{"id":7974,"date":"2026-05-27T17:33:34","date_gmt":"2026-05-27T14:33:34","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=7974"},"modified":"2026-05-27T17:33:35","modified_gmt":"2026-05-27T14:33:35","slug":"dyne-251-z-rostudirsen-phase-3-forzetto-clinical-trial","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/dyne-251-z-rostudirsen-phase-3-forzetto-clinical-trial\/","title":{"rendered":"\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0639\u0642\u0627\u0631 Z-Rostudirsen (DYNE-251 \u0648FORZETTO) \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a (DMD) \u062a\u0628\u062f\u0623 \u0631\u0633\u0645\u064a\u064b\u0627"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Dyne Therapeutics \u0639\u0646 \u0628\u062f\u0621 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u062a\u062c\u0631\u0628\u0629 FORZETTO (NCT07608432) \u0644\u0639\u0642\u0627\u0631 Z-Rostudirsen \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a\u060c \u0645\u0645\u0627 \u064a\u0645\u062b\u0644 \u062e\u0637\u0648\u0629 \u0631\u0626\u064a\u0633\u064a\u0629 \u0623\u062e\u0631\u0649 \u0625\u0644\u0649 \u0627\u0644\u0623\u0645\u0627\u0645 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u0636\u0631\u0631\u0629 \u0645\u0646 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a (DMD).<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u062a\u0642\u064a\u0651\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629 \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u062f\u0648\u0627\u0621 z-rostudirsen (DYNE-251) \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0643\u0646 \u0639\u0644\u0627\u062c\u0647\u0645 \u0628\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51. \u0643\u0645\u0627 \u062a\u062e\u0637\u0637 \u0627\u0644\u0634\u0631\u0643\u0629 \u0644\u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628 \u062a\u0631\u062e\u064a\u0635 \u0628\u064a\u0648\u0644\u0648\u062c\u064a (BLA) \u0625\u0644\u0649 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0644\u062f\u0648\u0627\u0621 FDA \u0641\u064a \u0648\u0642\u062a \u0644\u0627\u062d\u0642 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0631\u0628\u0639 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u0633\u0631\u064a\u0639\u0629. \u0644\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a: <a href=\"https:\/\/dmdwarrior.com\/ar\/biologics-license-application-bla\/\" target=\"_blank\" data-type=\"post\" data-id=\"5027\" rel=\"noreferrer noopener\">\u0645\u0627\u0630\u0627 \u062a\u0639\u0646\u064a BLA\u061f<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u064a\u062a\u0645 \u0639\u0631\u0636 \u062a\u0635\u0645\u064a\u0645 \u062a\u062c\u0631\u0628\u0629 FORZETTO \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0624\u062a\u0645\u0631 \u0627\u0644\u062f\u0648\u0644\u064a \u0627\u0644\u062a\u0627\u0633\u0639 \u0639\u0634\u0631 \u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0644\u0623\u0639\u0635\u0627\u0628 (ICNMD) \u0641\u064a \u0641\u0644\u0648\u0631\u0646\u0633\u0627\u060c \u0625\u064a\u0637\u0627\u0644\u064a\u0627.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-is-z-rostudirsen-dyne-251\">\u0645\u0627 \u0647\u0648 Z-Rostudirsen (DYNE-251)\u061f<\/a><\/li><li><a href=\"#how-the-forzetto-phase-3-trial-will-work\">\u0643\u064a\u0641 \u0633\u062a\u0639\u0645\u0644 \u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 FORZETTO<\/a><\/li><li><a href=\"#primary-endpoint-focuses-on-muscle-function\">\u062a\u0631\u0643\u0632 \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0639\u0644\u0649 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a<\/a><\/li><li><a href=\"#additional-secondary-endpoints-in-the-forzetto-study\">\u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 FORZETTO<\/a><\/li><li><a href=\"#fda-alignment-and-accelerated-approval-plans\">\u062e\u0637\u0637 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0639\u062c\u0644\u0629 FDA<\/a><\/li><li><a href=\"#why-the-dyne-therapeutics-phase-3-forzetto-trial-of-z-rostudirsen-for-dmd-matters\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 Dyne Therapeutics FORZETTO \u0644\u0639\u0642\u0627\u0631 Z-Rostudirsen \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0645\u0647\u0645\u0629\u061f<\/a><\/li><li><a href=\"#contact-information\">\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0627\u062a\u0635\u0627\u0644<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"what-is-z-rostudirsen-dyne-251\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u0648 