{"id":4362,"date":"2025-08-25T16:43:15","date_gmt":"2025-08-25T13:43:15","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4362"},"modified":"2025-08-25T16:46:42","modified_gmt":"2025-08-25T13:46:42","slug":"duvyzat-givinostat-positive-long-term-data-from-phase-2-and-phase-3-epidys-trials","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/duvyzat-givinostat-positive-long-term-data-from-phase-2-and-phase-3-epidys-trials\/","title":{"rendered":"\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 ITF Therapeutics \u0639\u0646 \u0646\u0634\u0631 \u0628\u064a\u0627\u0646\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0645\u062f\u0649 \u062a\u064f\u0639\u0632\u0632 \u0641\u0639\u0627\u0644\u064a\u0629 \u0648\u0633\u0644\u0627\u0645\u0629 Duvyzat (Givinostat) \u0643\u0639\u0644\u0627\u062c \u0644\u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0623\u0639\u0644\u0646\u062a \u0627\u0644\u064a\u0648\u0645 \u0634\u0631\u0643\u0629 ITF Therapeutics \u0627\u0644\u062a\u0627\u0628\u0639\u0629 \u0644\u0634\u0631\u0643\u0629 Italfarmaco \u0639\u0646 \u0646\u0634\u0631 \u0628\u064a\u0627\u0646\u0627\u062a \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0637\u0648\u064a\u0644\u0629 \u0627\u0644\u0623\u0645\u062f \u062d\u0648\u0644 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0648\u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0644\u0640 Duvyzat (Givinostat) \u0643\u0639\u0644\u0627\u062c \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 (DMD) \u0645\u0646 \u0627\u0644\u062a\u0648\u0633\u0639\u0627\u062a \u0627\u0644\u0645\u0641\u062a\u0648\u062d\u0629 \u0644\u0644\u0634\u0631\u0643\u0629 \u0644\u062a\u062c\u0627\u0631\u0628\u0647\u0627 \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 (EPIDYS).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u062a\u0638\u0647\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c\u060c \u0627\u0644\u062a\u064a \u0646\u0634\u0631\u062a \u0641\u064a \u0645\u062c\u0644\u0629 Annals of Clinical and Translational Neurology\u060c \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 givinostat\u060c \u0648\u0647\u0648 \u0645\u062b\u0628\u0637 \u062c\u062f\u064a\u062f \u0644\u0625\u0646\u0632\u064a\u0645 \u0647\u064a\u0633\u062a\u0648\u0646 \u062f\u064a\u0627\u0633\u064a\u062a\u064a\u0644 (HDAC)\u060c \u0628\u0627\u0644\u0627\u0634\u062a\u0631\u0627\u0643 \u0645\u0639 \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0643\u0648\u0633\u062a\u064a\u0631\u0648\u064a\u062f\u0627\u062a\u060c \u0623\u062f\u0649 \u0625\u0644\u0649 \u062a\u0623\u062e\u064a\u0631 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u062a\u0646\u0642\u0644\u064a\u0646 \u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 \u0633\u062a \u0633\u0646\u0648\u0627\u062a \u0648\u0623\u0643\u062b\u0631 \u0648\u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u062a\u0639\u0644\u0645 \u0623\u0643\u062b\u0631<\/strong>:&nbsp;<a href=\"https:\/\/dmdwarrior.com\/ar\/duvyzat-givinostat-nonsteroidal-drug\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0627 \u0647\u0648 \u062f\u0648\u0641\u064a\u0632\u0627\u062a (\u062c\u064a\u0641\u064a\u0646\u0648\u0633\u062a\u0627\u062a)\u061f<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u0645\u0646 \u0627\u0644\u0645\u0647\u0645 \u0645\u0644\u0627\u062d\u0638\u0629 \u0641\u0627\u0626\u062f\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u062f\u0649 \u062c\u0645\u064a\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u064a \u062a\u0644\u0642\u062a \u062c\u064a\u0641\u064a\u0646\u0648\u0633\u062a\u0627\u062a\u060c \u0645\u0639 \u062a\u0623\u062b\u064a\u0631 \u0625\u064a\u062c\u0627\u0628\u064a \u0639\u0644\u0649 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062d\u0631\u0643\u0629 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629\u060c \u0645\u062b\u0644 \u0627\u0644\u0646\u0647\u0648\u0636 \u0645\u0646 \u0627\u0644\u0623\u0631\u0636\u060c \u0648\u0635\u0639\u0648\u062f \u0627\u0644\u0633\u0644\u0627\u0644\u0645\u060c \u0648\u0627\u0644\u0642\u062f\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u0645\u0634\u064a. \u0648\u0642\u062f \u062d\u0635\u0644 \u062c\u064a\u0641\u064a\u0646\u0648\u0633\u062a\u0627\u062a \u0639\u0644\u0649 \u062a\u0631\u062e\u064a\u0635 \u062a\u0633\u0648\u064a\u0642 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629\u060c \u0648\u0627\u0644\u0627\u062a\u062d\u0627\u062f \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u060c \u0648\u0627\u0644\u0645\u0645\u0644\u0643\u0629 \u0627\u0644\u0645\u062a\u062d\u062f\u0629.