{"id":2162,"date":"2025-01-01T12:34:10","date_gmt":"2025-01-01T09:34:10","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2162"},"modified":"2025-01-01T12:34:11","modified_gmt":"2025-01-01T09:34:11","slug":"new-research-c-terminal-ct-domain-between-dystrophin-and-dystrobrevin","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/fr\/new-research-c-terminal-ct-domain-between-dystrophin-and-dystrobrevin\/","title":{"rendered":"De nouvelles recherches sur les interactions prot\u00e9iques de la dystrophie musculaire de Duchenne conduisent \u00e0 des th\u00e9rapies plus cibl\u00e9es"},"content":{"rendered":"<p class=\"wp-block-paragraph\">Une d\u00e9couverte pionni\u00e8re a montr\u00e9 les relations complexes entre la dystrophine, une prot\u00e9ine de stabilit\u00e9 musculaire, et sa prot\u00e9ine compagnon, la dystrobr\u00e9vine, ouvrant de nouvelles voies pour l\u2019\u00e9tude et le traitement de la dystrophie musculaire de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Les chercheurs d\u00e9crivent la r\u00e9gion cryptique C-terminale (CT) de la dystrophine et son r\u00f4le dans le maintien des membranes cellulaires \u00e0 travers les tissus dans le Journal of Biological Chemistry de d\u00e9cembre.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00ab Cette recherche met en \u00e9vidence la dynamique complexe des interactions entre la dystrophine et la dystrobr\u00e9vine, fournissant des informations cruciales qui pourraient \u00e9clairer le d\u00e9veloppement futur de traitements \u00bb, a d\u00e9clar\u00e9 l\u2019auteur principal de l\u2019\u00e9tude, Krishna Mallela, professeur \u00e0 la facult\u00e9 de pharmacie et des sciences pharmaceutiques de l\u2019universit\u00e9 du Colorado Skaggs. Notre compr\u00e9hension du fonctionnement de ces prot\u00e9ines dans divers tissus nous rapproche un peu plus de la d\u00e9couverte de traitements contre la DMD qui ciblent les causes profondes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/news.cuanschutz.edu\/news-stories\/new-study-uncovers-key-insights-into-protein-interactions-in-duchenne-muscular-dystrophy-paving-way-for-more-targeted-therapies\" target=\"_blank\" rel=\"noreferrer noopener\">En savoir plus<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(24)02504-3\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">Lien de recherche<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>A pioneering discovery has shown the complicated relationships between dystrophin, a muscle stability protein, and its companion protein, dystrobrevin, opening new avenues for studying and treating Duchenne Muscular Dystrophy. Researchers describe dystrophin cryptic C-terminal (CT) region and its role in maintaining cellular membranes across tissues in the December Journal of Biological Chemistry. \u201cThis research highlights [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2166,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[66,74,73,61],"class_list":["post-2162","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-duchenne-muscular-dystrophy","tag-dystrobrevin","tag-dystrophin","tag-gene-therapy"],"subtitle":"Les r\u00e9sultats d\u2019une \u00e9tude expliquent comment la dystrophine fonctionne au niveau mol\u00e9culaire, r\u00e9v\u00e9lant ainsi comment des m\u00e9dicaments contre la dystrophie musculaire peuvent \u00eatre d\u00e9velopp\u00e9s.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/2162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/comments?post=2162"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/posts\/2162\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media\/2166"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/media?parent=2162"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/categories?post=2162"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/fr\/wp-json\/wp\/v2\/tags?post=2162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}