{"id":4953,"date":"2025-10-30T11:58:41","date_gmt":"2025-10-30T08:58:41","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4953"},"modified":"2025-10-30T11:58:42","modified_gmt":"2025-10-30T08:58:42","slug":"hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/hansa-imlifidase-reduce-anti-aav-antibodies-and-allow-administration-of-gene-therapy\/","title":{"rendered":"\u0647\u0627\u0646\u0632\u0627 \u0625\u0645\u0644\u064a\u0641\u064a\u062f\u064a\u0632 \u062a\u0642\u0644\u0644 \u0645\u0646 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0648\u062a\u0633\u0645\u062d \u0628\u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a"},"content":{"rendered":"<p class=\"wp-block-paragraph\">SRP-9001-104 \u0641\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 (DMD): \u062a\u0645 \u0627\u0644\u0625\u0628\u0644\u0627\u063a \u0639\u0646 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0644\u062b\u0644\u0627\u062b\u0629 \u0645\u0631\u0636\u0649 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 \u0648\u0639\u0648\u0644\u062c\u0648\u0627 \u0628\u0625\u064a\u0645\u0644\u064a\u0641\u064a\u062f\u064a\u0632 \u0642\u0628\u0644 \u0625\u0639\u0637\u0627\u0621 ELEVIDYS \u0645\u0646 \u0634\u0631\u0643\u0629 Sarepta \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u062f\u0639\u0645 \u062a\u062c\u0631\u0628\u062a\u0627\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a\u060c \u0648\u0627\u062d\u062f\u0629 \u0628\u0631\u0639\u0627\u064a\u0629 \u0634\u0631\u0643\u0629 Sarepta \u0648\u0627\u0644\u0623\u062e\u0631\u0649 \u0628\u0631\u0639\u0627\u064a\u0629 \u0634\u0631\u0643\u0629 Genethon\u060c \u0642\u062f\u0631\u0629 \u0625\u064a\u0645\u0644\u064a\u0641\u064a\u062f\u0627\u0632 \u0639\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0640 AAV \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0644\u0644\u0633\u0645\u0627\u062d \u0628\u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u0642\u062f \u0644\u0627 \u062a\u0634\u0643\u0644 \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0644\u0640 AAV \u0639\u0627\u0626\u0642\u064b\u0627 \u0623\u0645\u0627\u0645 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u0639\u062f \u062c\u0631\u0639\u0629 \u0648\u0627\u062d\u062f\u0629 \u0645\u0646 \u0625\u064a\u0645\u0644\u064a\u0641\u064a\u062f\u0627\u0632\u060c \u0634\u0647\u062f \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0646\u062e\u0641\u0627\u0636\u064b\u0627 \u0633\u0631\u064a\u0639\u064b\u0627 \u0641\u064a \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 IgG\u060c \u0644\u062a\u0635\u0644 \u0625\u0644\u0649 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u226595% \u0623\u0642\u0644 \u0645\u0646 \u062e\u0637 \u0627\u0644\u0623\u0633\u0627\u0633. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643\u060c \u0627\u0646\u062e\u0641\u0636\u062a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 (AAV) \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0645\u0633\u0628\u0642\u064b\u0627 \u0625\u0644\u0649 \u0623\u0642\u0644 \u0645\u0646 1:400\u060c \u0645\u0645\u0627 \u0623\u062a\u0627\u062d \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u062f\u0648\u0627\u0621 \u0625\u064a\u0644\u064a\u0641\u064a\u062f\u064a\u0632. \u0644\u0645 \u062a\u064f\u0644\u0627\u062d\u0638 \u0623\u064a \u0645\u0624\u0634\u0631\u0627\u062a \u0633\u0644\u0627\u0645\u0629 \u062c\u062f\u064a\u062f\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629. \u062a\u062f\u0639\u0645 \u0647\u0630\u0647 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0623\u0648\u0644\u064a\u0629 \u0642\u062f\u0631\u0629 \u0625\u064a\u0645\u0644\u064a\u0641\u064a\u062f\u0627\u0632 \u0639\u0644\u0649 \u062e\u0641\u0636 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0623\u062c\u0633\u0627\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u062f\u0631\u0642\u064a\u0629 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629. <a href=\"https:\/\/dmdwarrior.com\/ar\/high-anti-aav-antibodies-may-not-prevent-elevidys-administration\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0625\u064a\u0645\u0644\u064a\u0641\u064a\u062f\u0627\u0632<\/a>.<\/p>","protected":false},"excerpt":{"rendered":"<p>SRP-9001-104 in Duchenne muscular dystrophy (DMD): Topline results were reported for three patients with DMD treated with imlifidase prior to administration of Sarepta&#8217;s ELEVIDYS in the trial. Two gene therapy trials, one sponsored by Sarepta and the other sponsored by Genethon, support the ability of imlifidase to substantially reduce anti-AAV antibodies to allow administration of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4954,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[368,448,61,401],"class_list":["post-4953","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-aav-based-gene-therapy","tag-anti-aav","tag-gene-therapy","tag-hansa-biopharma"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=4953"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4953\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/4954"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=4953"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=4953"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=4953"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}