{"id":5101,"date":"2025-11-04T16:49:31","date_gmt":"2025-11-04T13:49:31","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=5101"},"modified":"2025-11-04T17:01:51","modified_gmt":"2025-11-04T14:01:51","slug":"solid-biosciences-provides-update-on-inspire-duchenne-clinical-trial-progress-and-planned-regulatory-discussions","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/solid-biosciences-provides-update-on-inspire-duchenne-clinical-trial-progress-and-planned-regulatory-discussions\/","title":{"rendered":"\u064a\u0642\u062f\u0645 Solid Biosciences \u062a\u062d\u062f\u064a\u062b\u064b\u0627 \u062d\u0648\u0644 \u062a\u0642\u062f\u0645 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 INSPIRE DUCHENNE \u0648\u0627\u0644\u0645\u0646\u0627\u0642\u0634\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0647\u0627"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Solid Biosciences \u0639\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0624\u0642\u062a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0645\u0646 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 INSPIRE DUCHENNE \u0644\u0644\u0645\u0631\u062d\u0644\u0629 1\/2.<\/strong> \u0643\u0645\u0627 \u0642\u062f\u0645\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u062a\u062d\u062f\u064a\u062b\u064b\u0627 \u0644\u0644\u062a\u0648\u0642\u064a\u062a \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0627\u062c\u062a\u0645\u0627\u0639\u0647\u0627 \u0645\u0639 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u0644\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629\u060c \u0644\u0640 SGT-003.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0639\u0644\u0642 \u0628\u0648 \u0643\u0648\u0645\u0628\u0648\u060c \u0627\u0644\u0631\u0626\u064a\u0633 \u0648\u0627\u0644\u0645\u062f\u064a\u0631 \u0627\u0644\u062a\u0646\u0641\u064a\u0630\u064a \u0644\u0634\u0631\u0643\u0629 Solid Biosciences\u060c \u0642\u0627\u0626\u0644\u0627\u064b: &quot;\u0625\u0646 \u0628\u064a\u0627\u0646\u0627\u062a INSPIRE DUCHENNE \u0627\u0644\u0645\u0624\u0642\u062a\u0629 \u0627\u0644\u062a\u064a \u0646\u064f\u0634\u0631\u062a \u0627\u0644\u064a\u0648\u0645 \u062a\u064f\u0639\u0632\u0632 \u062b\u0642\u062a\u0646\u0627 \u0628\u0627\u0644\u0642\u062f\u0631\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0640 SGT-003. \u0641\u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0642\u0648\u064a\u0629 \u0627\u0644\u0645\u064f\u0644\u0627\u062d\u064e\u0638\u0629 \u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0645\u064a\u0643\u0631\u0648\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 SGT-003 \u0645\u0639 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0645\u0631\u0643\u0628 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0645\u0648\u0636\u0639\u064a\u064b\u0627 \u0628\u0634\u0643\u0644 \u0635\u062d\u064a\u062d\u060c \u0648\u0635\u0648\u0644\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0639\u0644\u0649 \u0639\u0648\u062f\u0629 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u0642\u0644\u0628 \u0625\u0644\u0649 \u0637\u0628\u064a\u0639\u062a\u0647\u0627\u060c \u0646\u0644\u0627\u062d\u0638 \u062a\u0623\u062b\u064a\u0631\u064b\u0627 \u0648\u0627\u0636\u062d\u064b\u0627 \u0648\u0645\u062a\u062a\u0627\u0644\u064a\u064b\u0627 \u0641\u064a \u062c\u0633\u0645 \u0627\u0644\u0625\u0646\u0633\u0627\u0646\u060c \u0645\u0645\u0627 \u064a\u064f\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u062c\u0647\u0627\u0632\u064a\u0629 \u0645\u064f\u0646\u0633\u064e\u0651\u0642\u0629 \u0644\u0644\u0639\u0644\u0627\u062c. \u0646\u0639\u062a\u0642\u062f \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u0624\u0642\u062a\u0629 \u062a\u064f\u0645\u062b\u0644 \u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0627\u0644\u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0634\u0645\u0648\u0644\u064b\u0627 \u0644\u0623\u064a \u0639\u0644\u0627\u062c \u062c\u064a\u0646\u064a \u0644\u062f\u0648\u0634\u064a\u0646 \u062d\u062a\u0649 \u0627\u0644\u0622\u0646. \u0625\u0646 \u062c\u0648\u062f\u0629 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0624\u0642\u062a\u0629 \u0648\u062a\u0648\u0627\u0641\u0642\u0647\u0627 \u064a\u064f\u0639\u0632\u0632\u0627\u0646 \u0642\u0646\u0627\u0639\u062a\u0646\u0627 \u0628\u0642\u062f\u0631\u0629 SGT-003 \u0639\u0644\u0649 \u062a\u0631\u062c\u0645\u0629 \u0627\u0644\u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0625\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u0639\u0651\u0627\u0644\u0629.&quot;\u201c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u062a\u0627\u0628\u0639 \u0627\u0644\u0633\u064a\u062f \u0643\u0648\u0645\u0628\u0648 \u0642\u0627\u0626\u0644\u0627\u064b: &quot;\u0641\u064a \u0636\u0648\u0621 \u0627\u0644\u0645\u0634\u0647\u062f \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a \u0627\u0644\u0645\u062a\u0637\u0648\u0631 \u0648\u0627\u0644\u0648\u062a\u064a\u0631\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0644\u0644\u062a\u0633\u062c\u064a\u0644 \u0641\u064a INSPIRE DUCHENNE\u060c \u0627\u062a\u062e\u0630\u0646\u0627 \u0642\u0631\u0627\u0631\u064b\u0627 \u0627\u0633\u062a\u0628\u0627\u0642\u064a\u064b\u0627 \u0628\u0646\u0642\u0644 \u0627\u062c\u062a\u0645\u0627\u0639\u0646\u0627 \u0627\u0644\u0645\u062e\u0637\u0637 \u0644\u0647 \u0645\u0639 FDA \u0625\u0644\u0649 \u0627\u0644\u0646\u0635\u0641 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2026. \u0633\u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u0625\u0636\u0627\u0641\u064a \u0645\u0646 1) \u0625\u0646\u0634\u0627\u0621 \u0645\u062c\u0645\u0648\u0639\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0623\u0643\u062b\u0631 \u0634\u0645\u0648\u0644\u0627\u064b \u0644\u0644\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0639 FDA\u060c 2) \u0627\u0644\u0639\u0645\u0644 \u0639\u0644\u0649 \u0645\u0642\u0627\u0631\u0646\u0629 \u062e\u0627\u0631\u062c\u064a\u0629 \u0634\u0627\u0645\u0644\u0629 \u062a\u0633\u062a\u0646\u062f \u0625\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u0627\u0631\u064a\u062e \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u062c\u0648\u062f\u0629 \u0648\u0627\u0644\u0645\u062a\u0637\u0627\u0628\u0642\u0629 \u062c\u064a\u062f\u064b\u0627\u060c 3) \u0628\u062f\u0621 \u0639\u0645\u0644\u064a\u0627\u062a \u062a\u0635\u0646\u064a\u0639 \u062a\u0623\u0647\u064a\u0644 \u0623\u062f\u0627\u0621 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 (PPQ) \u0645\u0639 \u0634\u0631\u064a\u0643\u0646\u0627 CDMO \u0627\u0633\u062a\u0639\u062f\u0627\u062f\u064b\u0627 \u0644\u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628 \u062a\u0631\u062e\u064a\u0635 \u0628\u064a\u0648\u0644\u0648\u062c\u064a \u0645\u062d\u062a\u0645\u0644 (BLA)\u060c \u06484) \u0628\u062f\u0621 \u0627\u0644\u062c\u0631\u0639\u0627\u062a \u0641\u064a IMPACT DUCHENNE\u060c \u062a\u062c\u0631\u0628\u062a\u0646\u0627 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u0627\u0644\u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0648\u0647\u0645\u064a \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 3 \u0648\u0627\u0644\u062a\u064a \u0633\u064a\u062a\u0645 \u0625\u062c\u0631\u0627\u0624\u0647\u0627 \u062e\u0627\u0631\u062c \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629. \u0646\u0639\u062a\u0642\u062f \u0623\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u0646\u0634\u0637\u0629 \u062a\u0636\u0639 Solid \u0641\u064a \u0623\u0641\u0636\u0644 \u0648\u0636\u0639 \u0644\u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u062d\u0632\u0645\u0629 \u0627\u0644\u0623\u0643\u062b\u0631 \u0625\u0642\u0646\u0627\u0639\u064b\u0627 \u0644\u0644\u062c\u0647\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201c\u0623\u0648\u0644\u0648\u064a\u062a\u0646\u0627 \u0627\u0644\u0622\u0646 \u0647\u064a \u0628\u0646\u0627\u0621 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0642\u0648\u064a\u0629 \u0628\u0633\u0631\u0639\u0629 \u0644\u062f\u0639\u0645 \u0645\u0633\u0627\u0631 \u062a\u0646\u0638\u064a\u0645\u064a \u0645\u064f\u0633\u0631\u0651\u0639 \u0645\u064f\u062d\u062a\u0645\u0644 \u0644\u0640 SGT-003\u060c \u0648\u0646\u062d\u0646 \u0645\u0644\u062a\u0632\u0645\u0648\u0646 \u0628\u0627\u0644\u062a\u0646\u0641\u064a\u0630 \u0627\u0644\u0639\u0627\u062c\u0644 \u0644\u062a\u062d\u0642\u064a\u0642 \u0625\u0645\u0643\u0627\u0646\u0627\u062a SGT-003 \u0641\u064a \u0623\u0633\u0631\u0639 \u0648\u0642\u062a \u0645\u0645\u0643\u0646. \u0628\u0639\u062f SGT-003\u060c \u062a\u0648\u0627\u0635\u0644 \u0628\u0631\u0627\u0645\u062c\u0646\u0627 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0644\u062a\u0637\u0648\u064a\u0631 \u0627\u0644\u062a\u0642\u062f\u0645. \u0648\u0627\u062e\u062a\u062a\u0645 \u0627\u0644\u0633\u064a\u062f \u0643\u0648\u0645\u0628\u0648 \u062d\u062f\u064a\u062b\u0647.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">SGT-003 \u2013 \u062a\u062c\u0631\u0628\u0629 \u0625\u0646\u0633\u0628\u0627\u064a\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062a\u0645 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062c\u0631\u0639\u0629 \u0644\u0640 23 \u0645\u0634\u0627\u0631\u0643\u064b\u0627 \u0641\u064a \u062a\u062c\u0631\u0628\u0629 INSPIRE DUCHENNE \u0627\u0639\u062a\u0628\u0627\u0631\u064b\u0627 \u0645\u0646 31 \u0623\u0643\u062a\u0648\u0628\u0631 2025\u061b \u0648\u062a\u062a\u0648\u0642\u0639 Solid \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062c\u0631\u0639\u0629 \u0644\u0640 30 \u0645\u0634\u0627\u0631\u0643\u064b\u0627 \u0641\u064a \u0627\u0644\u0645\u062c\u0645\u0648\u0639 \u0628\u062d\u0644\u0648\u0644 \u0623\u0648\u0627\u0626\u0644 \u0639\u0627\u0645 2026\u060c \u062b\u0645 \u062a\u062e\u0637\u0637 \u0644\u0644\u0642\u0627\u0621 FDA \u0644\u0645\u0646\u0627\u0642\u0634\u0629 \u0645\u0633\u0627\u0631\u0627\u062a \u0627\u0644\u062a\u0633\u062c\u064a\u0644 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u0641\u064a \u0627\u0644\u0646\u0635\u0641 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2026 -<\/li>\n\n\n\n<li>\u062a\u0645 \u062a\u062d\u0645\u0644 SGT-003 \u0628\u0634\u0643\u0644 \u062c\u064a\u062f \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0638\u0627\u0645 \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0648\u0642\u0627\u0626\u064a \u0628\u0627\u0644\u0633\u062a\u064a\u0631\u0648\u064a\u062f \u0641\u0642\u0637\u061b \u0648\u0627\u0633\u062a\u0645\u0631\u062a \u0645\u0631\u0627\u0642\u0628\u0629 \u0633\u0644\u0627\u0645\u0629 \u0627\u0644\u0642\u0644\u0628 \u0641\u064a \u0625\u0638\u0647\u0627\u0631 \u0627\u0646\u062e\u0641\u0627\u0636 \u0641\u064a \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0625\u0634\u0627\u0631\u0627\u062a \u0645\u0628\u0643\u0631\u0629 \u0644\u062a\u0637\u0628\u064a\u0639 