{"id":5164,"date":"2025-11-17T16:46:57","date_gmt":"2025-11-17T13:46:57","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5164"},"modified":"2025-11-17T17:27:48","modified_gmt":"2025-11-17T14:27:48","slug":"ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/fr\/ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye\/","title":{"rendered":"Ali Taghizadeh annonce une th\u00e9rapie par ARNm ANKA pour la DMD, actuellement en essai clinique en Turquie."},"content":{"rendered":"<p class=\"wp-block-paragraph\">Le pharmacologue turc, le professeur associ\u00e9 Dr Ali Taghizadeh, a annonc\u00e9 en anglais \u00e0 ses abonn\u00e9s \u00e0 l&#039;\u00e9tranger la th\u00e9rapie \u00e0 ARNm sur laquelle il travaille pour la dystrophie musculaire de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Le professeur agr\u00e9g\u00e9 Dr Ali Taghizadeh a partag\u00e9 sur son compte Instagram une vid\u00e9o d&#039;information en anglais concernant DMD ANKA, la th\u00e9rapie \u00e0 ARNm qu&#039;il a d\u00e9velopp\u00e9e pour la dystrophie musculaire de Duchenne. <strong>Apprendre encore plus<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/fr\/mrna-duchenne-muscular-dystrophy-dmd-treatment\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u00c9tudes de l&#039;ARNm dans le traitement de la DMD\u00a0: futurs candidats th\u00e9rapeutiques<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Que signifie ANKA ?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ANKA est une cr\u00e9ature mythologique qui signifie \u00ab oiseau \u00bb en turc et est connue sous le nom de Ph\u00e9nix en anglais.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Introduction du DMD ANKA<\/h2>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-captioned data-instgrm-permalink=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; border:0; border-radius:3px; box-shadow:0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width:540px; min-width:326px; padding:0; width:99.375%; width:-webkit-calc(100% - 2px); width:calc(100% - 2px);\"><div style=\"padding:16px;\"> <a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" background:#FFFFFF; line-height:0; padding:0 0; text-align:center; text-decoration:none; width:100%;\" target=\"_blank\" rel=\"noopener\"> <div style=\" display: flex; flex-direction: row; align-items: center;\"> <div style=\"background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">Je vous conseille d&#039;Instagram<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">DMD Hastal\u0131\u011f\u0131, Ali Taghizadeh (@alitgzd)&#039;in payla\u015ft\u0131\u011f\u0131 bir g\u00f6nderi<\/a><\/p><\/div><\/blockquote>\n<script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Voici le texte int\u00e9gral de la vid\u00e9o\u00a0:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Bonjour \u00e0 tous, c&#039;est Ali Taghizadeh.<br>Je viens de l&#039;universit\u00e9 Bilecik \u015eeyh Edebali.<br>Je suis professeur associ\u00e9 en pharmacologie m\u00e9dicale.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Je souhaite pr\u00e9senter notre DMD ANKA aux \u00e9trangers r\u00e9sidant hors de Turquie.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nous pouvons \u00e9valuer DMD ANKA selon trois th\u00e8mes diff\u00e9rents.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>La premi\u00e8re est la s\u00e9quence d&#039;ARNm que nous avons utilis\u00e9e dans le DMD ANKA.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Comme vous le savez, la dystrophine poss\u00e8de la plus grande prot\u00e9ine de l&#039;organisme, associ\u00e9e \u00e0 la plus grande s\u00e9quence d&#039;ARNm.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Il s&#039;agit d&#039;une mol\u00e9cule de phosphate d&#039;environ quinze mille atomes, et sa stabilisation est tr\u00e8s complexe, ce qui repr\u00e9sente un d\u00e9fi majeur pour les scientifiques. Nous sommes d\u00e9sormais capables de la produire et de la stabiliser sans aucun produit chimique ni substance dangereuse.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Deuxi\u00e8me \u00e9tape : nous voulons DMD ANKA impliqu\u00e9 dans les cycles cellulaires ou la physiologie cellulaire.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cela signifie que lorsque nous administrons du DMD ANKA au patient, nous voulons que le DMD ANKA passe par le sang et atteigne les cellules, puis qu&#039;il soit tri\u00e9 physiologiquement pour que la cellule pense : \u00ab C&#039;est mon produit, je l&#039;ai produit \u00e0 partir de notre ADN, et cet ARNm est traduit en prot\u00e9ine par le syst\u00e8me r\u00e9ticulaire endoplasmique (Ras), puis localis\u00e9 dans les cellules. \u00bb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Notre troisi\u00e8me \u00e9tape consiste \u00e0 permettre aux cellules de commencer \u00e0 se r\u00e9tablir et \u00e0 se r\u00e9g\u00e9n\u00e9rer d\u00e8s les premi\u00e8res heures, gr\u00e2ce \u00e0 l&#039;implication de notre ARNm dans la physiologie cellulaire.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C&#039;est tr\u00e8s important car, lorsque nous voulons franchir une \u00e9tape avec une dystrophine fonctionnelle, nous devons comprendre qu&#039;il s&#039;agit de mon ARNm, que je vais le traduire en prot\u00e9ine et l&#039;envoyer \u00e0 la membrane pour qu&#039;il puisse accomplir sa fonction, permettant ainsi \u00e0 la cellule de le traiter.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C&#039;est tr\u00e8s important car la fibrose et tous les processus inflammatoires sont le fait des cellules de l&#039;organisme.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lorsque nous voulons mettre fin \u00e0 la fibrose et \u00e0 l&#039;inflammation, nous devons le faire en jouant avec les cellules.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cela signifie qu&#039;apr\u00e8s avoir localis\u00e9 la dystrophine dans la membrane et s&#039;\u00eatre fix\u00e9e aux dystroglycanes, les sarcoglycanes, apr\u00e8s inspection et action de l&#039;actine alpha, les neurones aff\u00e9rents entre le muscle et le cerveau sont reconstruits, r\u00e9cup\u00e9r\u00e9s, r\u00e9g\u00e9n\u00e9r\u00e9s et, par ce processus, l&#039;\u00e9limination de la fibrose commence.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">C&#039;est important pour nous car le DMD ANKA peut \u00eatre utilis\u00e9 chez l&#039;adulte et chez l&#039;enfant atteint de dystrophie musculaire de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Suivre cette page<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/fr\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tous les essais cliniques pour la dystrophie musculaire de Duchenne<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Turkish pharmacologist Assoc. Prof. Dr. Ali Taghizadeh announced in English to his followers abroad the mRNA therapy he is working on for Duchenne Muscular Dystrophy. Associate Professor Dr. Ali Taghizadeh shared an English-language information video on his Instagram account about DMD ANKA, the mRNA therapy he developed for Duchenne muscular dystrophy. Learn More: mRNA Studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5165,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[345,333,359,202,455],"class_list":["post-5164","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-ali-taghizadeh","tag-dmd-anka","tag-full-length-dystrophin","tag-mrna","tag-mrna-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/5164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/comments?post=5164"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/5164\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media\/5165"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media?parent=5164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/categories?post=5164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/tags?post=5164"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}