Z-Rostudirsen (DYNE-251)\u061f<\/h2>\n\n\n\n<h3 id=\"a-next-generation-exon-51-skipping-therapy\" class=\"wp-block-heading\">\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u062a\u0627\u0644\u064a \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Z-rostudirsen\u060c \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0633\u0645 DYNE-251\u060c \u0647\u0648 \u0639\u0644\u0627\u062c \u062a\u062c\u0631\u064a\u0628\u064a \u0645\u0635\u0645\u0645 \u0644\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a DMD \u0648\u0627\u0644\u0630\u064a\u0646 \u064a\u0645\u0643\u0646\u0647\u0645 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0625\u0644\u0649 \u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u062c\u0633\u0645 \u0639\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0634\u0628\u0647 \u0627\u0644\u0643\u0627\u0645\u0644 \u0641\u064a \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0644\u062c\u0647\u0627\u0632 \u0627\u0644\u0639\u0635\u0628\u064a \u0627\u0644\u0645\u0631\u0643\u0632\u064a. \u064a\u064f\u0639\u062f \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0636\u0631\u0648\u0631\u064a\u064b\u0627 \u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0645\u0646 \u0627\u0644\u062a\u0644\u0641\u060c \u0648\u064a\u0624\u062f\u064a \u063a\u064a\u0627\u0628\u0647 \u0625\u0644\u0649 \u0636\u0639\u0641 \u0639\u0636\u0644\u064a \u062a\u062f\u0631\u064a\u062c\u064a \u0644\u062f\u0649 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u0641\u0642\u064b\u0627 \u0644\u0640 Dyne Therapeutics\u060c \u0641\u0625\u0646 \u0647\u062f\u0641 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u064a\u0633 \u0641\u0642\u0637 \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a\u0629\u060c \u0648\u0644\u0643\u0646 \u0623\u064a\u0636\u064b\u0627 \u0645\u0633\u0627\u0639\u062f\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0639\u0644\u0649 \u0627\u0644\u062a\u062d\u0631\u0643 \u0628\u0634\u0643\u0644 \u0623\u0641\u0636\u0644\u060c \u0648\u0627\u0644\u062a\u0646\u0641\u0633 \u0628\u0634\u0643\u0644 \u0623\u0641\u0636\u0644\u060c \u0648\u062a\u062d\u0633\u064a\u0646 \u0646\u0648\u0639\u064a\u0629 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u064a\u0648\u0645\u064a\u0629.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"847\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg\" alt=\"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646\" class=\"wp-image-4526\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg 847w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-248x300.jpg 248w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-768x929.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1270x1536.jpg 1270w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1693x2048.jpg 1693w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-10x12.jpg 10w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-347x420.jpg 347w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-150x181.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-300x363.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-696x842.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1068x1292.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1920x2323.jpg 1920w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping.jpg 1984w\" sizes=\"auto, (max-width: 847px) 100vw, 847px\" \/><figcaption class=\"wp-element-caption\"><a href=\"https:\/\/dmdwarrior.com\/ar\/mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/a><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062c\u0631\u0628 \u0627\u0644\u0622\u0646:<\/strong> <strong><a href=\"https:\/\/dmdwarrior.com\/ar\/duchenne-exon-deletion-tool\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0647\u0644 \u0647\u0648 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0623\u0645 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0628\u0646\u064a\u0648\u064a\u061f \u0623\u062f\u0627\u0629 \u0641\u062d\u0635 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a<\/a><\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"how-the-forzetto-phase-3-trial-will-work\" class=\"wp-block-heading\">\u0643\u064a\u0641 \u0633\u062a\u0639\u0645\u0644 \u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 FORZETTO<\/h2>\n\n\n\n<h3 id=\"global-randomized-placebo-controlled-study\" class=\"wp-block-heading\">\u062f\u0631\u0627\u0633\u0629 \u0639\u0627\u0644\u0645\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0636\u0628\u0648\u0637\u0629 \u0628\u0627\u0644\u063a\u0641\u0644<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0625\u0646 \u062a\u062c\u0631\u0628\u0629 DYNE-251 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 3 FORZETTO \u0647\u064a \u062f\u0631\u0627\u0633\u0629 \u0639\u0627\u0644\u0645\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0648\u0647\u0645\u064a \u0645\u0635\u0645\u0645\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0633\u0644\u0627\u0645\u0629 \u0648\u0641\u0639\u0627\u0644\u064a\u0629 z-rostudirsen.