{"id":3823,"date":"2025-05-07T15:43:13","date_gmt":"2025-05-07T12:43:13","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3823"},"modified":"2025-05-07T15:43:14","modified_gmt":"2025-05-07T12:43:14","slug":"sonothera-ultrasound-mediated-delivery-method-can-deliver-full-length-dystrophin-to-cells","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/fr\/sonothera-ultrasound-mediated-delivery-method-can-deliver-full-length-dystrophin-to-cells\/","title":{"rendered":"La m\u00e9thode d&#039;administration par ultrasons SonoThera peut d\u00e9livrer la dystrophine compl\u00e8te aux cellules"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Les r\u00e9sultats de l&#039;\u00e9tude, actuellement en cours de d\u00e9veloppement pour le traitement de la dystrophie musculaire de Duchenne (DMD) du SonoThera, d\u00e9montrent la capacit\u00e9 de la technologie d&#039;administration par ultrasons \u00e0 administrer des m\u00e9dicaments g\u00e9n\u00e9tiques. <strong>Cette technologie permet l\u2019expression compl\u00e8te de la prot\u00e9ine dystrophine dans les muscles squelettiques, cardiaques et diaphragmatiques dans les mod\u00e8les de souris et de primates non humains (NHP).<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SonoThera, une soci\u00e9t\u00e9 de biotechnologie d\u00e9di\u00e9e au traitement de la cause profonde des maladies humaines en d\u00e9veloppant la prochaine g\u00e9n\u00e9ration de m\u00e9dicaments g\u00e9n\u00e9tiques, a annonc\u00e9 aujourd&#039;hui qu&#039;elle pr\u00e9senterait de nouvelles donn\u00e9es lors de la 28e r\u00e9union annuelle de l&#039;American Society of Gene and Cell Therapy (ASGCT) qui se tiendra du 13 au 17 mai \u00e0 la Nouvelle-Orl\u00e9ans, en Louisiane.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00ab Nous sommes heureux de pr\u00e9senter de nouvelles donn\u00e9es \u00e0 l&#039;ASGCT soulignant le potentiel de l&#039;administration par ultrasons pour r\u00e9soudre les principaux d\u00e9fis de la m\u00e9decine g\u00e9n\u00e9tique \u00bb, a d\u00e9clar\u00e9 Kenneth Greenberg, PhD, PDG de SonoThera. <strong>\u00ab Ces donn\u00e9es continuent de d\u00e9montrer nos capacit\u00e9s uniques, notamment l&#039;expression cibl\u00e9e de la dystrophine humaine sur toute sa longueur dans le muscle et la fourniture de charges g\u00e9n\u00e9tiques surdimensionn\u00e9es de mani\u00e8re durable, s\u00fbre, redosable et non invasive.<\/strong> Nous sommes impatients de partager nos derni\u00e8res donn\u00e9es lors de la r\u00e9union annuelle de cette ann\u00e9e. \u00bb<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Apprendre encore plus: <a href=\"https:\/\/dmdwarrior.com\/fr\/sonothera-presents-new-data-of-genetic-medicine-using-targeted-ultrasound-mediated-delivery-umd-in-treating-duchenne-muscular-dystrophy\/\" target=\"_blank\" rel=\"noreferrer noopener\">Transmission par ultrasons (AUM)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>The findings of the study, which are currently being developed for SonoThera&#8217;s Duchenne Muscular Dystrophy (DMD) treatment, demonstrate the capability of Ultrasound-Mediated Delivery technology to deliver genetic drugs. This technology enables full-length dystrophin protein expression in skeletal, cardiac, and diaphragm muscles in mouse and non-human primate (NHP) models. SonoThera, a biotechnology company dedicated to treating [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3824,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[366,359,367,285,286],"class_list":["post-3823","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-asgct-2025","tag-full-length-dystrophin","tag-kenneth-greenberg","tag-sonothera","tag-ultrasound-mediated-delivery"],"subtitle":"Les donn\u00e9es de l'\u00e9tude, actuellement en cours de d\u00e9veloppement pour le traitement DMD de SonoThera, d\u00e9montrent la capacit\u00e9 de la technologie d'administration par ultrasons \u00e0 administrer des m\u00e9dicaments g\u00e9n\u00e9tiques, permettant l'expression compl\u00e8te de la prot\u00e9ine dystrophine dans les muscles squelettiques, cardiaques et diaphragmatiques chez la souris et les mod\u00e8les de primates non humains (NHP).","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/3823","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/comments?post=3823"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/3823\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media\/3824"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media?parent=3823"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/categories?post=3823"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/tags?post=3823"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}