{"id":7976,"date":"2026-05-14T20:35:20","date_gmt":"2026-05-14T17:35:20","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=7976"},"modified":"2026-06-24T22:01:14","modified_gmt":"2026-06-24T19:01:14","slug":"avidity-biosciences-aoc-1044-safari44-phase-3-dmd-trial-nct07587242","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/avidity-biosciences-aoc-1044-safari44-phase-3-dmd-trial-nct07587242\/","title":{"rendered":"\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 Del-Zota SAFARI44: \u062f\u0631\u0627\u0633\u0629 \u062c\u062f\u064a\u062f\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u062a\u062a\u0648\u0627\u0635\u0644 \u0623\u0628\u062d\u0627\u062b \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (DMD) \u0645\u0639 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 Del-Zota SAFARI44 \u0644\u062a\u0642\u064a\u064a\u0645 \u0639\u0642\u0627\u0631 AOC 1044\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0633\u0645 \u062f\u064a\u0644\u0628\u0627\u0633\u064a\u0628\u0627\u0631\u062a \u0632\u0648\u062a\u0627\u062f\u064a\u0631\u0633\u0646. \u0648\u064a\u062c\u0631\u064a \u062a\u0637\u0648\u064a\u0631 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u062c\u0631\u064a\u0628\u064a \u0644\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0637\u0641\u0631\u0627\u062a DMD \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0639\u0644\u0627\u062c\u0647\u0627 \u0628\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-is-the-safari-44-trial\">\u0645\u0627 \u0647\u064a \u062a\u062c\u0631\u0628\u0629 SAFARI44\u061f<\/a><\/li><li><a href=\"#what-is-aoc-1044-delpacibart-zotadirsen\">\u0645\u0627 \u0647\u0648 Del-Zota (Delpacibart Zotadirsen)\u061f<\/a><\/li><li><a href=\"#how-the-study-will-work\">\u0643\u064a\u0641 \u0633\u062a\u0633\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/a><ul><li><a href=\"#randomized-treatment-period\">\u0641\u062a\u0631\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629<\/a><\/li><li><a href=\"#open-label-extension-ole\">\u0627\u0645\u062a\u062f\u0627\u062f \u0627\u0644\u062a\u0633\u0645\u064a\u0629 \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629 (OLE)<\/a><\/li><li><a href=\"#independent-safety-monitoring\">\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0629<\/a><\/li><\/ul><\/li><li><a href=\"#safari-44-timeline\">\u0627\u0644\u062c\u062f\u0648\u0644 \u0627\u0644\u0632\u0645\u0646\u064a SAFARI44<\/a><ul><li><a href=\"#estimated-study-dates\">\u0645\u0648\u0627\u0639\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629<\/a><\/li><li><a href=\"#planned-enrollment\">\u0627\u0644\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0647<\/a><\/li><\/ul><\/li><li><a href=\"#who-can-participate\">\u0645\u0646 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629\u061f<\/a><ul><li><a href=\"#key-inclusion-criteria\">\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0625\u062f\u0631\u0627\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629<\/a><\/li><li><a href=\"#key-exclusion-criteria\">\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629<\/a><\/li><\/ul><\/li><li><a href=\"#why-this-trial-matters-for-the-dmd-community\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u0647\u0630\u0647 \u0627\u0644\u0645\u062d\u0627\u0643\u0645\u0629 \u0645\u0647\u0645\u0629 \u0644\u0645\u062c\u062a\u0645\u0639 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a\u061f<\/a><\/li><li><a href=\"#contact-information\">\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0627\u062a\u0635\u0627\u0644<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"what-is-the-safari-44-trial\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u064a \u062a\u062c\u0631\u0628\u0629 SAFARI44\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062f\u0631\u0627\u0633\u0629 SAFARI44 \u0647\u064a \u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629\u060c \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629\u060c \u0645\u0636\u0628\u0648\u0637\u0629 \u0628\u0627\u0644\u063a\u0641\u0644\u060c \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629\u060c \u0645\u0635\u0645\u0645\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0633\u0644\u0627\u0645\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 \u062f\u0648\u0627\u0621 AOC 1044 (Del-Zota) \u0644\u062f\u0649 \u0627\u0644\u0623\u0648\u0644\u0627\u062f \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0645\u0624\u0647\u0644\u064a\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44. \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/del-zota-explore44-provides-nearly-30-normal-dystrophin-production-in-patients-amenable-to-exon-44-skipping\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u064a\u0648\u0641\u0631 Del-zota (EXPLORE44) \u0625\u0646\u062a\u0627\u062c\u064b\u0627 \u0637\u0628\u064a\u0639\u064a\u064b\u0627 \u062a\u0642\u0631\u064a\u0628\u064b\u0627 \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 30%<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u062a\u062f\u0631\u0633 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u062f\u0648\u0627\u0621 AOC 1044 \u0627\u0644\u0630\u064a \u064a\u064f\u0639\u0637\u0649 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u0648\u0631\u064a\u062f \u064a\u064f\u062d\u0633\u0651\u0646 \u0645\u0646 \u0646\u062a\u0627\u0626\u062c \u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0627\u0644\u0630\u064a\u0646 \u064a\u062d\u0645\u0644\u0648\u0646 \u0637\u0641\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646. \u064a\u064f\u0639\u0637\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062a\u0633\u0631\u064a\u0628 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0643\u0644 \u0633\u062a\u0629 \u0623\u0633\u0627\u0628\u064a\u0639.<\/p>\n\n\n\n<h2 id=\"what-is-aoc-1044-delpacibart-zotadirsen\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u0648 Del-Zota (Delpacibart Zotadirsen)\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u064f\u0639\u062f\u0651 Del-Zota \u0639\u0644\u0627\u062c\u064b\u0627 \u062a\u062c\u0631\u064a\u0628\u064a\u064b\u0627 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u060c \u0637\u064f\u0648\u0651\u0631 \u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0627\u0644\u062a\u064a \u064a\u064f\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u062a\u0641\u064a\u062f \u0645\u0646 \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44. \u064a\u0647\u062f\u0641 \u0639\u0644\u0627\u062c \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0625\u0644\u0649 \u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0623\u0642\u0635\u0631 \u0648\u0644\u0643\u0646\u0647 \u0641\u0639\u0627\u0644\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u064f\u0628\u0637\u0626 \u0645\u0646 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a. \u0644\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/mutations-and-deletions-amenable-to-exon-44-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"968\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg\" alt=\"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646\" class=\"wp-image-5275\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-968x1024.jpg 968w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-284x300.jpg 284w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-768x813.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1452x1536.jpg 1452w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-11x12.jpg 11w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-397x420.jpg 397w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-150x159.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-300x317.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-696x737.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping-1068x1130.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/11\/Deletions-Amenable-to-Exon-44-Skipping.jpg 1890w\" sizes=\"auto, (max-width: 968px) 100vw, 968px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u062e\u0644\u0627\u0641 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u062e\u0637\u0649 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u060c \u064a\u0633\u062a\u062e\u062f\u0645 Del-Zota \u062a\u0642\u0646\u064a\u0629 \u0627\u0642\u062a\u0631\u0627\u0646 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0635\u0645\u0645\u0629 \u0644\u062a\u062d\u0633\u064a\u0646 \u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u0639\u0644\u0627\u062c \u0625\u0644\u0649 \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a.