{"id":5164,"date":"2025-11-17T16:46:57","date_gmt":"2025-11-17T13:46:57","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5164"},"modified":"2025-11-17T17:27:48","modified_gmt":"2025-11-17T14:27:48","slug":"ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/es\/ali-taghizadeh-announces-dmd-anka-mrna-therapy-currently-in-clinical-trial-in-turkiye\/","title":{"rendered":"Ali Taghizadeh anuncia la terapia de ARNm ANKA para la DMD, actualmente en ensayo cl\u00ednico en Turqu\u00eda."},"content":{"rendered":"<p class=\"wp-block-paragraph\">El farmac\u00f3logo turco, profesor asociado Dr. Ali Taghizadeh, anunci\u00f3 en ingl\u00e9s a sus seguidores en el extranjero la terapia de ARNm en la que est\u00e1 trabajando para la distrofia muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El profesor asociado Dr. Ali Taghizadeh comparti\u00f3 en su cuenta de Instagram un v\u00eddeo informativo en ingl\u00e9s sobre DMD ANKA, la terapia de ARNm que desarroll\u00f3 para la distrofia muscular de Duchenne. <strong>M\u00e1s informaci\u00f3n<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/es\/mrna-duchenne-muscular-dystrophy-dmd-treatment\/\" target=\"_blank\" rel=\"noreferrer noopener\">Estudios de ARNm en el tratamiento de la DMD: Futuros candidatos terap\u00e9uticos<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00bfQu\u00e9 significa ANKA?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">ANKA es una criatura mitol\u00f3gica que significa Ave Anka en turco y se conoce como F\u00e9nix en ingl\u00e9s.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Introducci\u00f3n de DMD ANKA<\/h2>\n\n\n\n<blockquote class=\"instagram-media\" data-instgrm-captioned data-instgrm-permalink=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\" style=\" background:#FFF; 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flex-grow: 0; height: 14px; width: 60px;\"><\/div><\/div><\/div><div style=\"padding: 19% 0;\"><\/div> <div style=\"display:block; height:50px; margin:0 auto 12px; width:50px;\"><svg width=\"50px\" height=\"50px\" viewbox=\"0 0 60 60\" version=\"1.1\" xmlns=\"https:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"https:\/\/www.w3.org\/1999\/xlink\"><g stroke=\"none\" stroke-width=\"1\" fill=\"none\" fill-rule=\"evenodd\"><g transform=\"translate(-511.000000, -20.000000)\" fill=\"#000000\"><g><path d=\"M556.869,30.41 C554.814,30.41 553.148,32.076 553.148,34.131 C553.148,36.186 554.814,37.852 556.869,37.852 C558.924,37.852 560.59,36.186 560.59,34.131 C560.59,32.076 558.924,30.41 556.869,30.41 M541,60.657 C535.114,60.657 530.342,55.887 530.342,50 C530.342,44.114 535.114,39.342 541,39.342 C546.887,39.342 551.658,44.114 551.658,50 C551.658,55.887 546.887,60.657 541,60.657 M541,33.886 C532.1,33.886 524.886,41.1 524.886,50 C524.886,58.899 532.1,66.113 541,66.113 C549.9,66.113 557.115,58.899 557.115,50 C557.115,41.1 549.9,33.886 541,33.886 M565.378,62.101 C565.244,65.022 564.756,66.606 564.346,67.663 C563.803,69.06 563.154,70.057 562.106,71.106 C561.058,72.155 560.06,72.803 558.662,73.347 C557.607,73.757 556.021,74.244 553.102,74.378 C549.944,74.521 548.997,74.552 541,74.552 C533.003,74.552 532.056,74.521 528.898,74.378 C525.979,74.244 524.393,73.757 523.338,73.347 C521.94,72.803 520.942,72.155 519.894,71.106 C518.846,70.057 518.197,69.06 517.654,67.663 C517.244,66.606 516.755,65.022 516.623,62.101 C516.479,58.943 516.448,57.996 516.448,50 C516.448,42.003 516.479,41.056 516.623,37.899 C516.755,34.978 517.244,33.391 517.654,32.338 C518.197,30.938 518.846,29.942 519.894,28.894 C520.942,27.846 521.94,27.196 523.338,26.654 C524.393,26.244 525.979,25.756 528.898,25.623 C532.057,25.479 533.004,25.448 541,25.448 C548.997,25.448 549.943,25.479 553.102,25.623 C556.021,25.756 557.607,26.244 558.662,26.654 C560.06,27.196 561.058,27.846 562.106,28.894 C563.154,29.942 563.803,30.938 564.346,32.338 C564.756,33.391 565.244,34.978 565.378,37.899 C565.522,41.056 565.552,42.003 565.552,50 C565.552,57.996 565.522,58.943 565.378,62.101 M570.82,37.631 