{"id":4576,"date":"2025-09-25T16:23:32","date_gmt":"2025-09-25T13:23:32","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4576"},"modified":"2025-09-25T16:23:33","modified_gmt":"2025-09-25T13:23:33","slug":"spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/spot-mrna03-gene-therapy-early-phase-1-clinical-trial-nct07188012\/","title":{"rendered":"\u0628\u062f\u0621 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03 \u0644\u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 (NCT07188012) \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03 \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 (DMD) \u0627\u0644\u062a\u064a \u0637\u0648\u0631\u062a\u0647\u0627 \u0634\u0631\u0643\u0629 Shanghai Siponuoyin Biotechnology \u0647\u064a \u062f\u0631\u0627\u0633\u0629 \u062a\u062c\u0631\u064a\u0628\u064a\u0629 \u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u062a\u0639\u0628\u064a\u0631 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0641\u064a \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0647\u064a\u0643\u0644\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u0625\u0639\u0637\u0627\u0621.<\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-is-spot-m-rna-03-gene-therapy\">\u0645\u0627 \u0647\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03<\/a><\/li><li><a href=\"#spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\">\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 1 \u2013 NCT07188012<\/a><\/li><li><a href=\"#how-to-participate-in-the-sgt-003-clinical-trial\">\u0643\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 SPOT-mRNA03<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-spot-m-rna-03-gene-therapy\"><strong>\u0645\u0627 \u0647\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>SPOT-mRNA03 \u0647\u0648 \u0645\u0646\u062a\u062c \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 (DMD).<\/strong> \u0628\u0639\u062f \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u062f\u0648\u0627\u0621 \u0644\u0645\u0631\u0636\u0649 \u062f\u0648\u0634\u064a\u0646\u060c \u064a\u0645\u0643\u0646 \u0644\u0644\u0628\u0628\u062a\u064a\u062f \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u062c\u0632\u064a\u0626\u064a \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u063a\u0634\u0627\u0621 \u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u0629 \u062a\u0648\u062c\u064a\u0647 SPOT-mRNA03 \u0625\u0644\u0649 \u062e\u0644\u0627\u064a\u0627 \u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u064a\u0636\u060c \u0645\u0645\u0627 \u064a\u062a\u064a\u062d \u062a\u0631\u062c\u0645\u0629 \u0648\u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0627\u0644\u0633\u0644\u064a\u0645 \u0643\u0627\u0645\u0644 \u0627\u0644\u0637\u0648\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u062e\u0644\u0627\u064a\u0627 \u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0627\u0644\u0646\u0627\u0642\u0635\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0631\u064a\u0628\u0648\u0633\u0648\u0645\u0627\u062a \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0627\u0644\u0623\u062d\u0645\u0627\u0636 \u0627\u0644\u0623\u0645\u064a\u0646\u064a\u0629.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"spot-m-rna-03-gene-therapy-early-phase-1-nct-07188012\"><strong>\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a SPOT-mRNA03 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 1 \u2013 NCT07188012<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0647\u0630\u0647 \u062f\u0631\u0627\u0633\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0633\u062a\u0643\u0634\u0627\u0641\u064a\u0629 \u0623\u062d\u0627\u062f\u064a\u0629 \u0627\u0644\u0630\u0631\u0627\u0639\u060c \u0645\u0641\u062a\u0648\u062d\u0629 \u0627\u0644\u062a\u0633\u0645\u064a\u0629\u060c FIH\u060c \u0623\u062d\u0627\u062f\u064a\u0629 \u0627\u0644\u0645\u0631\u0643\u0632\u060c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 SPOT-mRNA03 \u064a\u064f\u0639\u0637\u0649 \u0648\u0631\u064a\u062f\u064a\u064b\u0627 \u0644\u0645\u0631\u0636\u0649 \u062f\u0648\u0634\u064a\u0646. \u064a\u0648\u062c\u062f \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0631\u0633\u0627\u0644 \u0643\u0627\u0645\u0644 \u0627\u0644\u0637\u0648\u0644 \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0641\u064a \u062d\u0648\u064a\u0635\u0644\u0627\u062a \u062e\u0627\u0631\u062c \u062e\u0644\u0648\u064a\u0629 (EVs) \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0644\u0639\u0636\u0644\u0627\u062a \u062a\u064f\u0633\u0645\u0649 SPOT-mRNA03. \u062a\u064f\u0639\u0637\u064a \u0628\u0628\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 \u063a\u0634\u0627\u0621 \u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629 \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 SPOT-mRNA03 \u0642\u062f\u0631\u062a\u0647 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0647\u062f\u0627\u0641\u060c \u0645\u0645\u0627 \u064a\u064f\u0645\u0643\u0651\u0646 \u0645\u0646 \u062a\u0648\u0632\u064a\u0639 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u0631\u0633\u0627\u0644 \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0643\u0645\u0646\u062a\u062c \u0639\u0644\u0627\u062c \u062c\u064a\u0646\u064a \u0644\u062f\u0648\u0634\u064a\u0646.