<\/p>\n\n\n\n<h2 id=\"how-the-study-will-work\" class=\"wp-block-heading\">\u0643\u064a\u0641 \u0633\u062a\u0633\u064a\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/h2>\n\n\n\n<h3 id=\"randomized-treatment-period\" class=\"wp-block-heading\">\u0641\u062a\u0631\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u064a\u062d\u0635\u0644 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0627\u0644\u0645\u0633\u062c\u0644\u0648\u0646 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 SAFARI44 \u0639\u0644\u0649 \u0623\u062d\u062f \u0627\u0644\u062e\u064a\u0627\u0631\u064a\u0646 \u0627\u0644\u062a\u0627\u0644\u064a\u064a\u0646:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Del-Zota (\u062f\u064a\u0644\u0628\u0627\u0633\u064a\u0628\u0627\u0631\u062a \u0632\u0648\u062a\u0627\u062f\u064a\u0631\u0633\u0646)<\/li>\n\n\n\n<li>\u062f\u0648\u0627\u0621 \u0648\u0647\u0645\u064a<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u064a\u062a\u0645 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0643\u0644 \u0633\u062a\u0629 \u0623\u0633\u0627\u0628\u064a\u0639 \u0628\u0625\u062c\u0645\u0627\u0644\u064a \u062a\u0633\u0639 \u062c\u0631\u0639\u0627\u062a \u062e\u0644\u0627\u0644 \u0627\u0644\u0623\u0633\u0627\u0628\u064a\u0639 \u0627\u0644\u0640 54 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n\n\n\n<h3 id=\"open-label-extension-ole\" class=\"wp-block-heading\">\u0627\u0645\u062a\u062f\u0627\u062f \u0627\u0644\u062a\u0633\u0645\u064a\u0629 \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629 (OLE)<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u0639\u062f \u0627\u0643\u062a\u0645\u0627\u0644 \u0627\u0644\u062c\u0632\u0621 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u060c \u064a\u0645\u0643\u0646 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u062f\u062e\u0648\u0644 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u062a\u0645\u062f\u064a\u062f \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u062a\u0633\u0645\u064a\u0629 \u0644\u0645\u062f\u0629 54 \u0623\u0633\u0628\u0648\u0639\u064b\u0627. \u062e\u0644\u0627\u0644 \u0647\u0630\u0647 \u0627\u0644\u0641\u062a\u0631\u0629\u060c \u0633\u064a\u062a\u0644\u0642\u0649 \u0643\u0644 \u0645\u0634\u0627\u0631\u0643 \u062f\u0648\u0627\u0621 Del-Zota \u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u062e\u0635\u064a\u0635\u0647 \u0644\u0647 \u0641\u064a \u0627\u0644\u0623\u0635\u0644.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062c\u0631\u0639\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0641\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639 102\u060c \u064a\u0644\u064a\u0647\u0627 \u062a\u0642\u064a\u064a\u0645\u0627\u062a \u0625\u0636\u0627\u0641\u064a\u0629 \u0648\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u062d\u062a\u0649 \u0627\u0644\u0623\u0633\u0628\u0648\u0639 114.<\/p>\n\n\n\n<h3 id=\"independent-safety-monitoring\" class=\"wp-block-heading\">\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0644\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u062a\u0642\u0648\u0645 \u0644\u062c\u0646\u0629 \u0645\u0633\u062a\u0642\u0644\u0629 \u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a (IDMC) \u0628\u0645\u0631\u0627\u062c\u0639\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u062a\u062d\u0645\u0644 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0628\u0627\u0646\u062a\u0638\u0627\u0645 \u0637\u0648\u0627\u0644 \u0641\u062a\u0631\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n\n\n\n<h2 id=\"safari-44-timeline\" class=\"wp-block-heading\">\u0627\u0644\u062c\u062f\u0648\u0644 \u0627\u0644\u0632\u0645\u0646\u064a SAFARI44<\/h2>\n\n\n\n<h3 id=\"estimated-study-dates\" class=\"wp-block-heading\">\u0645\u0648\u0627\u0639\u064a\u062f \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0628\u062f\u0627\u064a\u0629 \u0627\u0644\u062f\u0631\u0627\u0633\u0629: \u064a\u0648\u0646\u064a\u0648 2026<\/li>\n\n\n\n<li>\u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0625\u0646\u062c\u0627\u0632 \u0627\u0644\u0623\u0633\u0627\u0633\u064a: \u0645\u0627\u064a\u0648 2029<\/li>\n\n\n\n<li>\u062a\u0627\u0631\u064a\u062e \u0625\u062a\u0645\u0627\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629: \u064a\u0648\u0644\u064a\u0648 2030<\/li>\n<\/ul>\n\n\n\n<h3 id=\"planned-enrollment\" class=\"wp-block-heading\">\u0627\u0644\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0647<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u062e\u0637\u0637 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0644\u062a\u0633\u062c\u064a\u0644 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 70 \u0645\u0634\u0627\u0631\u0643\u064b\u0627 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u062f\u062e\u0644\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629.