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0642\u0644\u0628 -<\/li>\n\n\n\n<li>\u0623\u0638\u0647\u0631\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u062e\u0632\u0639\u0629 \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0633\u0639\u064a\u0646 \u0645\u0646 10 \u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0639\u0648\u0644\u062c\u0648\u0627 (\u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0645\u0646 5 \u0625\u0644\u0649 10 \u0633\u0646\u0648\u0627\u062a) \u0623\u0646 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0648\u0627 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u0645\u062a\u0648\u0633\u0637 \u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0645\u064a\u0643\u0631\u0648\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 58% \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0646\u0642\u0644 \u0627\u0644\u063a\u0631\u0628\u064a\u060c \u064858% \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0637\u064a\u0627\u0641\u064a\u0629 \u0627\u0644\u0643\u062a\u0644\u0629\u060c \u0648\u0645\u062a\u0648\u0633\u0637 \u0623\u0644\u064a\u0627\u0641 \u0645\u064a\u0643\u0631\u0648\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 51% \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u064a\u0629\u060c \u0648\u0645\u062a\u0648\u0633\u0637 \u0623\u0644\u064a\u0627\u0641 \u0628\u064a\u062a\u0627 \u0633\u0627\u0631\u0643\u0648\u062c\u0644\u064a\u0643\u0627\u0646 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 50% \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0641\u0644\u0648\u0631\u064a\u0629 -<\/li>\n\n\n\n<li>\u0623\u0638\u0647\u0631\u062a \u0627\u0644\u0627\u0631\u062a\u0628\u0627\u0637\u0627\u062a \u0627\u0644\u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0627\u0644\u0642\u0648\u064a\u0629 \u0627\u0644\u062a\u064a \u0644\u0648\u062d\u0638\u062a \u0628\u064a\u0646 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0633\u0639\u064a\u0646 \u0648\u0627\u0644\u0645\u0643\u0648\u0646\u0627\u062a \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0645\u062c\u0645\u0639 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 (DAPC)\u060c \u0628\u064a\u062a\u0627 \u0633\u0627\u0631\u0643\u0648\u062c\u0644\u064a\u0643\u0627\u0646 (r = 0.95) \u0648nNOS (r = 0.95)\u060c \u062f\u0644\u064a\u0644\u0627\u064b \u0639\u0644\u0649 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 DAPC \u0628\u0648\u0633\u0627\u0637\u0629 SGT-003 \u0648\u0625\u0634\u0627\u0631\u0627\u062a \u0645\u062a\u0648\u0627\u0641\u0642\u0629 \u0644\u062d\u0645\u0627\u064a\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0646\u062e\u0641\u0627\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a CK (r = -0.78) -<\/li>\n\n\n\n<li>\u0642\u0627\u0645\u062a \u0634\u0631\u0643\u0629 Solid \u0628\u062a\u0646\u0634\u064a\u0637 \u0623\u0648\u0644 \u0645\u0648\u0642\u0639 \u0644\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u062a\u0642\u0648\u0645 \u062d\u0627\u0644\u064a\u064b\u0627 \u0628\u0641\u062d\u0635 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0645\u0646 \u0623\u062c\u0644 IMPACT DUCHENNE\u060c \u0648\u0647\u064a \u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u062a\u062d\u0643\u0645 \u0628\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0648\u0647\u0645\u064a \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0640 SGT-003 -<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0645 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0646\u062e\u0641\u0627\u0636\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0641\u064a \u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u0646 \u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0644\u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0646\u0647\u064a\u0627\u0631\u0647\u0627 \u062e\u0644\u0627\u0644 \u0627\u0644\u064a\u0648\u0645 90 \u0648\u0627\u0644\u064a\u0648\u0645 360:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td><strong>\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0645\u0635\u0644<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062a\u062e\u0641\u064a\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u064a\u0648\u0645 90<\/strong><br><strong>(\u0646=14 \u0645\u0627 \u0644\u0645 \u064a\u064f\u0630\u0643\u0631 \u062e\u0644\u0627\u0641 \u0630\u0644\u0643)<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u062a\u062e\u0641\u064a\u0636\u0627\u062a \u0641\u064a \u0627\u0644\u064a\u0648\u0645 360<\/strong><br><strong>(\u0646=3 \u0645\u0627 \u0644\u0645 \u064a\u064f\u0630\u0643\u0631 \u062e\u0644\u0627\u0641 \u0630\u0644\u0643)<\/strong><\/td><\/tr><tr><td>\u0643\u064a\u0646\u0627\u0632 \u0627\u0644\u0643\u0631\u064a\u0627\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0635\u0644 (CK)<\/td><td class=\"has-text-align-center\" data-align=\"center\">34%<\/td><td class=\"has-text-align-center\" data-align=\"center\">42%<\/td><\/tr><tr><td>\u0646\u0627\u0642\u0644\u0629 \u0623\u0645\u064a\u0646 \u0627\u0644\u0623\u0644\u0627\u0646\u064a\u0646 \u0641\u064a \u0627\u0644\u0645\u0635\u0644 (ALT)<\/td><td class=\"has-text-align-center\" data-align=\"center\">41%<\/td><td class=\"has-text-align-center\" data-align=\"center\">29%<\/td><\/tr><tr><td>\u0623\u0633\u0628\u0627\u0631\u062a\u0627\u062a \u0623\u0645\u064a\u0646\u0648\u062a\u0631\u0627\u0646\u0633\u0641\u064a\u0631\u0627\u0632 \u0627\u0644\u0645\u0635\u0644 (AST)<\/td><td class=\"has-text-align-center\" data-align=\"center\">25%<\/td><td class=\"has-text-align-center\" data-align=\"center\">40%<\/td><\/tr><tr><td>\u0644\u0627\u0643\u062a\u0627\u062a \u062f\u064a\u0647\u064a\u062f\u0631\u0648\u062c\u064a\u0646\u064a\u0632 \u0627\u0644\u0645\u0635\u0644 (LDH)*<\/td><td class=\"has-text-align-center\" data-align=\"center\">42%<\/td><td class=\"has-text-align-center\" data-align=\"center\">46%<\/td><\/tr><tr><td>\u062a\u064a\u062a\u064a\u0646 \u0627\u0644\u0645\u0635\u0644**<\/td><td class=\"has-text-align-center\" data-align=\"center\">22%<\/td><td class=\"has-text-align-center\" data-align=\"center\">25%<\/td><\/tr><tr><td colspan=\"3\"><em>*\u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646: 12 \u0639\u064a\u0646\u0629 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0633\u0639\u064a\u0646 \u0644\u0640 LDH (\u062a\u0645 \u062a\u062d\u0644\u064a\u0644 \u0639\u064a\u0646\u062a\u064a\u0646)\u061b **\u0639\u062f\u062f \u0627\u0644\u0639\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u0627\u062d\u0629 \u0645\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646: 11 \u0639\u064a\u0646\u0629 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u062a\u0633\u0639\u064a\u0646 \u06482 \u0639\u064a\u0646\u0629 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 360 \u0644\u0640 Titin\u060c \u0648\u0627\u0644\u0630\u064a \u062a\u0645 \u062a\u062d\u0644\u064a\u0644\u0647 \u062f\u0641\u0639\u0629 \u0648\u0627\u062d\u062f\u0629 \u0641\u064a \u062a\u0627\u0631\u064a\u062e \u0642\u0637\u0639 \u0633\u0627\u0628\u0642.