{"id":2380,"date":"2025-01-10T11:32:46","date_gmt":"2025-01-10T08:32:46","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2380"},"modified":"2025-03-27T16:49:38","modified_gmt":"2025-03-27T13:49:38","slug":"nippon-shinyaku-releases-first-clinical-trial-first-in-human-of-brogidirsen-ns-089-ncnp-02-for-the-treatment-of-duchenne","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/hi\/nippon-shinyaku-releases-first-clinical-trial-first-in-human-of-brogidirsen-ns-089-ncnp-02-for-the-treatment-of-duchenne\/","title":{"rendered":"\u0928\u093f\u092a\u094d\u092a\u0949\u0928 \u0936\u093f\u0928\u094d\u092f\u093e\u0915\u0942 \u0928\u0947 \u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u0938\u0947\u0928 NS-089\/NCNP-02 \u0915\u093e \u092a\u0939\u0932\u093e \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 (\u092e\u093e\u0928\u0935 \u092e\u0947\u0902 \u092a\u0939\u0932\u093e) \u091c\u093e\u0930\u0940 \u0915\u093f\u092f\u093e"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0928\u0947\u0936\u0928\u0932 \u0938\u0947\u0902\u091f\u0930 \u0911\u092b \u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u0940 \u090f\u0902\u0921 \u0938\u093e\u0907\u0915\u093f\u092f\u093e\u091f\u094d\u0930\u0940 \u0928\u0947 \u0938\u0947\u0932 \u0930\u093f\u092a\u094b\u0930\u094d\u091f\u094d\u0938 \u092e\u0947\u0921\u093f\u0938\u093f\u0928 \u092e\u0947\u0902 \u090f\u0915 \u0936\u094b\u0927 \u092a\u0924\u094d\u0930 \u092a\u094d\u0930\u0915\u093e\u0936\u093f\u0924 \u0915\u0930\u0928\u0947 \u0915\u0940 \u0918\u094b\u0937\u0923\u093e \u0915\u0940 \u0939\u0948, \u091c\u093f\u0938\u092e\u0947\u0902 \u090f\u0928\u090f\u0938-089\/\u090f\u0928\u0938\u0940\u090f\u0928\u092a\u0940-02 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u0905\u0928\u094d\u0935\u0947\u0937\u0915 \u0926\u094d\u0935\u093e\u0930\u093e \u0936\u0941\u0930\u0942 \u0915\u093f\u090f \u0917\u090f \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e\u094b\u0902 \u0915\u093e \u0935\u093f\u0935\u0930\u0923 \u0926\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u091c\u093f\u0938\u0947 &quot;\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u0938\u0947\u0928&quot; \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902 \u091c\u093e\u0928\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0921\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 (\u0921\u0940\u090f\u092e\u0921\u0940) \u0915\u0947 \u0932\u093f\u090f \u092f\u0939 \u0905\u092d\u093f\u0928\u0935 \u0909\u092a\u091a\u093e\u0930, \u0928\u093f\u092a\u094d\u092a\u0949\u0928 \u0936\u093f\u0928\u094d\u092f\u093e\u0915\u0942 \u0915\u0902\u092a\u0928\u0940 \u0932\u093f\u092e\u093f\u091f\u0947\u0921 \u0915\u0947 \u0938\u093e\u0925 \u0938\u0902\u092f\u0941\u0915\u094d\u0924 \u0930\u0942\u092a \u0938\u0947 \u0935\u093f\u0915\u0938\u093f\u0924 \u0915\u093f\u092f\u093e \u0917\u092f\u093e \u0939\u0948, \u091c\u094b \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940 \u092e\u0947\u0902 \u090f\u0915 \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u092a\u094d\u0930\u0917\u0924\u093f \u0915\u093e \u092a\u094d\u0930\u0924\u093f\u0928\u093f\u0927\u093f\u0924\u094d\u0935 \u0915\u0930\u0924\u093e \u0939\u0948\u0964<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u0935\u093f\u0937\u092f\u0938\u0942\u091a\u0940<\/h2><nav><ul><li><a href=\"#key-findings-from-brogidirsen-include\">Brogidirsen \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e<\/a><\/li><li><a href=\"#what-is-brogidirsen\">\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u094d\u0938\u0947\u0928 \u0915\u094d\u092f\u093e \u0939\u0948?<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"key-findings-from-brogidirsen-include\">Brogidirsen \u0915\u094d\u0932\u093f\u0928\u093f\u0915\u0932 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0947 \u092a\u0930\u093f\u0923\u093e\u092e<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u0938\u0928 \u0928\u0947 \u0921\u0940.\u090f\u092e.\u0921\u0940. \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u092e\u0947\u0902 \u0916\u0941\u0930\u093e\u0915 \u092a\u0930 \u0928\u093f\u0930\u094d\u092d\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u092c\u0939\u093e\u0932\u0940 \u0915\u094b \u0926\u0930\u094d\u0936\u093e\u092f\u093e\u0964<\/li>\n\n\n\n<li>\u0909\u091a\u094d\u091a \u0916\u0941\u0930\u093e\u0915 \u0935\u093e\u0932\u0947 \u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u0938\u0947\u0928 \u0928\u0947 \u0921\u0940.\u090f\u092e.