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u0627 \u064a\u0644\u064a:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062d\u0648\u0627\u0644\u064a 90 \u0645\u0634\u0627\u0631\u0643\u064b\u0627 \u0645\u0646 \u0627\u0644\u0630\u0643\u0648\u0631 \u0627\u0644\u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u064a<\/li>\n\n\n\n<li>\u0645\u0646 \u0633\u0646 4 \u0625\u0644\u0649 18 \u0633\u0646\u0629<\/li>\n\n\n\n<li>\u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0648\u0646 \u0639\u0644\u0649 \u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/li>\n\n\n\n<li>\u0633\u064a\u062a\u0644\u0642\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0623\u062d\u062f \u0627\u0644\u062e\u064a\u0627\u0631\u064a\u0646 \u0627\u0644\u062a\u0627\u0644\u064a\u064a\u0646:\n<ul class=\"wp-block-list\">\n<li>20 \u0645\u0644\u063a\/\u0643\u063a \u0632-\u0631\u0648\u0633\u062a\u0648\u062f\u064a\u0631\u0633\u0646<\/li>\n\n\n\n<li>\u0623\u0648 \u062f\u0648\u0627\u0621 \u0648\u0647\u0645\u064a<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u0633\u064a\u062a\u0645 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0643\u0644 \u0623\u0631\u0628\u0639\u0629 \u0623\u0633\u0627\u0628\u064a\u0639 (Q4W)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0645 \u0628\u0627\u0644\u0641\u0639\u0644 \u062a\u0641\u0639\u064a\u0644 \u0623\u0648\u0644 \u0645\u0648\u0642\u0639 \u0644\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0648\u0627\u0644\u062a\u0633\u062c\u064a\u0644 \u0645\u0641\u062a\u0648\u062d \u0627\u0644\u0622\u0646.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"primary-endpoint-focuses-on-muscle-function\" class=\"wp-block-heading\">\u062a\u0631\u0643\u0632 \u0646\u0642\u0637\u0629 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0639\u0644\u0649 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a<\/h2>\n\n\n\n<h3 id=\"rise-from-floor-velocity-will-be-measured\" class=\"wp-block-heading\">\u0633\u064a\u062a\u0645 \u0642\u064a\u0627\u0633 \u0633\u0631\u0639\u0629 \u0627\u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0645\u0646 \u0627\u0644\u0623\u0631\u0636\u064a\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0647\u0648 \u0642\u064a\u0627\u0633 \u0627\u0644\u062a\u063a\u064a\u0631\u0627\u062a \u0641\u064a \u0633\u0631\u0639\u0629 \u0627\u0644\u0646\u0647\u0648\u0636 \u0645\u0646 \u0627\u0644\u0623\u0631\u0636 (RFF)\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0633\u0645\u0649 \u0623\u064a\u0636\u064b\u0627 \u0633\u0631\u0639\u0629 \u0648\u0642\u062a \u0627\u0644\u0646\u0647\u0648\u0636 (TTR)\u060c \u0641\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639 73.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0642\u064a\u0633 \u0647\u0630\u0627 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0645\u062f\u0649 \u0633\u0631\u0639\u0629 \u0642\u062f\u0631\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0639\u0644\u0649 \u0627\u0644\u0646\u0647\u0648\u0636 \u0645\u0646 \u0627\u0644\u0623\u0631\u0636 \u0648\u064a\u0639\u062a\u0628\u0631 \u0645\u0624\u0634\u0631\u0627\u064b \u0645\u0647\u0645\u0627\u064b \u0644\u0642\u0648\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0644\u062a\u0646\u0633\u064a\u0642 \u0627\u0644\u062d\u0631\u0643\u064a \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 1\/2 \u0627\u0644\u0633\u0627\u0628\u0642\u0629 DELIVER\u060c \u0623\u0638\u0647\u0631 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0639\u0648\u0644\u062c\u0648\u0627 \u0628\u0640 z-rostudirsen \u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0643\u0628\u064a\u0631\u0629 \u0641\u064a \u0633\u0631\u0639\u0629 RFF \u0628\u0639\u062f \u0633\u062a\u0629 \u0623\u0634\u0647\u0631 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0639\u0648\u0644\u062c\u0648\u0627 \u0628\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"additional-secondary-endpoints-in-the-forzetto-study\" class=\"wp-block-heading\">\u0646\u0642\u0627\u0637 \u0627\u0644\u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u062b\u0627\u0646\u0648\u064a\u0629 \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u0629 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 FORZETTO<\/h2>\n\n\n\n<h3 id=\"researchers-will-track-mobility-and-lung-function\" class=\"wp-block-heading\">\u0633\u064a\u0642\u0648\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u062a\u062a\u0628\u0639 \u0627\u0644\u062d\u0631\u0643\u0629 \u0648\u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0631\u0626\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u062a\u0642\u064a\u0651\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0623\u064a\u0636\u0627\u064b \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0648\u0638\u064a\u0641\u064a\u0629 \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0633\u0631\u0639\u0629 \u0627\u0644\u062e\u0637\u0648\u0629 \u0639\u0646\u062f \u0627\u0644\u0645\u0626\u064a\u0646 95 (SV95C)<\/li>\n\n\n\n<li><a href=\"https:\/\/dmdwarrior.com\/ar\/north-star-ambulatory-assessment-nsaa-in-duchenne-dmd\/\" target=\"_blank\" data-type=\"post\" data-id=\"4959\" rel=\"noreferrer noopener\">\u0627\u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0625\u0633\u0639\u0627\u0641\u064a \u0644\u0646\u062c\u0645 \u0627\u0644\u0634\u0645\u0627\u0644 (NSAA)<\/a><\/li>\n\n\n\n<li>\u0627\u0644\u0645\u0634\u064a\/\u0627\u0644\u062c\u0631\u064a \u0644\u0645\u0633\u0627\u0641\u0629 10 \u0623\u0645\u062a\u0627\u0631 (10MWR)<\/li>\n\n\n\n<li>\u0635\u0639\u0648\u062f \u0623\u0631\u0628\u0639 \u062f\u0631\u062c\u0627\u062a (4SC)<\/li>\n\n\n\n<li>\u0627\u0644\u0646\u0633\u0628\u0629 \u0627\u0644\u0645\u0626\u0648\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629 \u0644\u0644\u0633\u0639\u0629 \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0627\u0644\u0642\u0633\u0631\u064a\u0629 (FVC%p)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0633\u064a\u0642\u0648\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u064a\u0636\u0627\u064b \u0628\u062c\u0645\u0639 \u0646\u062a\u0627\u0626\u062c \u0623\u0628\u0644\u063a \u0639\u0646\u0647\u0627 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0641\u0647\u0645 \u0623\u0641\u0636\u0644 \u0644\u0643\u064a\u0641\u064a\u0629 \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0644\u0649 \u0627\u0644\u062d\u064a\u0627\u0629 \u0627\u0644\u064a\u0648\u0645\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0628\u0639\u062f \u0641\u062a\u0631\u0629 \u0627\u0644\u0645\u0631\u0627\u0642\u0628\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0627\u0644\u062a\u064a \u0627\u0633\u062a\u0645\u0631\u062a 72 \u0623\u0633\u0628\u0648\u0639\u064b\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a\u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0644\u0645\u0624\u0647\u0644\u064a\u0646 \u0627\u0644\u0627\u0633\u062a\u0645\u0631\u0627\u0631 \u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u062a\u0645\u062f\u064a\u062f \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u062a\u0633\u0645\u064a\u0629 \u0644\u0645\u062f\u0629 96 \u0623\u0633\u0628\u0648\u0639\u064b\u0627.<\/strong><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"fda-alignment-and-accelerated-approval-plans\" class=\"wp-block-heading\">\u062e\u0637\u0637 \u0627\u0644\u062a\u0648\u0627\u0641\u0642 \u0648\u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0639\u062c\u0644\u0629 FDA<\/h2>\n\n\n\n<h3 id=\"forzetto-could-support-full-traditional-approval\" class=\"wp-block-heading\">\u064a\u0645\u0643\u0646 \u0644\u0640 FORZETTO \u062f\u0639\u0645 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0635\u0631\u062d\u062a \u0634\u0631\u0643\u0629 Dyne Therapeutics \u0628\u0623\u0646\u0647\u0627 \u0642\u062f \u0627\u062a\u0641\u0642\u062a \u0645\u0639 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0628\u0634\u0623\u0646 \u062a\u0635\u0645\u064a\u0645 \u0648\u0628\u0631\u0648\u062a\u0648\u0643\u0648\u0644 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 FORZETTO.