{"id":8865,"date":"2026-10-14T15:15:01","date_gmt":"2026-10-14T12:15:01","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=8865"},"modified":"2026-10-14T15:28:15","modified_gmt":"2026-10-14T12:28:15","slug":"entr-601-45-dystrophin-production-duchenne","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/entr-601-45-dystrophin-production-duchenne\/","title":{"rendered":"Entrada Therapeutics ENTR-601-45: \u062f\u0631\u0627\u0633\u0629 \u062d\u0648\u0644 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0627\u0644\u0645\u0628\u0643\u0631 \u062a\u064f\u0638\u0647\u0631 \u0632\u064a\u0627\u062f\u0629 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Entrada Therapeutics \u0639\u0646 \u0646\u062a\u0627\u0626\u062c \u0623\u0648\u0644\u064a\u0629 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0645\u0646 \u062f\u0631\u0627\u0633\u062a\u0647\u0627 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u060c ELEVATE-45-201\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0642\u064a\u0651\u0645 ENTR-601-45 \u0644\u062f\u0649 \u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (\u062f\u0648\u0634\u064a\u0646).<\/strong> \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0633\u0644\u0627\u0645\u0629\u064b \u062c\u064a\u062f\u0629\u064b \u0648\u0632\u064a\u0627\u062f\u0629\u064b \u0637\u0641\u064a\u0641\u0629\u064b \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0628\u0639\u062f \u062a\u0644\u0642\u064a \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629. \u062a\u064f\u0639\u062f\u0651 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u062e\u0637\u0648\u0629\u064b \u0645\u0628\u0643\u0631\u0629\u064b \u0641\u064a \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u062d\u064a\u062b \u064a\u064f\u062e\u0637\u0637 \u0644\u0625\u0639\u0637\u0627\u0621 \u062c\u0631\u0639\u0627\u062a \u0623\u0639\u0644\u0649 \u0644\u062a\u0642\u064a\u064a\u0645 \u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0643\u0645\u064a\u0627\u062a \u0623\u0643\u0628\u0631 \u0645\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u0642\u0648\u0645 \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 1\/2 \u0628\u062a\u0642\u064a\u064a\u0645 ENTR-601-45 \u0644\u062f\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u064a \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u062a\u0623\u0643\u064a\u062f \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0637\u0641\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0648\u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-did-the-first-cohort-show\">\u0645\u0627\u0630\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u061f<\/a><ul><li><a href=\"#dystrophin-production-increased-by-0-10\">\u0627\u0632\u062f\u0627\u062f \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0628\u0645\u0642\u062f\u0627\u0631 0.10%<\/a><\/li><\/ul><\/li><li><a href=\"#safety-and-tolerability-results\">\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062a\u062d\u0645\u0644<\/a><ul><li><a href=\"#drug-exposure-matched-expectations\">\u062a\u0637\u0627\u0628\u0642\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u062a\u0648\u0642\u0639\u0627\u062a<\/a><\/li><\/ul><\/li><li><a href=\"#what-comes-next-for-entr-601-45\">\u0645\u0627 \u0647\u064a \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0644\u0640 ENTR-601-45\u061f<\/a><\/li><li><a href=\"#a-potentially-less-frequent-dosing-schedule\">\u062c\u062f\u0648\u0644 \u062c\u0631\u0639\u0627\u062a \u0623\u0642\u0644 \u062a\u0643\u0631\u0627\u0631\u064b\u0627<\/a><\/li><li><a href=\"#conclusion\">\u062e\u0627\u062a\u0645\u0629<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"what-did-the-first-cohort-show\" class=\"wp-block-heading\">\u0645\u0627\u0630\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u0636\u0645\u0646\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u062b\u0645\u0627\u0646\u064a\u0629 \u0645\u0634\u0627\u0631\u0643\u064a\u0646: \u062a\u0644\u0642\u0649 \u0633\u062a\u0629 \u0645\u0646\u0647\u0645 ENTR-601-45 \u0628\u062c\u0631\u0639\u0629 5 \u0645\u0644\u063a\/\u0643\u063a\u060c \u0628\u064a\u0646\u0645\u0627 \u062a\u0644\u0642\u0649 \u0627\u062b\u0646\u0627\u0646 \u062f\u0648\u0627\u0621\u064b \u0648\u0647\u0645\u064a\u064b\u0627.