u0902\u0918 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0935\u093f\u0928\u093f\u092f\u092e\u0928 (EU-CTR) \u0915\u0947 \u0905\u0902\u0924\u0930\u094d\u0917\u0924 \u0915\u0908 \u0926\u0947\u0936\u094b\u0902 \u0915\u0947 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u092a\u094d\u0930\u093e\u0927\u093f\u0915\u0930\u0923\u094b\u0902 \u0914\u0930 \u0928\u0948\u0924\u093f\u0915\u0924\u093e \u0938\u092e\u093f\u0924\u093f\u092f\u094b\u0902 \u0938\u0947 ELEVATE-45-201 \u0906\u0930\u0902\u092d \u0915\u0930\u0928\u0947 \u0915\u0940 \u0905\u0928\u0941\u092e\u0924\u093f \u092e\u093f\u0932 \u0917\u0908 \u0939\u0948, \u091c\u094b \u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (DMD) \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0910\u0938\u0947 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092a\u0930 ENTR-601-45 \u0915\u093e \u091a\u0930\u0923 1\/2 \u092c\u0939\u0941 \u0906\u0930\u094b\u0939\u0940 \u0916\u0941\u0930\u093e\u0915 (MAD) \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0927\u094d\u092f\u092f\u0928 \u0939\u0948, \u091c\u094b \u090f\u0915\u094d\u0938\u0949\u0928 45 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0939\u0948\u0902\u0964<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Entrada Therapeutics \u0915\u094b \u092f\u0942\u0930\u094b\u092a\u0940\u092f \u0938\u0902\u0918 \u0915\u093e \u092a\u094d\u0930\u093e\u0927\u093f\u0915\u0930\u0923 \u092a\u094d\u0930\u093e\u092a\u094d\u0924 \u0939\u0941\u0906<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Entrada Therapeutics \u0915\u0947 \u092e\u0941\u0916\u094d\u092f \u0915\u093e\u0930\u094d\u092f\u0915\u093e\u0930\u0940 \u0905\u0927\u093f\u0915\u093e\u0930\u0940 \u0926\u0940\u092a\u0932 \u0926\u094b\u0936\u0940 \u0928\u0947 \u0915\u0939\u093e, &quot;ELEVATE-45-201 \u090f\u0915\u094d\u0938\u0949\u0928 45 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0935\u094d\u092f\u0915\u094d\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0938\u0902\u092f\u0941\u0917\u094d\u092e\u093f\u0924 \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u093e \u0938\u092c\u0938\u0947 \u0909\u0928\u094d\u0928\u0924 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0905\u0927\u094d\u092f\u092f\u0928 \u0939\u0948 \u0914\u0930 \u092f\u0939 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0905\u092a\u0942\u0930\u093f\u0924 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u093e \u0906\u0935\u0936\u094d\u092f\u0915\u0924\u093e\u0913\u0902 \u0935\u093e\u0932\u0947 \u090f\u0915 \u092c\u0921\u093c\u0947 \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u0909\u092a-\u091c\u0928\u0938\u0902\u0916\u094d\u092f\u093e \u0915\u094b \u0938\u0902\u092c\u094b\u0927\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u093e \u0939\u0948\u0964&quot; &quot;\u0908\u092f\u0942 \u092a\u094d\u0930\u093e\u0927\u093f\u0915\u0930\u0923 \u0939\u092e\u093e\u0930\u0947 \u0928\u090f \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e\u094b\u0902 \u0915\u0947 \u092a\u0940\u091b\u0947 \u092c\u0922\u093c\u0924\u0940 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u0917\u0924\u093f \u092a\u0930 \u0906\u0927\u093e\u0930\u093f\u0924 \u0939\u0948\u0964 ELEVATE-44 \u0914\u0930 ELEVATE-45 \u0915\u0947 \u0939\u093e\u0932 \u0915\u0947 \u092a\u094d\u0930\u093e\u0927\u093f\u0915\u0930\u0923\u094b\u0902 \u0914\u0930 \u0907\u0938 \u0935\u0930\u094d\u0937 \u0915\u0947 \u0905\u0902\u0924 \u092e\u0947\u0902 ELEVATE-50 \u0915\u0947 \u0932\u093f\u090f \u0928\u093f\u092f\u094b\u091c\u093f\u0924 \u092b\u093e\u0907\u0932\u093f\u0902\u0917 \u0915\u0947 \u0938\u093e\u0925, \u0939\u092e \u0935\u0930\u094d\u0937 \u0915\u0947 \u0905\u0902\u0924 \u0924\u0915 \u0905\u092a\u0928\u0947 DMD \u092b\u093c\u094d\u0930\u0948\u0902\u091a\u093e\u0907\u091c\u093c \u0915\u0947 \u0926\u093e\u092f\u0930\u0947 \u0915\u093e \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0930\u0942\u092a \u0938\u0947 \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u091f\u094d\u0930\u0948\u0915 \u092a\u0930 \u0939\u0948\u0902\u0964&quot;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u092a\u0922\u093c\u0947\u0902:<\/strong> <a href=\"https:\/\/dmdwarrior.com\/hi\/next-generation-exon-skipping-therapies-for-duchenne-muscular-dystrophy\/\" target=\"_blank\" data-type=\"post\" data-id=\"2468\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0905\u0917\u0932\u0940 \u092a\u0940\u0922\u093c\u0940 \u0915\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u0940 \u0917\u0908<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u090f\u0915\u094d\u0938\u0949\u0928 45 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u091f\u094d\u0930\u093e\u092f\u0932 \u092f\u0942\u0930\u094b\u092a\u0940\u092f \u0938\u0902\u0918 \u092e\u0947\u0902 \u0936\u0941\u0930\u0942 \u0939\u0941\u0906<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ELEVATE-45-201 \u090f\u0915 \u0935\u0948\u0936\u094d\u0935\u093f\u0915, \u0926\u094b-\u092d\u093e\u0917, \u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915, \u0921\u092c\u0932-\u092c\u094d\u0932\u093e\u0907\u0902\u0921 \u092a\u094d\u0932\u0947\u0938\u092c\u094b-\u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u091a\u0930\u0923 1\/2 \u0905\u0927\u094d\u092f\u092f\u0928 \u0939\u0948 \u091c\u094b \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u0915\u0947 \u0938\u093e\u0925 \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 ENTR-601-45 \u0915\u0940 \u0938\u0941\u0930\u0915\u094d\u0937\u093e, \u0938\u0939\u0928\u0940\u092f\u0924\u093e \u0914\u0930 \u092a\u094d\u0930\u092d\u093e\u0935\u0936\u0940\u0932\u0924\u093e \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0924\u093e \u0939\u0948 \u091c\u094b \u090f\u0915\u094d\u0938\u0949\u0928 45 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0939\u0948\u0902\u0964 \u092d\u093e\u0917 A \u090f\u0915 \u092c\u0939\u0941-\u0906\u0930\u094b\u0939\u0940 \u0916\u0941\u0930\u093e\u0915 \u0905\u0927\u094d\u092f\u092f\u0928 \u0939\u0948 \u091c\u093f\u0938\u0947 \u0932\u0917\u092d\u0917 24 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0914\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093c\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0938\u0939\u093f\u0924 \u0938\u0941\u0930\u0915\u094d\u0937\u093e, \u092b\u093c\u093e\u0930\u094d\u092e\u093e\u0915\u094b\u0915\u093e\u0907\u0928\u0947\u091f\u093f\u0915\u094d\u0938 \u0914\u0930 \u092b\u093c\u093e\u0930\u094d\u092e\u093e\u0915\u094b\u0921\u093e\u092f\u0928\u093e\u092e\u093f\u0915\u094d\u0938 \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0921\u093f\u091c\u093c\u093e\u0907\u0928 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948\u0964 \u0916\u0941\u0930\u093e\u0915 \u0939\u0930 \u091b\u0939 \u0938\u092a\u094d\u0924\u093e\u0939 \u092e\u0947\u0902 \u0926\u0940 \u091c\u093e\u090f\u0917\u0940, \u091c\u093f\u0938\u092e\u0947\u0902 \u0924\u0940\u0928 \u0938\u092e\u0942\u0939\u094b\u0902 \u092e\u0947\u0902 \u0928\u093f\u092f\u094b\u091c\u093f\u0924 \u0916\u0941\u0930\u093e\u0915 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0938\u0947 \u0932\u0947\u0915\u0930 15 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0924\u0915 \u0939\u094b\u0928\u0947 \u0915\u0940 \u0909\u092e\u094d\u092e\u0940\u0926 \u0939\u0948\u0964 \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u093e \u092d\u093e\u0917 B \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u092a\u094d\u0930\u092d\u093e\u0935\u0915\u093e\u0930\u093f\u0924\u093e \u0915\u0947 \u0932\u093f\u090f \u092d\u093e\u0917 A \u092e\u0947\u0902 \u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0907\u0937\u094d\u091f\u0924\u092e \u0916\u0941\u0930\u093e\u0915 \u0915\u093e \u0906\u0917\u0947 \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0947\u0917\u093e, \u091c\u093f\u0938\u092e\u0947\u0902 \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u092a\u0930\u093f\u0923\u093e\u092e \u0914\u0930 \u0930\u094b\u0917\u0940 \u0926\u094d\u0935\u093e\u0930\u093e \u0930\u093f\u092a\u094b\u0930\u094d\u091f \u0915\u0940 \u0917\u0908 \u091c\u0940\u0935\u0928 \u0915\u0940 \u0917\u0941\u0923\u0935\u0924\u094d\u0924\u093e \u0915\u0947 \u0909\u092a\u093e\u092f \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902\u0964 \u0905\u0927\u094d\u092f\u092f\u0928 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u0940 \u090f\u0915 \u0913\u092a\u0928 \u0932\u0947\u092c\u0932 \u090f\u0915\u094d\u0938\u091f\u0947\u0902\u0936\u0928 \u0905\u0927\u094d\u092f\u092f\u0928 (OLE) \u092e\u0947\u0902 \u092a\u094d\u0930\u0935\u0947\u0936 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u092a\u093e\u0924\u094d\u0930 \u0939\u094b \u0938\u0915\u0924\u0947 \u0939\u0948\u0902, \u091c\u093f\u0938\u092e\u0947\u0902 ENTR-601-45 \u0915\u0940 \u0938\u0941\u0930\u0915\u094d\u0937\u093e, \u092a\u094d\u0930\u092d\u093e\u0935\u0915\u093e\u0930\u093f\u0924\u093e \u0914\u0930 \u0938\u0939\u0928\u0940\u092f\u0924\u093e \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0932\u0902\u092c\u0947 \u0938\u092e\u092f \u0924\u0915 \u0915\u093f\u092f\u093e \u091c\u093e\u090f\u0917\u093e\u0964 \u0915\u0902\u092a\u0928\u0940 2025 \u0915\u0940 \u0924\u0940\u0938\u0930\u0940 \u0924\u093f\u092e\u093e\u0939\u0940 \u092e\u0947\u0902 ELEVATE-45-201 \u0906\u0930\u0902\u092d \u0915\u0930\u0928\u0947 \u0915\u0940 \u0926\u093f\u0936\u093e \u092e\u0947\u0902 \u0905\u0917\u094d\u0930\u0938\u0930 \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u092a\u0922\u093c\u0947\u0902<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/hi\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0921\u094d\u092f\u0942\u0936\u0947\u0928 \u0915\u0947 \u0932\u093f\u090f \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 (\u0938\u092d\u0940 \u0936\u094b\u0927\u094b\u0902 \u0915\u0940 \u0938\u0942\u091a\u0940)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Entrada Therapeutics, today announced it has received authorization from the Health Authorities and Ethics Committees of multiple countries under the European Union Clinical Trial Regulation (EU-CTR) to initiate ELEVATE-45-201, a Phase 1\/2 multiple ascending dose (MAD) clinical study of ENTR-601-45 in patients living with Duchenne muscular dystrophy (DMD) who are amenable to exon 45 skipping. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3881,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[320,91,321,234,317,318,319],"class_list":["post-3876","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-elevate-45-201","tag-ema","tag-entr-601-45","tag-entrada-therapeutics","tag-exon-45","tag-exon-45-skipping","tag-exon-45-skipping-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/3876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=3876"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/3876\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/3881"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=3876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=3876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=3876"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}