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u062a\u0623\u062b\u064a\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 3<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0641\u064a \u0623\u0643\u062a\u0648\u0628\u0631 2025\u060c \u0641\u0639\u0651\u0644\u062a \u0634\u0631\u0643\u0629 Solid \u0623\u0648\u0644 \u0645\u0648\u0642\u0639 \u0644\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0628\u062f\u0623\u062a \u0641\u062d\u0635 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u062a\u062c\u0631\u0628\u0629 IMPACT DUCHENNE\u060c \u0648\u0647\u064a \u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0639\u0634\u0648\u0627\u0626\u064a\u0629 \u0645\u0632\u062f\u0648\u062c\u0629 \u0627\u0644\u062a\u0639\u0645\u064a\u0629 \u0648\u062e\u0627\u0636\u0639\u0629 \u0644\u0644\u062a\u062d\u0643\u0645 \u0627\u0644\u0648\u0647\u0645\u064a \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 SGT-003. \u0633\u062a\u064f\u062c\u0631\u0649 \u062a\u062c\u0631\u0628\u0629 IMPACT DUCHENNE \u0639\u0644\u0649 \u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0645\u0646 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u062e\u0627\u0631\u062c \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629\u060c \u0648\u0642\u062f \u0635\u064f\u0645\u0645\u062a \u0644\u062f\u0639\u0645 \u0627\u0644\u062a\u0631\u0627\u062e\u064a\u0635 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0629 \u062e\u0627\u0631\u062c \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629. \u0648\u0642\u062f \u062d\u0635\u0644\u0646\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629 \u0644\u0625\u062c\u0631\u0627\u0621 \u062a\u062c\u0631\u0628\u0629 IMPACT DUCHENNE \u0641\u064a \u0643\u0644 \u0645\u0646 \u0643\u0646\u062f\u0627 \u0648\u0623\u0633\u062a\u0631\u0627\u0644\u064a\u0627\u060c \u0648\u0646\u062e\u0637\u0637 \u0644\u062a\u0648\u0633\u064a\u0639 \u0646\u0637\u0627\u0642 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0644\u062a\u0634\u0645\u0644 \u062f\u0648\u0644\u064b\u0627 \u0623\u062e\u0631\u0649\u060c \u0631\u0647\u0646\u064b\u0627 \u0628\u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0627\u062a \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629. <a href=\"https:\/\/dmdwarrior.com\/ar\/solid-biosciences-sgt-003-gene-therapy-phase-3-clinical-trial-nct07160634\/\" target=\"_blank\" rel=\"noreferrer noopener\">(IMPACT DUCHENNE)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u0627\u0628\u0639 \u0647\u0630\u0647 \u0627\u0644\u0635\u0641\u062d\u0629<\/strong>&nbsp;&gt;&gt;&gt;&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u062c\u0645\u064a\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Solid Biosciences announced positive new interim data from the Phase 1\/2 INSPIRE DUCHENNE clinical trial. The Company also provided an update to the planned timing of its meeting with the U.S. Food and Drug Administration (FDA) to discuss potential registrational pathways, including accelerated approval pathways, for SGT-003. Bo Cumbo, President and CEO of Solid Biosciences [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5102,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[61,110,170,109],"class_list":["post-5101","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-gene-therapy","tag-sgt-003","tag-sgt-003-gene-therapy","tag-solid-biosciences"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/5101","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=5101"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/5101\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/5102"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=5101"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=5101"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=5101"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}