<\/strong> \u062a\u0644\u0642\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u062b\u0644\u0627\u062b \u062c\u0631\u0639\u0627\u062a \u062e\u0644\u0627\u0644 \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0645\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0645\u062a\u0635\u0627\u0639\u062f\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062d\u0642\u0642\u062a \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062a\u062d\u0645\u0644. \u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0623\u0647\u062f\u0627\u0641 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0644\u062f\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u0627\u0644\u0639\u0644\u0627\u062c.<\/p>\n\n\n\n<h3 id=\"dystrophin-production-increased-by-0-10\" class=\"wp-block-heading\">\u0627\u0632\u062f\u0627\u062f \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0628\u0645\u0642\u062f\u0627\u0631 0.10%<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u0643\u0627\u0646\u062a \u0623\u0647\u0645 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0647\u064a \u0632\u064a\u0627\u062f\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0642\u062f\u0631\u0647\u0627 0.10% \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0645\u0646 \u062e\u0637 \u0627\u0644\u0623\u0633\u0627\u0633 \u0628\u064a\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0633\u062a\u0629 \u0627\u0644\u0630\u064a\u0646 \u0639\u0648\u0644\u062c\u0648\u0627 \u0628\u0640 ENTR-601-45.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u0627\u0644\u0645\u0642\u0627\u0631\u0646\u0629\u060c \u0623\u0638\u0647\u0631\u062a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a \u0627\u0646\u062e\u0641\u0627\u0636\u064b\u0627 \u0645\u062a\u0648\u0633\u0637\u064b\u0627 \u0642\u062f\u0631\u0647 0.02% \u0641\u064a \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0639\u0646 \u062e\u0637 \u0627\u0644\u0623\u0633\u0627\u0633.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0643\u0645\u0627 \u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0632\u064a\u0627\u062f\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0642\u062f\u0631\u0647\u0627 0.15% \u0641\u064a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u060c \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u062a\u0648\u0633\u0637 \u0642\u062f\u0631\u0647 0.04% \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u064f\u0634\u064a\u0631 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0628\u062f\u0626\u064a\u064b\u0627 \u0625\u0644\u0649 \u0623\u0646 ENTR-601-45 \u064a\u064f\u062d\u0642\u0642 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0631\u062c\u0648\u0629. \u0645\u0639 \u0630\u0644\u0643\u060c \u0643\u0627\u0646\u062a \u0627\u0644\u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u0645\u0644\u062d\u0648\u0638\u0629 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0639\u0646\u062f \u0647\u0630\u0647 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0637\u0641\u064a\u0641\u0629\u060c \u0648\u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0644\u0641\u0647\u0645 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649.<\/p>\n\n\n\n<h2 id=\"safety-and-tolerability-results\" class=\"wp-block-heading\">\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062a\u062d\u0645\u0644<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u0631\u0643\u0628 ENTR-601-45 \u0645\u0633\u062a\u0648\u0649 \u0623\u0645\u0627\u0646 \u0648\u062a\u062d\u0645\u0644 \u062c\u064a\u062f\u064a\u0646 \u0639\u0646\u062f \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u0628\u0627\u0644\u063a\u0629 5 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0643\u0627\u0646 \u0627\u0644\u0635\u062f\u0627\u0639 \u0623\u0643\u062b\u0631 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u062c\u0627\u0646\u0628\u064a\u0629 \u0634\u064a\u0648\u0639\u064b\u0627 \u0627\u0644\u062a\u064a \u0638\u0647\u0631\u062a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u062d\u064a\u062b \u062a\u0645 \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u062e\u0645\u0633 \u062d\u0627\u0644\u0627\u062a \u0644\u062f\u0649 \u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u062b\u0646\u064a\u0646. \u0639\u0627\u0646\u0649 \u0623\u062d\u062f \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0645\u0646 \u0639\u0631\u0636\u064a\u0646 \u062c\u0627\u0646\u0628\u064a\u064a\u0646 \u062e\u0637\u064a\u0631\u064a\u0646 \u0638\u0647\u0631\u0627 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c: \u0627\u0644\u0642\u064a\u0621 \u0648\u0627\u0644\u062d\u0645\u0649. \u0648\u0642\u062f \u062a\u0639\u0627\u0641\u0649 \u0643\u0644\u0627\u0647\u0645\u0627 \u0644\u0627\u062d\u0642\u064b\u0627.