C570.674,34.438 570.167,32.258 569.425,30.349 C568.659,28.377 567.633,26.702 565.965,25.035 C564.297,23.368 562.623,22.342 560.652,21.575 C558.743,20.834 556.562,20.326 553.369,20.18 C550.169,20.033 549.148,20 541,20 C532.853,20 531.831,20.033 528.631,20.18 C525.438,20.326 523.257,20.834 521.349,21.575 C519.376,22.342 517.703,23.368 516.035,25.035 C514.368,26.702 513.342,28.377 512.574,30.349 C511.834,32.258 511.326,34.438 511.181,37.631 C511.035,40.831 511,41.851 511,50 C511,58.147 511.035,59.17 511.181,62.369 C511.326,65.562 511.834,67.743 512.574,69.651 C513.342,71.625 514.368,73.296 516.035,74.965 C517.703,76.634 519.376,77.658 521.349,78.425 C523.257,79.167 525.438,79.673 528.631,79.82 C531.831,79.965 532.853,80.001 541,80.001 C549.148,80.001 550.169,79.965 553.369,79.82 C556.562,79.673 558.743,79.167 560.652,78.425 C562.623,77.658 564.297,76.634 565.965,74.965 C567.633,73.296 568.659,71.625 569.425,69.651 C570.167,67.743 570.674,65.562 570.82,62.369 C570.966,59.17 571,58.147 571,50 C571,41.851 570.966,40.831 570.82,37.631\"><\/path><\/g><\/g><\/g><\/svg><\/div><div style=\"padding-top: 8px;\"> <div style=\" color:#3897f0; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:550; line-height:18px;\">Bu g\u00f6nderiyi Instagram&#039;da g\u00f6r<\/div><\/div><div style=\"padding: 12.5% 0;\"><\/div> <div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\"><div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div> <div style=\"background-color: #F4F4F4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div> <div style=\"background-color: #F4F4F4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div><\/div><div style=\"margin-left: 8px;\"> <div style=\" background-color: #F4F4F4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div> <div style=\" width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg)\"><\/div><\/div><div style=\"margin-left: auto;\"> <div style=\" width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div> <div style=\" background-color: #F4F4F4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div> <div style=\" width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div><\/div><\/div> <div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\"> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div> <div style=\" background-color: #F4F4F4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div><\/div><\/a><p style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; line-height:17px; margin-bottom:0; margin-top:8px; overflow:hidden; padding:8px 0 7px; text-align:center; text-overflow:ellipsis; white-space:nowrap;\"><a href=\"https:\/\/www.instagram.com\/reel\/DRKA-1QAqO_\/?utm_source=ig_embed&amp;utm_campaign=loading\" style=\" color:#c9c8cd; font-family:Arial,sans-serif; font-size:14px; font-style:normal; font-weight:normal; line-height:17px; text-decoration:none;\" target=\"_blank\" rel=\"noopener\">DMD Hastal\u0131\u011f\u0131, Ali Taghizadeh (@alitgzd)&#039;in payla\u015ft\u0131\u011f\u0131 bir g\u00f6nderi<\/a><\/p><\/div><\/blockquote>\n<script async src=\"\/\/www.instagram.com\/embed.js\"><\/script>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Aqu\u00ed est\u00e1 el texto completo del v\u00eddeo:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hola a todos, soy Ali Taghizadeh.<br>Soy de la Universidad Bilecik \u015eeyh Edebali.<br>Soy profesor asociado de Farmacolog\u00eda M\u00e9dica.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Quiero presentarles a nuestra DMD ANKA para los extranjeros que viven fuera de Turqu\u00eda.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Podemos evaluar DMD ANKA en tres temas diferentes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>La primera es la secuencia de ARNm que utilizamos en el DMD ANKA.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Como ya sab\u00e9is, la distrofina tiene la prote\u00edna m\u00e1s grande del cuerpo y la secuencia de ARNm m\u00e1s larga.