{"id":4518,"date":"2025-09-19T16:43:25","date_gmt":"2025-09-19T13:43:25","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4518"},"modified":"2025-09-19T16:43:27","modified_gmt":"2025-09-19T13:43:27","slug":"mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/mutations-and-deletions-amenable-to-exon-51-skipping-therapies-dmd\/","title":{"rendered":"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (DMD) \u0647\u0648 \u0627\u0636\u0637\u0631\u0627\u0628 \u0648\u0631\u0627\u062b\u064a \u062d\u0627\u062f \u0646\u0627\u062a\u062c \u0639\u0646 \u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 DMD\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u063a\u064a\u0627\u0628 \u0623\u0648 \u0634\u0628\u0647 \u063a\u064a\u0627\u0628 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0648\u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u0623\u0633\u0627\u0633\u064a \u0644\u0642\u0648\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0627\u0633\u062a\u0642\u0631\u0627\u0631\u0647\u0627. \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0628\u0639\u0636 \u0627\u0644\u0623\u0641\u0631\u0627\u062f\u060c \u062a\u064f\u0642\u062f\u0645 \u0639\u0644\u0627\u062c\u0627\u062a \u0648\u0627\u0639\u062f\u0629\u060c \u0645\u062b\u0644 \u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u060c \u0623\u0645\u0644\u0627\u064b - \u0648\u062e\u0627\u0635\u0629\u064b \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u0648\u0647\u0648 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0623\u0643\u062b\u0631 \u0627\u0633\u062a\u0647\u062f\u0627\u0641\u064b\u0627 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u0629. <strong>\u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0645\u0642\u0627\u0644\u0629\u060c \u0646\u0633\u062a\u0643\u0634\u0641 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0648\u0643\u064a\u0641\u064a\u0629 \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0642\u062f \u064a\u0633\u062a\u0641\u064a\u062f \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c.<\/strong><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-is-exon-51-skipping-therapy\">\u0645\u0627 \u0647\u064a \u0645\u0639\u0627\u0644\u062c\u0629 \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51\u061f<\/a><ul><li><a href=\"#approved-exon-51-skipping-therapy\">\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0644\u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51<\/a><\/li><\/ul><\/li><li><a href=\"#why-is-exon-51-important-in-dmd\">\u0644\u0645\u0627\u0630\u0627 \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u061f<\/a><\/li><li><a href=\"#deletions-amenable-for-exon-44-skipping\">\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062e\u0637\u064a \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/a><ul><li><a href=\"#common-deletions-amenable-to-exon-51-skipping\">\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/a><\/li><\/ul><\/li><li><a href=\"#mutations-amenable-to-exon-44-skipping\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/a><\/li><li><a href=\"#potential-benefits-of-exon-44-skipping-for-dmd-patients\">\u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51: \u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062a\u0648\u0642\u0639\u0647<\/a><\/li><li><a href=\"#summary-is-your-child-a-candidate-for-exon-51-skipping\">\u0645\u0644\u062e\u0635: \u0647\u0644 \u0637\u0641\u0644\u0643 \u0645\u0631\u0634\u062d \u0644\u062a\u062e\u0637\u064a Exon 51\u061f<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-is-exon-51-skipping-therapy\">\u0645\u0627 \u0647\u064a \u0645\u0639\u0627\u0644\u062c\u0629 \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0647\u0648 \u0646\u0647\u062c\u064c \u0637\u0628\u064a\u064c\u0651 \u062f\u0642\u064a\u0642\u064c \u064a\u0633\u062a\u062e\u062f\u0645 \u062c\u0632\u064a\u0626\u0627\u062a\u064d \u0627\u0635\u0637\u0646\u0627\u0639\u064a\u0629\u064b (\u062a\u064f\u0633\u0645\u0649 \u0623\u0648\u0644\u064a\u062c\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a\u064d \u0645\u0636\u0627\u062f\u0629\u064b \u0644\u0644\u0627\u062a\u062c\u0627\u0647) \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0623\u062b\u0646\u0627\u0621 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 (mRNA) \u0644\u062c\u064a\u0646 \u062f\u0648\u0634\u064a\u0646. \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u064a\u064f\u0645\u0643\u0646 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u062c\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0644\u0644\u062c\u0633\u0645 \u0628\u0625\u0646\u062a\u0627\u062c \u0646\u0633\u062e\u0629\u064d \u0623\u0642\u0635\u0631 \u0648\u0644\u0643\u0646\u0647\u0627 \u0641\u0639\u0627\u0644\u0629 \u0645\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"approved-exon-51-skipping-therapy\">\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0639\u062a\u0645\u062f \u0644\u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Eteplirsen (Exondys 51)<\/strong> - \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 FDA \u0644\u0639\u0644\u0627\u062c \u0645\u0631\u0636\u0649 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-is-exon-51-important-in-dmd\">\u0644\u0645\u0627\u0630\u0627 \u064a\u0639\u062a\u0628\u0631 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062d\u0648\u0627\u0644\u064a 13% \u0645\u0646 \u0645\u0631\u0636\u0649 \u062f\u0648\u0634\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0637\u0641\u0631\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u0645\u0645\u0627 \u064a\u062c\u0639\u0644\u0647 \u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0623\u0643\u062b\u0631 \u0634\u064a\u0648\u0639\u064b\u0627 