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0645 \u064a\u0646\u0633\u062d\u0628 \u0623\u064a \u0645\u0634\u0627\u0631\u0643 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u0648\u0627\u0646\u0636\u0645 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0625\u0644\u0649 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062a\u0648\u0633\u0639\u064a\u0629 \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0643\u0645\u0627 \u0644\u0645 \u062a\u064f\u0628\u0644\u063a \u0627\u0644\u0634\u0631\u0643\u0629 \u0639\u0646 \u0623\u064a \u0645\u062e\u0627\u0648\u0641 \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0633\u064a\u0648\u0645 \u0623\u0648 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0643\u0644\u0649. \u0648\u0643\u0627\u0646\u062a \u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u0643\u0644\u0649\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0639\u062f\u0644 \u0627\u0644\u062a\u0631\u0634\u064a\u062d \u0627\u0644\u0643\u0628\u064a\u0628\u064a \u0627\u0644\u0645\u0642\u062f\u0631 (eGFR) \u0648\u0627\u0644\u0633\u064a\u0633\u062a\u0627\u062a\u064a\u0646 C\u060c \u0636\u0645\u0646 \u0627\u0644\u0645\u0639\u062f\u0644\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0639\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u0627\u0644\u0639\u0644\u0627\u062c. \u0648\u0643\u0627\u0646\u062a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u063a\u0646\u064a\u0633\u064a\u0648\u0645 \u0623\u064a\u0636\u0627\u064b \u0636\u0645\u0646 \u0627\u0644\u0645\u0639\u062f\u0644 \u0627\u0644\u0637\u0628\u064a\u0639\u064a.<\/p>\n\n\n\n<h3 id=\"drug-exposure-matched-expectations\" class=\"wp-block-heading\">\u062a\u0637\u0627\u0628\u0642\u062a \u0646\u0633\u0628\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u062f\u0648\u0627\u0621 \u0645\u0639 \u0627\u0644\u062a\u0648\u0642\u0639\u0627\u062a<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0643\u0627\u0646\u062a \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0642\u0627\u0633\u0629 \u0644\u0640 ENTR-601-45 \u0641\u064a \u0627\u0644\u062f\u0645 \u0645\u062a\u0648\u0627\u0641\u0642\u0629 \u0645\u0639 \u0627\u0644\u062a\u0648\u0642\u0639\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0646\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0627\u0628\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0627\u062a \u063a\u064a\u0631 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0627\u0644\u0635\u063a\u064a\u0631\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u0648\u0641\u0642\u0627\u064b \u0644\u0644\u0634\u0631\u0643\u0629\u060c \u0641\u0625\u0646 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u062a\u062f\u0639\u0645 \u062a\u0648\u0642\u0639\u0627\u062a\u0647\u0627 \u0628\u0623\u0646 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649 \u0642\u062f \u062a\u0624\u062f\u064a \u0625\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0644\u062f\u0648\u0627\u0621 \u0648\u0632\u064a\u0627\u062f\u0629 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646.<\/p>\n\n\n\n<h2 id=\"what-comes-next-for-entr-601-45\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u064a \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0644\u0640 ENTR-601-45\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u062a\u0648\u0642\u0639 \u0627\u0644\u0634\u0631\u0643\u0629 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649 \u0641\u064a \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0628\u0625\u0645\u0643\u0627\u0646 ENTR-601-45 \u0625\u062d\u062f\u0627\u062b \u0632\u064a\u0627\u062f\u0629 \u0623\u0643\u0628\u0631 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u0631\u0628\u0645\u0627 \u062a\u0648\u0641\u064a\u0631 \u0641\u0648\u0627\u0626\u062f \u0648\u0638\u064a\u0641\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0623\u0643\u0645\u0644\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629\u060c \u0627\u0644\u062a\u064a \u062a\u0642\u064a\u0651\u0645 \u062c\u0631\u0639\u0629 10 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645\u060c \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u0633\u062c\u064a\u0644. \u0648\u064a\u062a\u0648\u0642\u0639 \u0645\u0634\u0631\u0648\u0639 Entrada Therapeutics \u0646\u0634\u0631 \u0628\u064a\u0627\u0646\u0627\u062a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u064a \u0627\u0644\u0646\u0635\u0641 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2027.