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0623\u0638\u0647\u0631\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0646\u0634\u0631\u062a \u0641\u064a \u0645\u062c\u0644\u0629 Annals of Clinical and Translational Neurology \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0637\u0648\u064a\u0644 \u0627\u0644\u0623\u0645\u062f \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0639\u0642\u0627\u0631 givinostat \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062e\u0631 \u0628\u0634\u0643\u0644 \u0643\u0628\u064a\u0631 \u0641\u0642\u062f\u0627\u0646 \u0648\u0638\u0627\u0626\u0641 \u0627\u0644\u062d\u0631\u0643\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062a\u0645\u062a \u0645\u0644\u0627\u062d\u0638\u0629 \u0641\u0627\u0626\u062f\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0630\u0627\u062a \u0645\u0639\u0646\u0649 \u0641\u064a \u062c\u0645\u064a\u0639 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0646 \u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u0645\u0631\u0636 \u0639\u0646\u062f \u0627\u0644\u0628\u062f\u0621.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0638\u0644 Givinostat \u062c\u064a\u062f \u0627\u0644\u062a\u062d\u0645\u0644 \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629\u060c \u0628\u0645\u0627 \u064a\u062a\u0641\u0642 \u0645\u0639 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0633\u0627\u0628\u0642\u0629.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u062a\u062c\u0627\u0648\u0632 \u0645\u062a\u0648\u0633\u0637 \u0627\u0644\u0645\u062a\u0627\u0628\u0639\u0629 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0645\u062f\u064a\u062f\u064a\u0629 36 \u0634\u0647\u0631\u064b\u0627 \u0639\u0644\u0627\u062c\u064a\u064b\u0627\u060c \u062d\u064a\u062b \u062a\u0644\u0642\u0649 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0623\u0643\u062b\u0631 \u0645\u0646 \u062b\u0645\u0627\u0646\u064a \u0633\u0646\u0648\u0627\u062a \u0645\u0646\u0630 \u0628\u062f\u0621 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0640 givinostat.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0634\u0645\u0644\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0645\u062c\u0645\u0648\u0639\u0627\u062a \u0645\u062a\u0639\u062f\u062f\u0629 \u0645\u0646 \u0627\u0644\u0635\u0628\u064a\u0629 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a (DMD)\u060c \u0648\u0627\u0644\u0630\u064a\u0646 \u062a\u0644\u0642\u0648\u0627 \u062c\u0645\u064a\u0639\u064b\u0627 \u062f\u0648\u0627\u0621 \u062c\u064a\u0641\u064a\u0646\u0648\u0633\u062a\u0627\u062a \u0644\u0641\u062a\u0631\u0627\u062a \u0632\u0645\u0646\u064a\u0629 \u0645\u062e\u062a\u0644\u0641\u0629. \u0634\u0627\u0631\u0643 \u0628\u0639\u0636\u0647\u0645 \u0633\u0627\u0628\u0642\u064b\u0627 \u0641\u064a \u062f\u0631\u0627\u0633\u0627\u062a EPIDYS \u0645\u0646 \u0627\u0644\u0645\u0631\u062d\u0644\u062a\u064a\u0646 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0648\u0627\u0644\u062b\u0627\u0644\u062b\u0629 - \u0625\u0645\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0646\u0634\u0637 \u0623\u0648 \u062f\u0648\u0627\u0621 \u0648\u0647\u0645\u064a - \u0642\u0628\u0644 \u0627\u0644\u0627\u0646\u0636\u0645\u0627\u0645 \u0625\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0645\u062f\u064a\u062f\u064a\u0629. \u0627\u0644\u062a\u062d\u0642 \u0622\u062e\u0631\u0648\u0646 \u0645\u0628\u0627\u0634\u0631\u0629\u064b \u0628\u0627\u0644\u062f\u0631\u0627\u0633\u0629 \u0627\u0644\u062a\u0645\u062f\u064a\u062f\u064a\u0629 \u0628\u0639\u062f \u0627\u0633\u062a\u064a\u0641\u0627\u0626\u0647\u0645 \u0645\u0639\u0627\u064a\u064a\u0631 \u0627\u0644\u0623\u0647\u0644\u064a\u0629\u060c \u062f\u0648\u0646 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629. \u062a\u062c\u0627\u0648\u0632 \u0625\u062c\u0645\u0627\u0644\u064a \u0645\u062f\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u062b\u0645\u0627\u0646\u064a \u0633\u0646\u0648\u0627\u062a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u062a\u0639\u0644\u0645 \u0623\u0643\u062b\u0631<\/strong>: <a href=\"https:\/\/dmdwarrior.com\/ar\/itf-therapeutics-launching-a-study-to-evaluate-the-real-world-experience-of-duvyzat-givinostat-in-patients-with-duchenne-muscular-dystrophy\/\">\u0634\u0631\u0643\u0629 ITF Therapeutics \u062a\u064f\u0637\u0644\u0642 \u062f\u0631\u0627\u0633\u0629 \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0639\u0645\u0644\u064a\u0629 \u0644\u0640 Duvyzat (Givinostat) \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>ITF Therapeutics affiliate of Italfarmaco, today announced publication of positive long-term safety and efficacy data for Duvyzat (Givinostat) as a treatment for Duchenne muscular dystrophy (DMD) from the company&#8217;s open-label extensions of its Phase 2 and Phase 3 (EPIDYS) trials. The results, published in Annals of Clinical and Translational Neurology, show that long-term treatment with [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4366,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[46,47,300],"class_list":["post-4362","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-duvyzat","tag-givinostat","tag-itf-therapeutics"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=4362"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4362\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/4366"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=4362"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=4362"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=4362"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}