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0641\u064a \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u0629. \u0647\u0630\u0627 \u064a\u062c\u0639\u0644\u0647 \u0630\u0627 \u0623\u0647\u0645\u064a\u0629 \u0628\u0627\u0644\u063a\u0629 \u0644\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0628\u062d\u062b \u0639\u0646 \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u062a\u0637\u0648\u0631\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"deletions-amenable-for-exon-44-skipping\">\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062e\u0637\u064a \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u0645\u062b\u0644 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0633\u062a\u0647\u062f\u0641\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0631\u0639\u064a\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u060c \u0648\u062e\u0627\u0635\u0629 \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0630\u064a \u064a\u062a\u0636\u0645\u0646 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a<\/strong>: 3-50, 4-50, 5-50, 6-50, 9-50, 10-50, 11-50, 13-50, 14-50, 15-50, 16-50, 17-50, 19-50, 21-50, 23-50, 24-50, 25-50, 26-50, 27-50, 28-50, 29-50,  30-50, 31-50, 32-50, 33-50, 34-50, 35-50, 36-50, 37-50, 38-50, 39-50, 40-50, 41-50, 42-50, 43-50, 45-50, 47-50, 48-50, 49-50, 50, 52, 52-61, 52-63, 52-64, 52-66, 52-76.<\/p>\n\n\n\n<div><a href=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg\" class=\"td-modal-image\"><figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"847\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg\" alt=\"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646\" class=\"wp-image-4526\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-847x1024.jpg 847w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-248x300.jpg 248w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-768x929.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1270x1536.jpg 1270w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1693x2048.jpg 1693w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-10x12.jpg 10w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-347x420.jpg 347w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-150x181.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-300x363.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-696x842.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1068x1292.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping-1920x2323.jpg 1920w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/amenable-to-exon-51-skipping.jpg 1984w\" sizes=\"(max-width: 847px) 100vw, 847px\" \/><\/figure><\/a><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/dmdwarrior.com\/ar\/duchenne-exon-deletion-tool\/\">\u0627\u0643\u062a\u0634\u0641 \u0623\u062f\u0627\u0629 \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0644\u062f\u064a\u0646\u0627<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0644\u0643\u064a \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0631\u064a\u0636 \u0645\u0631\u0634\u062d\u064b\u0627 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u062f\u064a\u0647 \u062d\u0630\u0641 \u0625\u0637\u0627\u0631\u064a \u064a\u0645\u0643\u0646 \u062a\u0635\u062d\u064a\u062d\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51. \u0648\u0627\u0644\u0647\u062f\u0641 \u0647\u0648 \u0625\u0639\u0627\u062f\u0629 \u062c\u064a\u0646 DMD \u0625\u0644\u0649 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0635\u062d\u064a\u062d.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"common-deletions-amenable-to-exon-51-skipping\">\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0630\u0627 \u0623\u0638\u0647\u0631 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0623\u062d\u062f \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u062a\u0627\u0644\u064a\u060c \u0641\u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0642\u0627\u0628\u0644\u0627\u064b \u0644\u0644\u062a\u0637\u0628\u064a\u0642:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 48-50<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 47-50<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 49-50<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 52<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 52-63<\/li>\n\n\n\n<li>\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 45-50 (\u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u062d\u0633\u0628 \u062d\u0627\u0644\u0629 \u0627\u0644\u0625\u0637\u0627\u0631)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0624\u062f\u064a \u0647\u0630\u0647 \u0627\u0644\u062d\u0630\u0641\u0627\u062a \u0625\u0644\u0649 \u062a\u0639\u0637\u064a\u0644 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0628\u0637\u0631\u064a\u0642\u0629 \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u0639\u0627\u062f\u062a\u0647\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u0638\u064a\u0641\u064a.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"mutations-amenable-to-exon-44-skipping\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0627\u0644\u062a\u0627\u0644\u064a\u0629<\/strong>: 3-50, 4-50, 5-50, 6-50, 9-50, 10-50, 11-50, 13-50, 14-50, 15-50, 16-50, 17-50, 19-50, 21-50, 23-50, 24-50, 25-50, 26-50, 27-50, 28-50, 29-50,  30-50, 31-50, 32-50, 33-50, 34-50, 35-50, 36-50, 37-50, 38-50, 39-50, 40-50, 41-50, 42-50, 43-50, 45-50, 47-50, 48-50, 49-50, 50, 52, 52-61, 52-63, 52-64, 52-66, 52-76.