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0646 \u0627\u0644\u0645\u062e\u0637\u0637 \u0625\u062c\u0631\u0627\u0621 \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0649 \u0645\u062c\u0645\u0648\u0639\u0629 \u062b\u0627\u0644\u062b\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u062c\u0631\u0639\u0627\u062a \u062a\u0635\u0644 \u0625\u0644\u0649 15 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0643\u0645\u0627 \u0627\u0646\u062a\u0642\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0625\u0644\u0649 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629\u060c \u062d\u064a\u062b \u0633\u064a\u062a\u0644\u0642\u0648\u0646 \u0633\u062a \u062c\u0631\u0639\u0627\u062a \u0645\u0646 ENTR-601-45 \u0628\u0645\u0639\u062f\u0644 5 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0645 \u064a\u064f\u062a\u0648\u0642\u0639 \u0623\u0648 \u064a\u064f\u0628\u0644\u063a \u0639\u0646 \u0623\u064a \u0641\u0627\u0626\u062f\u0629 \u0648\u0638\u064a\u0641\u064a\u0629 \u0645\u0644\u062d\u0648\u0638\u0629 \u0628\u0639\u062f \u062b\u0644\u0627\u062b \u062c\u0631\u0639\u0627\u062a \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649. \u0633\u064a\u062a\u0645 \u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0648\u0638\u064a\u0641\u064a \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062c\u0631\u0639\u0627\u062a \u0623\u0639\u0644\u0649 \u0648\u0644\u0641\u062a\u0631\u0627\u062a \u0639\u0644\u0627\u062c \u0623\u0637\u0648\u0644 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0648\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u062a\u0633\u0645\u064a\u0629. \u0644\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a: <a href=\"https:\/\/dmdwarrior.com\/ar\/duchenne-exon-deletion-tool\/\" target=\"_blank\" rel=\"noopener\">\u0623\u062f\u0627\u0629 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a DMDWarrior<\/a><\/p>\n\n\n\n<h2 id=\"a-potentially-less-frequent-dosing-schedule\" class=\"wp-block-heading\">\u062c\u062f\u0648\u0644 \u062c\u0631\u0639\u0627\u062a \u0623\u0642\u0644 \u062a\u0643\u0631\u0627\u0631\u064b\u0627<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0635\u064f\u0645\u0645 \u062f\u0648\u0627\u0621 ENTR-601-45 \u0644\u064a\u062a\u0645 \u062a\u0646\u0627\u0648\u0644\u0647 \u0645\u0631\u0629 \u0643\u0644 \u0633\u062a\u0629 \u0623\u0633\u0627\u0628\u064a\u0639. \u0642\u062f \u064a\u0639\u0646\u064a \u0647\u0630\u0627 \u0627\u0644\u062c\u062f\u0648\u0644 \u062d\u0648\u0627\u0644\u064a \u062a\u0633\u0639 \u062c\u0631\u0639\u0627\u062a \u0633\u0646\u0648\u064a\u0627\u064b\u060c \u0645\u0642\u0627\u0631\u0646\u0629\u064b \u0628\u0623\u0643\u062b\u0631 \u0645\u0646 50 \u062c\u0631\u0639\u0629 \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0623\u0633\u0628\u0648\u0639\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u064f\u0639\u062f\u0651 \u0627\u062d\u062a\u0645\u0627\u0644 \u062a\u0642\u0644\u064a\u0644 \u0639\u062f\u062f \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u062c\u0627\u0646\u0628\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0645\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0642\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0644\u0627 \u064a\u0632\u0627\u0644 \u064a\u062a\u0639\u064a\u0646 \u0625\u062b\u0628\u0627\u062a \u0633\u0644\u0627\u0645\u062a\u0647 \u0648\u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0648\u0641\u0648\u0627\u0626\u062f\u0647 \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u062f\u0649 \u0627\u0644\u0637\u0648\u064a\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629.