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0628\u062f\u0621 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 (\u0645\u0642\u062f\u0631)<\/strong>: 2025-08-06<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0644\u0627\u0646\u062a\u0647\u0627\u0621 \u0627\u0644\u0623\u0648\u0644\u064a (\u062a\u0642\u062f\u064a\u0631\u064a)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0625\u0643\u0645\u0627\u0644 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 (\u062a\u0642\u062f\u064a\u0631\u064a)<\/strong>: 2026-12<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0639\u062f\u062f \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 (\u062a\u0642\u062f\u064a\u0631\u064a)<\/strong>: 6<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0646\u0648\u0639 \u0627\u0644\u062f\u0631\u0627\u0633\u0629<\/strong>:\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0645\u0648\u0642\u0639<\/strong>: <a href=\"https:\/\/maps.app.goo.gl\/Z2CyEqLydJ4Kxh9aA\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0631\u0643\u0632 \u0634\u0646\u063a\u0647\u0627\u064a \u0627\u0644\u0637\u0628\u064a \u0644\u0644\u0623\u0637\u0641\u0627\u0644<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0644\u0623\u0639\u0645\u0627\u0631 \u0627\u0644\u0645\u0624\u0647\u0644\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629<\/strong>: \u0645\u0646 \u0633\u0646\u062a\u064a\u0646 \u0625\u0644\u0649 6 \u0633\u0646\u0648\u0627\u062a (\u0630\u0643\u0648\u0631 \u0642\u0627\u062f\u0631\u064a\u0646 \u0639\u0644\u0649 \u0627\u0644\u062d\u0631\u0643\u0629)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0625\u062f\u0631\u0627\u062c \u0648\u0627\u0644\u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629. <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT07188012\" target=\"_blank\" rel=\"noreferrer noopener\">NCT07188012<\/a> -<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-to-participate-in-the-sgt-003-clinical-trial\"><strong>\u0643\u064a\u0641\u064a\u0629 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 SPOT-mRNA03<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646 SPOT-mRNA03\u060c \u064a\u0645\u0643\u0646\u0643 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0627\u062a\u0635\u0627\u0644 \u0623\u062f\u0646\u0627\u0647.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0633\u0645<\/strong>: \u0648\u064a\u0646\u0633\u062a\u0648\u0646 \u062a\u0627\u0648\u0646<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0631\u0642\u0645 \u0627\u0644\u062a\u0644\u064a\u0641\u0648\u0646<\/strong>: 212-920-5501<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0628\u0631\u064a\u062f \u0625\u0644\u0643\u062a\u0631\u0648\u0646\u064a<\/strong>: Winston.town@spotbiosystems.com<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>The early phase 1 study (NCT07188012) of SPOT-mRNA03 gene therapy for Duchenne Muscular Dystrophy (DMD) developed by Shanghai Siponuoyin Biotechnology is a pilot study of the safety and expression of dystrophin in skeletal muscles after administration. What is SPOT-mRNA03 Gene Therapy SPOT-mRNA03 is the gene therapy product for Duchenne Muscular Dystrophy (DMD). Following administration to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4580,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[123,137,242,359,61,424,423,425],"class_list":["post-4576","post","type-post","status-publish","format-standard","has-post-thumbnail","category-research","tag-china","tag-clinical-trial","tag-clinical-trials","tag-full-length-dystrophin","tag-gene-therapy","tag-shanghai-siponuoyin","tag-spot-mrna03","tag-spot-mrna03-gene-therapy"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4576","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=4576"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4576\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/4580"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=4576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=4576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=4576"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}