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"potential-benefits-of-exon-44-skipping-for-dmd-patients\">\u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51: \u0645\u0627 \u0627\u0644\u0630\u064a \u064a\u0645\u0643\u0646 \u062a\u0648\u0642\u0639\u0647<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0630\u0627 \u0643\u0627\u0646 \u0637\u0641\u0644\u0643 \u0645\u0624\u0647\u0644\u0627\u064b\u060c \u0641\u0642\u062f \u064a\u0643\u0648\u0646 \u0625\u064a\u062a\u064a\u0628\u0644\u064a\u0631\u0633\u064a\u0646 \u062e\u064a\u0627\u0631\u064b\u0627 \u0645\u0646\u0627\u0633\u0628\u064b\u0627. \u064a\u064f\u0639\u0637\u0649 \u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0644\u062d\u0642\u0646 \u0627\u0644\u0648\u0631\u064a\u062f\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639\u064a\u060c \u0648\u0647\u0648 \u0645\u0635\u0645\u0645 \u0644\u0625\u0628\u0637\u0627\u0621 \u062a\u0637\u0648\u0631 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0641\u0648\u0627\u0626\u062f:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0628\u0634\u0643\u0644 \u0623\u0628\u0637\u0623<\/li>\n\n\n\n<li>\u062a\u062d\u0633\u064a\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646<\/li>\n\n\n\n<li>\u0627\u0644\u062d\u0641\u0627\u0638 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0639\u0644\u0649 \u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u064a \u0648\u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0631\u0626\u0629<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0644\u0642\u064a\u0648\u062f:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0647\u0630\u0627 \u0644\u064a\u0633 \u0639\u0644\u0627\u062c\u064b\u0627\u060c \u0628\u0644 \u0647\u0648 \u0639\u0644\u0627\u062c \u0644\u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u0645\u0631\u0636.<\/li>\n\n\n\n<li>\u064a\u0639\u0645\u0644 \u0641\u0642\u0637 \u0639\u0644\u0649 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/li>\n\n\n\n<li>\u064a\u062a\u0637\u0644\u0628 \u0627\u0644\u062a\u0632\u0627\u0645\u064b\u0627 \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0648\u0645\u062a\u0627\u0628\u0639\u0629 \u0645\u0646\u062a\u0638\u0645\u0629.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"summary-is-your-child-a-candidate-for-exon-51-skipping\">\u0645\u0644\u062e\u0635: \u0647\u0644 \u0637\u0641\u0644\u0643 \u0645\u0631\u0634\u062d \u0644\u062a\u062e\u0637\u064a Exon 51\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0630\u0627 \u062a\u0645 \u062a\u0634\u062e\u064a\u0635 \u0637\u0641\u0644\u0643 \u0628\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646 \u0648\u0644\u062f\u064a\u0647 \u0637\u0641\u0631\u0629 \u0628\u0627\u0644\u0642\u0631\u0628 \u0645\u0646 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u060c \u0645\u062b\u0644 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0623\u0648 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 52\u060c \u0641\u0647\u0646\u0627\u0643 \u0627\u062d\u062a\u0645\u0627\u0644 \u0623\u0646 \u064a\u0633\u062a\u0641\u064a\u062f \u0645\u0646 \u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\ud83d\udd0d \u0627\u0644\u0646\u0642\u0627\u0637 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u064a\u0633\u0627\u0639\u062f \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51 \u0639\u0644\u0649 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0645\u062d\u062f\u062f\u0629.<\/li>\n\n\n\n<li>\u062d\u0648\u0627\u0644\u064a 13% \u0645\u0646 \u0645\u0631\u0636\u0649 \u062f\u0648\u0634\u064a\u0646 \u0645\u0624\u0647\u0644\u0648\u0646.<\/li>\n\n\n\n<li>\u064a\u0639\u062f \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0636\u0631\u0648\u0631\u064a\u064b\u0627 \u0644\u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u0647\u0644\u064a\u0629.<\/li>\n\n\n\n<li>\u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0645\u062b\u0644 eteplirsen FDA \u0644\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0625\u0643\u0633\u0648\u0646 51.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u062a\u0639\u0644\u0645 \u0623\u0643\u062b\u0631<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/exon-51-skipping-therapies-dmd\/\">\u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 51 \u0627\u0644\u0642\u0627\u062f\u0645\u0629 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Duchenne Muscular Dystrophy (DMD) is a severe genetic disorder caused by mutations in the DMD gene, which leads to the absence or near absence of dystrophin, a critical protein for muscle strength and stability. However, for certain individuals, promising treatments such as exon skipping therapies offer hope\u2014especially exon 51 skipping, which is the most commonly [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4524,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[122,193,421,194,77,178],"class_list":["post-4518","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dmd","tag-exon-51","tag-exon-51-skipping","tag-exon-51-skipping-therapy","tag-exon-51-treatment","tag-exon-skipping","tag-exon-skipping-therapies"],"subtitle":"\u0647\u0644 \u0627\u0628\u0646\u064a \u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u061f \u062a\u0639\u0631\u0651\u0641 \u0639\u0644\u0649 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0648\u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51. \u0645\u0627 \u0647\u064a \u062d\u0630\u0641\u0627\u062a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 51\u061f","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=4518"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4518\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/4524"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=4518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=4518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=4518"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}