\u0921\u0940. \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u0938\u094d\u0924\u0930 \u0915\u0947 24.47% \u0924\u0915 \u092a\u0939\u0941\u0902\u091a \u0917\u092f\u093e\u0964<\/li>\n\n\n\n<li>\u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0928\u0947 \u0938\u094d\u0925\u093f\u0930 \u092f\u093e \u092c\u0947\u0939\u0924\u0930 \u092e\u094b\u091f\u0930 \u0915\u093e\u0930\u094d\u092f \u0915\u0947 \u0938\u093e\u0925 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0932\u093e\u092d \u0914\u0930 \u0905\u0928\u0941\u0915\u0942\u0932 \u0938\u0941\u0930\u0915\u094d\u0937\u093e \u092a\u094d\u0930\u094b\u092b\u093c\u093e\u0907\u0932 \u0915\u094b \u092a\u094d\u0930\u0926\u0930\u094d\u0936\u093f\u0924 \u0915\u093f\u092f\u093e, \u091c\u093f\u0938\u092e\u0947\u0902 \u0915\u094b\u0908 \u0917\u0902\u092d\u0940\u0930 \u092a\u094d\u0930\u0924\u093f\u0915\u0942\u0932 \u0918\u091f\u0928\u093e \u0928\u0939\u0940\u0902 \u0939\u0941\u0908\u0964<\/li>\n\n\n\n<li>\u0921\u0940\u090f\u092e\u0921\u0940 \u0915\u0947 \u0932\u093f\u090f \u0938\u0940\u0930\u092e \u092c\u093e\u092f\u094b\u092e\u093e\u0930\u094d\u0915\u0930\u094d\u0938 \u0915\u0940 \u092a\u0939\u091a\u093e\u0928 \u0915\u0940 \u0917\u0908, \u091c\u093f\u0928\u092e\u0947\u0902 PADI2, TTN, MYOM2 \u0914\u0930 MYLPF \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902\u0964<\/li>\n\n\n\n<li>\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u094d\u0938\u0947\u0928 \u0928\u0947 \u0921\u0940\u090f\u092e\u0921\u0940 \u092e\u0942\u0924\u094d\u0930-\u0935\u094d\u092f\u0941\u0924\u094d\u092a\u0928\u094d\u0928 \u0915\u094b\u0936\u093f\u0915\u093e\u0913\u0902 \u092e\u0947\u0902 \u0909\u091a\u094d\u091a \u0926\u0915\u094d\u0937\u0924\u093e \u0926\u093f\u0916\u093e\u0908, \u091c\u093f\u0938\u0938\u0947 \u092e\u093e\u0928\u0935 \u092a\u0930\u0940\u0915\u094d\u0937\u0923\u094b\u0902 \u0915\u094b \u0938\u092e\u0930\u094d\u0925\u0928 \u092e\u093f\u0932\u093e\u0964<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-brogidirsen\">\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u094d\u0938\u0947\u0928 \u0915\u094d\u092f\u093e \u0939\u0948?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u092c\u094d\u0930\u094b\u0917\u093f\u0921\u093f\u0930\u094d\u0938\u0947\u0928 (NS-089\/NCNP-02) \u090f\u0915 \u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u0915 \u090f\u0938\u093f\u0921 \u0926\u0935\u093e \u0939\u0948, \u091c\u093f\u0938\u0915\u0940 \u0916\u094b\u091c \u0928\u093f\u092a\u094d\u092a\u0949\u0928 \u0936\u093f\u0928\u094d\u092f\u093e\u0915\u0942 \u0914\u0930 NCNP \u0926\u094d\u0935\u093e\u0930\u093e \u0915\u0940 \u0917\u0908 \u0939\u0948, \u0914\u0930 \u092f\u0939 \u0909\u092e\u094d\u092e\u0940\u0926 \u0915\u0940 \u091c\u093e\u0924\u0940 \u0939\u0948 \u0915\u093f \u092f\u0939 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0915\u0947 \u0932\u093f\u090f \u0909\u0924\u094d\u0924\u0930\u0926\u093e\u092f\u0940 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u094b\u092b\u093f\u0928 \u091c\u0940\u0928 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0935\u093e\u0932\u0947 DMD \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0926\u0935\u093e \u0939\u094b\u0917\u0940\u0964<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0914\u0930 \u0905\u0927\u093f\u0915 \u091c\u093e\u0928\u0947\u0902:<\/strong> <a href=\"https:\/\/dmdwarrior.com\/hi\/upcoming-exon-44-skipping-therapies-for-dmd\/\" data-type=\"post\" data-id=\"2811\">\u0921\u094d\u092f\u0942\u091a\u0947\u0928 \u092e\u0938\u094d\u0915\u0941\u0932\u0930 \u0921\u093f\u0938\u094d\u091f\u094d\u0930\u0949\u092b\u0940 \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0932\u093f\u090f \u0906\u0917\u093e\u092e\u0940 \u090f\u0915\u094d\u0938\u0949\u0928 44 \u0938\u094d\u0915\u093f\u092a\u093f\u0902\u0917 \u0925\u0947\u0930\u0947\u092a\u0940<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The National Center of Neurology and Psychiatry is announced the publication of a research paper in Cell Reports Medicine detailing the results of an investigator-initiated trial for NS-089\/NCNP-02, known as &#8220;brogidirsen.&#8221; This innovative treatment for Duchenne muscular dystrophy (DMD), jointly developed with Nippon Shinyaku Co., Ltd., represents a significant advancement in exon 44 skipping therapy. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2383,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[138,137,141,127,77,142,136,139,140],"class_list":["post-2380","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-brogidirsen","tag-clinical-trial","tag-exon-44","tag-exon-44-skipping","tag-exon-skipping","tag-japan","tag-nippon-shinyaku","tag-ns-089","tag-ns-089-ncnp-02"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/2380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/comments?post=2380"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/posts\/2380\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media\/2383"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/media?parent=2380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/categories?post=2380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/hi\/wp-json\/wp\/v2\/tags?post=2380"}],"curies":[{"name":"\u0921\u092c\u094d\u0932\u094d\u092f\u0942\u092a\u0940","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}