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Se trata de una mol\u00e9cula de fosfato de casi quince mil mol\u00e9culas, cuya estabilizaci\u00f3n es muy dif\u00edcil y representa un gran desaf\u00edo para los cient\u00edficos. Ahora podemos producirla y estabilizarla sin utilizar productos qu\u00edmicos ni sustancias peligrosas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>En el segundo paso queremos que DMD ANKA participe en los ciclos celulares o la fisiolog\u00eda celular.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eso significa que cuando administramos DMD ANKA al paciente, queremos que DMD ANKA llegue a trav\u00e9s de la sangre a las c\u00e9lulas y luego, una vez all\u00ed, se clasifique fisiol\u00f3gicamente. La c\u00e9lula pensar\u00e1: &quot;Este es mi producto, lo gener\u00e9 a partir de nuestro ADN&quot;, y este ARNm se traducir\u00e1 a prote\u00edna mediante el sistema reticuloendopl\u00e1smico (Ras) y luego se localizar\u00e1 en las c\u00e9lulas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nuestro tercer paso consiste en que las c\u00e9lulas comiencen a recuperarse y regenerarse desde el principio, en las primeras horas, mediante la participaci\u00f3n de nuestro ARNm en la fisiolog\u00eda celular.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Es muy importante porque cuando queremos dar un paso con una distrofina funcional, necesitamos comprender que es mi ARNm y que lo traducir\u00e9 a prote\u00edna, y tambi\u00e9n lo enviar\u00e9 a la membrana para que haga su trabajo y la c\u00e9lula lo procese.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Es muy importante porque la fibrosis y todos los procesos inflamatorios realizados por las c\u00e9lulas del cuerpo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cuando queremos acabar con la fibrosis y la inflamaci\u00f3n, necesitamos hacerlo jugando con las c\u00e9lulas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Eso significa que despu\u00e9s de que la distrofina se localiza en la membrana y se une a los distroglicanos, los sarcoglicanos, al inspeccionar la actina alfa aferente y ofrecer antineuronas, se reconstruyen, recuperan y regeneran las neuronas que conectan el m\u00fasculo con el cerebro, y de esta manera se inicia la eliminaci\u00f3n de la fibrosis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Es importante para nosotros porque el DMD ANKA se puede utilizar tanto en adultos como en ni\u00f1os con distrofia muscular de Duchenne.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sigue esta p\u00e1gina<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/es\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">Todos los ensayos cl\u00ednicos para la distrofia muscular de Duchenne<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Turkish pharmacologist Assoc. Prof. Dr. Ali Taghizadeh announced in English to his followers abroad the mRNA therapy he is working on for Duchenne Muscular Dystrophy. Associate Professor Dr. Ali Taghizadeh shared an English-language information video on his Instagram account about DMD ANKA, the mRNA therapy he developed for Duchenne muscular dystrophy. Learn More: mRNA Studies [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5165,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[345,333,359,202,455],"class_list":["post-5164","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-ali-taghizadeh","tag-dmd-anka","tag-full-length-dystrophin","tag-mrna","tag-mrna-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/posts\/5164","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/comments?post=5164"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/posts\/5164\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/media\/5165"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/media?parent=5164"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/categories?post=5164"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/es\/wp-json\/wp\/v2\/tags?post=5164"}],"curies":[{"name":"gracias","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}