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What does Reading Frame mean in Duchenne (DMD)?

Reading Frame is a Duchenne (DMD) disease term, explained for patients, families, and caregivers.

Category: Duchenne Muscular Dystrophy: Disease Terminology

Reading Frame

The way a genetic sequence is divided into groups of three nucleotides, called codons, during protein production. If a DMD mutation disrupts this frame, the resulting dystrophin may be prematurely truncated or absent; preserving the frame can sometimes permit a shorter protein.

Updated November 3, 2026

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