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0647\u062f\u0641 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0625\u0644\u0649 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0628\u0645\u062b\u0627\u0628\u0629 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u062a\u0623\u0643\u064a\u062f\u064a\u0629 \u0627\u0644\u0644\u0627\u0632\u0645\u0629 \u0644\u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0639\u062c\u0644\u0629 \u0625\u0644\u0649 \u0645\u0648\u0627\u0641\u0642\u0629 \u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0643\u0627\u0645\u0644\u0629 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629. \u0648\u0642\u062f \u062a\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0623\u064a\u0636\u064b\u0627 \u0637\u0644\u0628\u0627\u062a \u0627\u0644\u062a\u0631\u062e\u064a\u0635 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u062e\u0627\u0631\u062c \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"why-the-dyne-therapeutics-phase-3-forzetto-trial-of-z-rostudirsen-for-dmd-matters\" class=\"wp-block-heading\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 Dyne Therapeutics FORZETTO \u0644\u0639\u0642\u0627\u0631 Z-Rostudirsen \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0645\u0647\u0645\u0629\u061f<\/h2>\n\n\n\n<h3 id=\"a-potentially-important-development-for-the-dmd-community\" class=\"wp-block-heading\">\u062a\u0637\u0648\u0631 \u0647\u0627\u0645 \u0645\u062d\u062a\u0645\u0644 \u0644\u0645\u062c\u062a\u0645\u0639 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u0645\u062b\u0644 \u0625\u0637\u0644\u0627\u0642 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u062a\u062c\u0631\u0628\u0629 Dyne Therapeutics FORZETTO \u0644\u0640 Z-Rostudirsen \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0639\u0644\u0627\u0645\u0629 \u0641\u0627\u0631\u0642\u0629 \u0645\u0647\u0645\u0629 \u0644\u0645\u062c\u062a\u0645\u0639 \u062f\u0648\u0634\u064a\u0646\u060c \u0648\u062e\u0627\u0635\u0629 \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0624\u0647\u0644\u064a\u0646 \u0644\u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0639 \u0648\u062c\u0648\u062f \u0628\u064a\u0627\u0646\u0627\u062a \u0633\u0631\u064a\u0631\u064a\u0629 \u0633\u0627\u0628\u0642\u0629 \u0648\u0627\u0639\u062f\u0629 \u0648\u062f\u0631\u0627\u0633\u0629 \u062a\u0623\u0643\u064a\u062f\u064a\u0629 \u0643\u0628\u064a\u0631\u0629 \u062c\u0627\u0631\u064a\u0629 \u0627\u0644\u0622\u0646\u060c \u0633\u064a\u0631\u0627\u0642\u0628 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0648\u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0639\u0646 \u0643\u062b\u0628 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0628\u0625\u0645\u0643\u0627\u0646 DYNE-251 \u062a\u062d\u0642\u064a\u0642 \u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0648\u0638\u064a\u0641\u064a\u0629 \u0630\u0627\u062a \u0645\u063a\u0632\u0649 \u0644\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"contact-information\" class=\"wp-block-heading\">\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0627\u062a\u0635\u0627\u0644<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0627\u0644\u0627\u0633\u0645: \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0634\u0631\u0643\u0629 \u062f\u0627\u064a\u0646<\/li>\n\n\n\n<li>\u0631\u0642\u0645 \u0627\u0644\u0647\u0627\u062a\u0641: +1-781-317-1919<\/li>\n\n\n\n<li>\u0627\u0644\u0628\u0631\u064a\u062f \u0627\u0644\u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a: clinicaltrials@dyne-tx.com<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u0627\u0628\u0639 \u0647\u0630\u0647 \u0627\u0644\u0635\u0641\u062d\u0629<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Dyne Therapeutics has announced the start of the Dyne Therapeutics Phase 3 FORZETTO Trial (NCT07608432) of Z-Rostudirsen for DMD, marking another major step forward for families affected by Duchenne muscular dystrophy (DMD). The global Phase 3 study will evaluate z-rostudirsen (DYNE-251) in people living with DMD who are amenable to exon 51 skipping. The company [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8013,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[137,143,208,145,122,193,421,194,780,460],"class_list":["post-7974","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-clinical-trial","tag-dyne","tag-dyne-therapeutics","tag-dyne-251","tag-exon-51","tag-exon-51-skipping","tag-exon-51-skipping-therapy","tag-exon-51-treatment","tag-forzetto","tag-z-rostudirsen"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/7974","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=7974"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/7974\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/8013"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=7974"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=7974"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=7974"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}