{"id":3720,"date":"2025-04-18T14:28:26","date_gmt":"2025-04-18T11:28:26","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3720"},"modified":"2025-04-18T14:39:11","modified_gmt":"2025-04-18T11:39:11","slug":"del-zota-explore44-provides-nearly-30-normal-dystrophin-production-in-patients-amenable-to-exon-44-skipping","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/del-zota-explore44-provides-nearly-30-normal-dystrophin-production-in-patients-amenable-to-exon-44-skipping\/","title":{"rendered":"\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e (EXPLORE44) \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0905\u0928\u0941\u0915\u0942\u0932 \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0932\u0917\u092d\u0917 30% \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u092a\u094d\u0930\u0926\u093e\u0928 \u0915\u0930\u0924\u093e \u0939\u0948"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e \u0915\u093e \u092e\u0942\u0932\u094d\u092f\u093e\u0902\u0915\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0905\u092c \u091a\u0930\u0923 1\/2 EXPLORE44 \u0905\u0927\u094d\u092f\u092f\u0928 (NCT05670730) \u0906\u092f\u094b\u091c\u093f\u0924 \u0915\u093f\u092f\u093e \u091c\u093e \u0930\u0939\u093e \u0939\u0948, \u091c\u093f\u0938\u0947 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0930\u0940\u0921\u093f\u0902\u0917 \u092b\u094d\u0930\u0947\u092e \u0915\u094b \u092c\u0939\u093e\u0932 \u0915\u0930\u0928\u0947 \u0914\u0930 \u090f\u0915 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0907\u0930\u093e\u0926\u0947 \u0938\u0947 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0925\u093e \u091c\u094b \u0915\u093e\u0930\u094d\u092f\u093e\u0924\u094d\u092e\u0915 \u0914\u0930 \u0906\u0902\u0924\u0930\u093f\u0915 \u0930\u0942\u092a \u0938\u0947 \u091b\u094b\u091f\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0921\u0932\u093e\u0938, \u091f\u0947\u0915\u094d\u0938\u093e\u0938 \u092e\u0947\u0902 16-19 \u092e\u093e\u0930\u094d\u091a \u0915\u094b \u0906\u092f\u094b\u091c\u093f\u0924 2025 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u090f\u0938\u094b\u0938\u093f\u090f\u0936\u0928 (\u090f\u092e\u0921\u0940\u090f) \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u0914\u0930 \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0938\u092e\u094d\u092e\u0947\u0932\u0928 \u092e\u0947\u0902 \u0907\u0938 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e \u0939\u093e\u0932 \u0939\u0940 \u092e\u0947\u0902 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924 \u0915\u093f\u090f \u0917\u090f, \u091c\u094b \u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915, \u0921\u092c\u0932-\u092c\u094d\u0932\u093e\u0907\u0902\u0921 \u0914\u0930 \u092a\u094d\u0932\u0947\u0938\u0940\u092c\u094b \u0915\u0947 \u0938\u093e\u0925 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0925\u093e\u0964 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937\u094b\u0902 \u0915\u0947 \u0906\u0927\u093e\u0930 \u092a\u0930, \u092f\u0939 \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0915\u093f \u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e \u092e\u0947\u0902 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093c\u093f\u0928 \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0914\u0930 \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u094b \u092c\u0922\u093c\u093e\u0935\u093e \u0926\u0947\u0928\u0947 \u0915\u0940 \u0915\u094d\u0937\u092e\u0924\u093e \u0939\u0948, \u091c\u092c\u0915\u093f \u0938\u093e\u0925 \u0939\u0940 \u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093f\u0928\u0947\u091c (\u0938\u0940\u0915\u0947) \u0915\u0940 \u0938\u0902\u0916\u094d\u092f\u093e \u0915\u094b \u0915\u092e \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u090f\u0935\u093f\u0921\u093f\u091f\u0940 \u0915\u0947 \u092e\u0941\u0916\u094d\u092f \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0905\u0927\u093f\u0915\u093e\u0930\u0940 \u0921\u0949. \u092e\u093e\u0907\u0915\u0932 \u092b\u093c\u094d\u0932\u0948\u0928\u0947\u0917\u0928 \u0915\u093e NeurologyLive \u0926\u094d\u0935\u093e\u0930\u093e \u0938\u093e\u0915\u094d\u0937\u093e\u0924\u094d\u0915\u093e\u0930 \u0932\u093f\u092f\u093e \u0917\u092f\u093e, \u091c\u093f\u0938\u092e\u0947\u0902 \u0921\u0947\u0932-\u091c\u093c\u094b\u091f\u093e \u0914\u0930 \u091a\u0930\u0923 1\/2 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e\u094b\u0902 \u092a\u0930 \u0905\u0927\u093f\u0915 \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u0938\u0947 \u091a\u0930\u094d\u091a\u093e \u0915\u0940 \u0917\u0908\u0964 \u0909\u0928\u094d\u0939\u094b\u0902\u0928\u0947 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0915\u094b \u0932\u0915\u094d\u0937\u093f\u0924 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u0940 \u0905\u0928\u0942\u0920\u0940 \u0921\u093f\u0932\u0940\u0935\u0930\u0940 \u0935\u093f\u0927\u093f \u0915\u0947 \u092c\u093e\u0930\u0947 \u092e\u0947\u0902 \u092c\u0924\u093e\u092f\u093e \u0914\u0930 \u092c\u0924\u093e\u092f\u093e \u0915\u093f \u092f\u0939 \u092a\u0939\u0932\u0947 \u0938\u0947 \u0938\u094d\u0935\u0940\u0915\u0943\u0924 \u0926\u0935\u093e\u0913\u0902 \u0914\u0930 \u091c\u093e\u0902\u091a \u0915\u0947 \u0924\u0939\u0924 \u0905\u0928\u094d\u092f \u0926\u0935\u093e\u0913\u0902 \u0938\u0947 \u0915\u093f\u0938 \u0924\u0930\u0939 \u092d\u093f\u0928\u094d\u0928 \u0939\u0948\u0964 \u092a\u0941\u0937\u094d\u091f\u093f\u0915\u0930\u0923 \u091a\u0930\u0923 3 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u090f\u0915 \u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u0914\u0930 \u0938\u0902\u092d\u093e\u0935\u093f\u0924 \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u093f\u0915\u094d\u0938 \u0932\u093e\u0907\u0938\u0947\u0902\u0938 \u0906\u0935\u0947\u0926\u0928 \u0926\u0935\u093e \u0915\u0947 \u0932\u093f\u090f \u092d\u0935\u093f\u0937\u094d\u092f \u0915\u0940 \u092f\u094b\u091c\u0928\u093e\u0913\u0902 \u092e\u0947\u0902 \u0938\u0947 \u0939\u0948\u0902, \u091c\u093f\u0938\u0915\u093e \u092b\u093c\u094d\u0932\u0948\u0928\u0947\u0917\u0928 \u0928\u0947 \u092a\u0942\u0930\u094d\u0935\u093e\u0935\u0932\u094b\u0915\u0928 \u092d\u0940 \u0926\u093f\u092f\u093e\u0964<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#phase-1-2-explore-44-trial-design\">\u091a\u0930\u0923 1\/2 EXPLORE 44 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0921\u093f\u091c\u093e\u0907\u0928<\/a><\/li><li><a href=\"#safety-and-tolerability\">\u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e<\/a><\/li><li><a href=\"#biomarker-outcomes\">\u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930 \u092a\u0930\u093f\u0923\u093e\u092e<\/a><\/li><li><a href=\"#creatine-kinase-ck-levels\">\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (\u0938\u0940\u0915\u0947) \u0938\u094d\u0924\u0930<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"phase-1-2-explore-44-trial-design\">\u091a\u0930\u0923 1\/2 EXPLORE 44 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0921\u093f\u091c\u093e\u0907\u0928<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915, \u092a\u094d\u0932\u0947\u0938\u0940\u092c\u094b-\u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924, \u0921\u092c\u0932-\u092c\u094d\u0932\u093e\u0907\u0902\u0921 \u092a\u0930\u0940\u0915\u094d\u0937\u0923<\/li>\n\n\n\n<li>\u0921\u0940\u090f\u092e\u0921\u094044 \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 24 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u0940 (\u0906\u092f\u0941 7-27 \u0935\u0930\u094d\u0937, \u091a\u0932\u0928\u0947-\u092b\u093f\u0930\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e \u0914\u0930 \u0917\u0948\u0930-\u091a\u0932\u0928\u0947 \u092e\u0947\u0902 \u0938\u0915\u094d\u0937\u092e)<\/li>\n\n\n\n<li>\u0909\u092a\u091a\u093e\u0930 \u0936\u093e\u0916\u093e\u090f\u0901: 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u092a\u094d\u0930\u0924\u094d\u092f\u0947\u0915 6 \u0938\u092a\u094d\u0924\u093e\u0939 \u092c\u0928\u093e\u092e 10 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u092a\u094d\u0930\u0924\u094d\u092f\u0947\u0915 8 \u0938\u092a\u094d\u0924\u093e\u0939 \u092c\u0928\u093e\u092e \u092a\u094d\u0932\u0947\u0938\u093f\u092c\u094b (3:1 \u092f\u093e\u0926\u0943\u091a\u094d\u091b\u093f\u0915\u0940\u0915\u0930\u0923)<\/li>\n\n\n\n<li>\u092e\u093e\u0902\u0938\u092a\u0947\u0936\u093f\u092f\u094b\u0902 \u0915\u0940 \u092c\u093e\u092f\u094b\u092a\u094d\u0938\u0940 \u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u092a\u0930 \u0914\u0930 \u0924\u0940\u0938\u0930\u0940 \u0916\u0941\u0930\u093e\u0915 \u0915\u0947 \u090f\u0915 \u092e\u0939\u0940\u0928\u0947 \u092c\u093e\u0926 \u0915\u0940 \u091c\u093e\u0924\u0940 \u0939\u0948<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"safety-and-tolerability\">\u0938\u0941\u0930\u0915\u094d\u0937\u093e \u0914\u0930 \u0938\u0939\u0928\u0936\u0940\u0932\u0924\u093e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0905\u0928\u0941\u0915\u0942\u0932 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u094b\u092b\u093c\u093e\u0907\u0932, \u0905\u0927\u093f\u0915\u093e\u0902\u0936 \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0918\u091f\u0928\u093e\u090f\u0901 \u0939\u0932\u094d\u0915\u0940 \u0938\u0947 \u092e\u0927\u094d\u092f\u092e<\/li>\n\n\n\n<li>\u0938\u092c\u0938\u0947 \u0906\u092e \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0918\u091f\u0928\u093e\u090f\u0901: \u092a\u094d\u0930\u0915\u094d\u0930\u093f\u092f\u093e\u0917\u0924 \u0926\u0930\u094d\u0926 \u0914\u0930 \u0938\u093f\u0930\u0926\u0930\u094d\u0926<\/li>\n\n\n\n<li>\u0926\u094b \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0928\u0947 \u0909\u092a\u091a\u093e\u0930 \u092c\u0902\u0926 \u0915\u0930 \u0926\u093f\u092f\u093e: 1 \u090f\u0928\u093e\u092b\u093e\u0907\u0932\u0948\u0915\u094d\u0938\u093f\u0938 \u0915\u0947 \u0915\u093e\u0930\u0923, 1 \u092e\u0927\u094d\u092f\u092e \u091c\u0932\u0938\u0947\u0915-\u0938\u0902\u092c\u0902\u0927\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0915\u0947 \u0915\u093e\u0930\u0923<\/li>\n\n\n\n<li>\u0915\u094b\u0908 \u0932\u0915\u094d\u0937\u0923\u093e\u0924\u094d\u092e\u0915 \u0939\u0940\u092e\u094b\u0917\u094d\u0932\u094b\u092c\u093f\u0928 \u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0928\u0939\u0940\u0902, \u0915\u094b\u0908 \u0939\u093e\u0907\u092a\u094b\u092e\u0948\u0917\u094d\u0928\u0947\u0938\u0940\u092e\u093f\u092f\u093e \u0928\u0939\u0940\u0902, \u0915\u094b\u0908 \u092e\u0943\u0924\u094d\u092f\u0941 \u0928\u0939\u0940\u0902<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"biomarker-outcomes\">\u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930 \u092a\u0930\u093f\u0923\u093e\u092e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0926\u094b\u0928\u094b\u0902 \u0916\u0941\u0930\u093e\u0915 \u0938\u092e\u0942\u0939\u094b\u0902 \u092e\u0947\u0902 \u0932\u0917\u093e\u0924\u093e\u0930 \u0914\u0930 \u0909\u091a\u094d\u091a PMO \u092e\u093e\u0902\u0938\u092a\u0947\u0936\u0940 \u0938\u093e\u0902\u0926\u094d\u0930\u0924\u093e<\/li>\n\n\n\n<li>\u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0932\u0902\u0918\u0928: 5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 37%, 10 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 43%<\/li>\n\n\n\n<li>\u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0915\u093e \u0909\u0924\u094d\u092a\u093e\u0926\u0928 \u0914\u0938\u0924\u0928 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0938\u094d\u0924\u0930 \u0938\u0947 \u0932\u0917\u092d\u0917 25% \u0924\u0915 \u092c\u0922\u093c \u0917\u092f\u093e<\/li>\n\n\n\n<li>\u0938\u092d\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0905\u0928\u0941\u0915\u0942\u0932 \u091c\u0940\u0928\u094b\u091f\u093e\u0907\u092a \u092e\u0947\u0902 58% \u0924\u0915 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0938\u094d\u0924\u0930 \u0926\u0947\u0916\u093e \u0917\u092f\u093e<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"creatine-kinase-ck-levels\">\u0915\u094d\u0930\u093f\u090f\u091f\u093f\u0928 \u0915\u093e\u0907\u0928\u0947\u091c (\u0938\u0940\u0915\u0947) \u0938\u094d\u0924\u0930<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0909\u092a\u091a\u093e\u0930\u093f\u0924 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u092e\u0947\u0902 \u0938\u0940.\u0915\u0947. \u0915\u093e \u0938\u094d\u0924\u0930 \u0932\u0917\u093e\u0924\u093e\u0930 \u0915\u092e \u0939\u094b\u0915\u0930 \u0932\u0917\u092d\u0917 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0939\u094b \u0917\u092f\u093e<\/li>\n\n\n\n<li>5 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 70-140 \u0926\u093f\u0928 \u0938\u0947 \u0932\u0947\u0915\u0930 10 \u092e\u093f\u0932\u0940\u0917\u094d\u0930\u093e\u092e\/\u0915\u093f\u0917\u094d\u0930\u093e \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 84-140 \u0926\u093f\u0928 \u0924\u0915 \u0938\u0940\u0915\u0947 \u092e\u0947\u0902 \u0915\u092e\u0940 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0915\u0940 \u090a\u092a\u0930\u0940 \u0938\u0940\u092e\u093e \u0915\u0947 \u0915\u0930\u0940\u092c \u092c\u0928\u0940 \u0930\u0939\u0940<\/li>\n\n\n\n<li>\u0906\u0927\u093e\u0930 \u0930\u0947\u0916\u093e \u0915\u0940 \u0924\u0941\u0932\u0928\u093e \u092e\u0947\u0902 \u0938\u0940.\u0915\u0947. \u0938\u094d\u0924\u0930 \u092e\u0947\u0902 80% \u0938\u0947 \u0905\u0927\u093f\u0915 \u0915\u092e\u0940<\/li>\n\n\n\n<li>\u0913\u092a\u0928-\u0932\u0947\u092c\u0932 \u0935\u093f\u0938\u094d\u0924\u093e\u0930 \u092e\u0947\u0902 1 \u0935\u0930\u094d\u0937 \u0924\u0915 \u0915\u0940 \u0915\u091f\u094c\u0924\u0940 \u091c\u093e\u0930\u0940 \u0930\u0939\u0947\u0917\u0940<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902: <a href=\"https:\/\/dmdwarrior.com\/hi\/next-generation-exon-skipping-therapies-for-duchenne-muscular-dystrophy\/\">\u0905\u0917\u0932\u0940 \u092a\u0940\u0922\u093c\u0940 \u0915\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>A phase 1\/2 EXPLORE44 study (NCT05670730) is now being conducted to evaluate Del-zota, which was developed with the intention of restoring the dystrophin reading frame and producing a dystrophin protein that is functional and internally truncated. At the 2025 Muscular Dystrophy Association (MDA) Clinical &amp; Scientific Conference, which took place in Dallas, Texas, from March [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3722,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282],"tags":[126,298,141,127,246,299],"class_list":["post-3720","post","type-post","status-publish","format-standard","has-post-thumbnail","category-editorials","tag-avidity-biosciences","tag-del-zota","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-explore44"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/3720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=3720"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/3720\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/3722"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=3720"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=3720"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=3720"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}