<\/p>\n\n\n\n<h2 id=\"conclusion\" class=\"wp-block-heading\">\u062e\u0627\u062a\u0645\u0629<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062d\u0642\u0642\u062a \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u062f\u0631\u0627\u0633\u0629 ELEVATE-45-201 \u0623\u0647\u062f\u0627\u0641\u0647\u0627 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062a\u062d\u0645\u0644\u060c \u0648\u0623\u0638\u0647\u0631\u062a \u0632\u064a\u0627\u062f\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0642\u062f\u0631\u0647\u0627 0.10% \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0645\u0639 ENTR-601-45 \u0628\u062c\u0631\u0639\u0629 5 \u0645\u0644\u063a\/\u0643\u063a. \u0643\u0645\u0627 \u0632\u0627\u062f \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0639\u0646 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0623\u0633\u0627\u0633\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0647\u0630\u0647 \u0646\u062a\u0627\u0626\u062c \u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0623\u0648\u0644\u064a\u0629\u060c \u0648\u0644\u064a\u0633\u062a \u062f\u0644\u064a\u0644\u0627\u064b \u0639\u0644\u0649 \u0641\u0627\u0626\u062f\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u0648 \u0648\u0638\u064a\u0641\u064a\u0629 \u0645\u0624\u0643\u062f\u0629. \u0648\u0633\u062a\u0643\u0648\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0647\u0645\u0629 \u0627\u0644\u062a\u0627\u0644\u064a\u0629 \u0647\u064a \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0627\u0644\u0623\u0639\u0644\u0649\u060c \u0628\u062f\u0621\u064b\u0627 \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u062c\u0631\u0639\u0629 10 \u0645\u0644\u063a\u0645\/\u0643\u063a\u0645\u060c \u0648\u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0638\u0647\u0648\u0631\u0647\u0627 \u0641\u064a \u0627\u0644\u0646\u0635\u0641 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2027.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0643\u062a\u0634\u0641 \u0627\u0644\u0645\u0632\u064a\u062f<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/clinical-trials\/map\/\" target=\"_blank\" rel=\"noopener\">\u062e\u0631\u064a\u0637\u0629 \u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Entrada Therapeutics has announced positive initial results from its Exon 45 Skipping Study, ELEVATE-45-201, evaluating ENTR-601-45 in people with Duchenne muscular dystrophy (Duchenne). The first group of participants showed a favorable safety profile and a small increase in dystrophin production after receiving the initial dose. The findings are an early step in evaluating the treatment, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":8867,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[320,321,233,234,317,318,319],"class_list":["post-8865","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-elevate-45-201","tag-entr-601-45","tag-entrada","tag-entrada-therapeutics","tag-exon-45","tag-exon-45-skipping","tag-exon-45-skipping-therapy"],"subtitle":"\u0623\u0641\u0627\u062f \u062a\u0642\u0631\u064a\u0631 Entrada Therapeutics \u0628\u0646\u062a\u0627\u0626\u062c \u0623\u0648\u0644\u064a\u0629 \u0644\u0640 ENTR-601-45 \u0641\u064a \u0639\u0644\u0627\u062c \u062f\u0648\u0634\u064a\u0646. \u0648\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 ELEVATE-45-201 \u0632\u064a\u0627\u062f\u0629 \u0645\u062a\u0648\u0633\u0637\u0629 \u0642\u062f\u0631\u0647\u0627 0.10% \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0645\u0639 \u0627\u0644\u062a\u062e\u0637\u064a\u0637 \u0644\u062c\u0631\u0639\u0627\u062a \u0623\u0639\u0644\u0649 \u0644\u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0623\u0643\u0628\u0631.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/8865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=8865"}],"version-history":[{"count":3,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/8865\/revisions"}],"predecessor-version":[{"id":8870,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/8865\/revisions\/8870"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/8867"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=8865"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=8865"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=8865"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}