<\/p>\n\n\n\n<h2 id=\"who-can-participate\" class=\"wp-block-heading\">\u0645\u0646 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629\u061f<\/h2>\n\n\n\n<h3 id=\"key-inclusion-criteria\" class=\"wp-block-heading\">\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0625\u062f\u0631\u0627\u062c \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0644\u062a\u0623\u0647\u0644 \u0644\u062f\u0631\u0627\u0633\u0629 SAFARI44\u060c \u064a\u062c\u0628 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0645\u0627 \u064a\u0644\u064a:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0627\u0644\u0631\u062c\u0627\u0644 \u0627\u0644\u0642\u0627\u062f\u0631\u0648\u0646 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u064a \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0625\u0635\u0627\u0628\u062a\u0647\u0645 \u0628\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a<\/li>\n\n\n\n<li>\u0648\u062c\u0648\u062f \u0637\u0641\u0631\u0629 \u062c\u064a\u0646\u064a\u0629 \u0645\u0624\u0643\u062f\u0629 \u0641\u064a \u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44<\/li>\n\n\n\n<li>\u0623\u0646 \u064a\u0643\u0648\u0646 \u0639\u0645\u0631\u0647 \u0628\u064a\u0646 \u0633\u0646\u062a\u064a\u0646 \u0641\u0645\u0627 \u0641\u0648\u0642 (\u0637\u0641\u0644\u060c \u0628\u0627\u0644\u063a\u060c \u0628\u0627\u0644\u063a \u0643\u0628\u064a\u0631 \u0627\u0644\u0633\u0646)<\/li>\n\n\n\n<li>\u0627\u0633\u062a\u0643\u0645\u0627\u0644 \u0627\u0644\u062a\u0642\u064a\u064a\u0645\u0627\u062a \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0637\u0644\u0648\u0628\u0629 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0641\u062d\u0635<\/li>\n\n\n\n<li>\u064a\u062c\u0628 \u0627\u0644\u0627\u0644\u062a\u0632\u0627\u0645 \u0628\u0646\u0638\u0627\u0645 \u0639\u0644\u0627\u062c\u064a \u0645\u0633\u062a\u0642\u0631 \u0628\u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0643\u0648\u0633\u062a\u064a\u0631\u0648\u064a\u062f\u0627\u062a \u0644\u0645\u062f\u0629 \u0633\u062a\u0629 \u0623\u0634\u0647\u0631 \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0642\u0628\u0644 \u0628\u062f\u0621 \u0627\u0644\u0639\u0644\u0627\u062c<\/li>\n<\/ul>\n\n\n\n<h3 id=\"key-exclusion-criteria\" class=\"wp-block-heading\">\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0642\u062f \u0644\u0627 \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0645\u0624\u0647\u0644\u064a\u0646 \u0625\u0630\u0627 \u0643\u0627\u0646\u0648\u0627:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0633\u0628\u0642 \u0623\u0646 \u062a\u0644\u0642\u0649 \u0639\u0644\u0627\u062c\u064b\u0627 \u062c\u064a\u0646\u064a\u064b\u0627 \u0623\u0648 \u0639\u0644\u0627\u062c\u064b\u0627 \u062e\u0644\u0648\u064a\u064b\u0627<\/li>\n\n\n\n<li>\u0627\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0627\u062c\u064b\u0627 \u0622\u062e\u0631 \u0628\u0627\u0644\u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u062e\u0644\u0627\u0644 \u0633\u062a\u0629 \u0623\u0634\u0647\u0631 \u0642\u0628\u0644 \u0627\u0644\u062a\u0633\u062c\u064a\u0644.<\/li>\n\n\n\n<li>\u0642\u064a\u0645 \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u062e\u0627\u0631\u062c \u062d\u062f\u0648\u062f \u0627\u0644\u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644<\/li>\n\n\n\n<li>\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645 \u062a\u063a\u064a\u064a\u0631\u0647\u0627 \u0645\u0624\u062e\u0631\u0627\u064b \u0645\u062b\u0644 \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0646\u0645\u0648 \u0623\u0648 \u0627\u0644\u062a\u0633\u062a\u0648\u0633\u062a\u064a\u0631\u0648\u0646 \u0623\u0648 \u062c\u064a\u0641\u064a\u0646\u0648\u0633\u062a\u0627\u062a<\/li>\n<\/ul>\n\n\n\n<h2 id=\"why-this-trial-matters-for-the-dmd-community\" class=\"wp-block-heading\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u0647\u0630\u0647 \u0627\u0644\u0645\u062d\u0627\u0643\u0645\u0629 \u0645\u0647\u0645\u0629 \u0644\u0645\u062c\u062a\u0645\u0639 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0627 \u062a\u0632\u0627\u0644 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u062a\u062e\u0637\u0649 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0645\u0646 \u0623\u0647\u0645 \u0627\u0644\u0623\u0633\u0627\u0644\u064a\u0628 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0641\u064a \u0623\u0628\u062d\u0627\u062b \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a. \u0648\u0631\u063a\u0645 \u0648\u062c\u0648\u062f \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u062e\u0637\u0649 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0644\u0639\u0644\u0627\u062c \u0623\u0647\u062f\u0627\u0641 \u0625\u0643\u0633\u0648\u0646\u064a\u0629 \u0623\u062e\u0631\u0649\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062e\u0637\u064a \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44 \u0644\u0627 \u062a\u0632\u0627\u0644 \u0645\u062d\u062f\u0648\u062f\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0642\u062f \u062a\u0648\u0641\u0631 \u062a\u062c\u0631\u0628\u0629 SAFARI44 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0645\u0647\u0645\u0629 \u062d\u0648\u0644 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 AOC 1044 \u064a\u0645\u0643\u0646\u0647 \u062a\u062d\u0633\u064a\u0646 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0628\u0623\u0645\u0627\u0646 \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u062a\u0639\u0644\u0645 \u0623\u0643\u062b\u0631:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/upcoming-exon-44-skipping-therapies-for-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 44 \u0627\u0644\u0642\u0627\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u062f\u0648\u0634\u064a\u0646<\/a><\/p>\n\n\n\n<h2 id=\"contact-information\" class=\"wp-block-heading\">\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0627\u062a\u0635\u0627\u0644<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0645 \u062a\u0645\u0648\u064a\u0644 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0646 \u0642\u0628\u0644 Avidity Biosciences.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0631\u0642\u0645 \u0627\u0644\u0647\u0627\u062a\u0641: 858-771-7038<\/li>\n\n\n\n<li>\u0628\u0631\u064a\u062f \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a: <a>medinfo@aviditybio.com<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u062d\u0627\u0644\u064a\u0627\u064b\u060c \u0644\u0645 \u064a\u062a\u0645 \u0646\u0634\u0631 \u0623\u064a \u0645\u0648\u0627\u0642\u0639 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u0634\u0643\u0644 \u0639\u0644\u0646\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u0627\u0628\u0639 \u0647\u0630\u0647 \u0627\u0644\u0635\u0641\u062d\u0629<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Duchenne muscular dystrophy (DMD) research continues to move forward with the launch of the Del-Zota SAFARI44 Phase 3 clinical trial evaluating AOC 1044, also known as delpacibart zotadirsen. This investigational therapy is being developed for individuals with DMD mutations amenable to exon 44 skipping. What Is the SAFARI44 Trial? The SAFARI44 study is a randomized, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7979,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[459,126,137,298,397,141,127,246,77,178,779],"class_list":["post-7976","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-aoc-1044","tag-avidity-biosciences","tag-clinical-trial","tag-del-zota","tag-delpacibart-zotadirsen","tag-exon-44","tag-exon-44-skipping","tag-exon-44-skipping-therapies","tag-exon-skipping","tag-exon-skipping-therapies","tag-safari44"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/7976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=7976"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/7976\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/7979"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=7976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=7976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=7976"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}