{"id":4085,"date":"2026-07-28T22:48:50","date_gmt":"2026-07-28T19:48:50","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=4085"},"modified":"2026-07-28T22:48:52","modified_gmt":"2026-07-28T19:48:52","slug":"mutations-amenable-to-exon-50-skipping","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/mutations-amenable-to-exon-50-skipping\/","title":{"rendered":"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0628\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0641\u064a \u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>\u062a\u0639\u062a\u0628\u0631 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0645\u0648\u0636\u0648\u0639\u064b\u0627 \u0645\u0647\u0645\u064b\u0627 \u0641\u064a \u0623\u0628\u062d\u0627\u062b \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (DMD) \u0644\u0623\u0646 \u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0645\u0635\u0645\u0645\u0629 \u0644\u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u0639\u0637\u0644 \u0644\u062c\u064a\u0646 DMD \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u062d\u062f\u062f\u0629.<\/strong> \u0628\u062e\u0644\u0627\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u0642\u0644\u064a\u062f\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u062a\u0647\u062f\u0641 \u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0646\u0641\u0633 \u0627\u0644\u062d\u0627\u0644\u0629\u060c \u064a\u064f\u0639\u062f\u0651 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0634\u0643\u0644\u0627\u064b \u0645\u0646 \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0637\u0628 \u0627\u0644\u062f\u0642\u064a\u0642 \u0627\u0644\u0630\u064a \u064a\u064f\u0641\u064a\u062f \u0641\u0642\u0637 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0644\u062f\u064a\u0647\u0645 \u0623\u0646\u0645\u0627\u0637 \u0637\u0641\u0631\u0627\u062a \u0645\u064f\u062d\u062f\u062f\u0629. \u0625\u0646 \u0641\u0647\u0645 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u064a\u064f\u0633\u0627\u0639\u062f \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0639\u0644\u0649 \u062a\u0641\u0633\u064a\u0631 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u0634\u0643\u0644 \u0623\u0641\u0636\u0644\u060c \u0648\u0645\u062a\u0627\u0628\u0639\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0646\u0627\u0634\u0626\u0629\u060c \u0648\u0645\u0646\u0627\u0642\u0634\u0629 \u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0645\u0639 \u0623\u062e\u0635\u0627\u0626\u064a\u064a \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u0639\u0636\u0644\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u062d\u062a\u0648\u064a \u062c\u064a\u0646 DMD \u0639\u0644\u0649 79 \u0625\u0643\u0633\u0648\u0646\u064b\u0627\u060c \u0648\u0647\u0648 \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0648\u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0646\u064a\u0648\u064a \u064a\u062d\u0645\u064a \u0623\u0644\u064a\u0627\u0641 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0645\u0646 \u0627\u0644\u062a\u0644\u0641. \u0639\u0646\u062f\u0645\u0627 \u062a\u0624\u062f\u064a \u0627\u0644\u062d\u0630\u0648\u0641\u0627\u062a \u0623\u0648 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0623\u062e\u0631\u0649 \u0625\u0644\u0649 \u062a\u0639\u0637\u064a\u0644 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629\u060c \u064a\u0646\u062e\u0641\u0636 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0628\u0634\u0643\u0644 \u062d\u0627\u062f \u0623\u0648 \u064a\u0646\u0639\u062f\u0645\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0636\u0639\u0641 \u0639\u0636\u0644\u064a \u062a\u062f\u0631\u064a\u062c\u064a. \u062a\u0633\u062a\u062e\u062f\u0645 \u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0645\u0636\u0627\u062f\u0629 (ASOs) \u0644\u062a\u0634\u062c\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0639\u0644\u0649 \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0623\u062b\u0646\u0627\u0621 \u0639\u0645\u0644\u064a\u0629 \u0631\u0628\u0637 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a (RNA)\u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0639\u064a\u062f \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0623\u0642\u0635\u0631 \u0648\u0644\u0643\u0646\u0647 \u0641\u0639\u0627\u0644\u060c \u0645\u0634\u0627\u0628\u0647\u064b\u0627 \u0644\u0645\u0627 \u064a\u064f\u0644\u0627\u062d\u0638 \u0641\u064a \u0636\u0645\u0648\u0631 \u0628\u064a\u0643\u0631 \u0627\u0644\u0639\u0636\u0644\u064a. \u0644\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a: <a href=\"https:\/\/dmdwarrior.com\/ar\/dystrophin-gene\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646<\/a><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#mutations-amenable-to-exon-50-skipping\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50<\/a><\/li><li><a href=\"#how-does-exon-50-skipping-work\">\u0643\u064a\u0641 \u062a\u062a\u0645 \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u061f<\/a><\/li><li><a href=\"#why-are-only-certain-patients-eligible\">\u0644\u0645\u0627\u0630\u0627 \u064a\u0643\u0648\u0646 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u0642\u0637 \u0645\u0624\u0647\u0644\u064a\u0646\u061f<\/a><ul><li><a href=\"#who-can-benefit-from-exon-50-skipping\">\u0645\u0646 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u061f<\/a><\/li><\/ul><\/li><li><a href=\"#current-research-on-exon-50-skipping-therapy\">\u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u062d\u0648\u0644 \u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50<\/a><ul><li><a href=\"#improved-antisense-oligonucleotides\">\u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u062c\u064a\u0646\u0627\u062a \u0645\u062d\u0633\u0646\u0629<\/a><\/li><li><a href=\"#enhanced-delivery-systems\">\u0623\u0646\u0638\u0645\u0629 \u062a\u0648\u0635\u064a\u0644 \u0645\u062d\u0633\u0651\u0646\u0629<\/a><\/li><li><a href=\"#better-dystrophin-expression\">\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646<\/a><\/li><li><a href=\"#combination-therapies\">\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0628\u0629<\/a><\/li><\/ul><\/li><li><a href=\"#frequently-asked-questions\">\u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629<\/a><ul><li><a href=\"#faq-question-1785266038331\">\u0647\u0644 \u064a\u062a\u062e\u0637\u0649 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0639\u0644\u0627\u062c\u064b\u0627\u061f<\/a><\/li><li><a href=\"#faq-question-1785266050896\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u0644\u0643\u0644 \u0645\u0631\u064a\u0636 \u062a\u0644\u0642\u064a \u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u061f<\/a><\/li><li><a href=\"#faq-question-1785266059963\">\u0643\u064a\u0641 \u064a\u0645\u0643\u0646 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0645\u0624\u0647\u0644\u0629\u061f<\/a><\/li><li><a href=\"#faq-question-1785266067988\">\u0647\u0644 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0645\u062a\u0627\u062d\u0629\u061f<\/a><\/li><\/ul><\/li><li><a href=\"#future-outlook\">\u0627\u0644\u062a\u0648\u0642\u0639\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"mutations-amenable-to-exon-50-skipping\" class=\"wp-block-heading\">\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0634\u064a\u0631 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0625\u0644\u0649 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u064a\u0624\u062f\u064a \u0641\u064a\u0647\u0627 \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0625\u0644\u0649 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u0639\u0637\u0644 \u0648\u062a\u0645\u0643\u064a\u0646 \u0625\u0646\u062a\u0627\u062c \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u0638\u064a\u0641\u064a \u062c\u0632\u0626\u064a\u064b\u0627. <strong>\u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u062a\u062d\u0644\u064a\u0644\u0627\u062a \u0642\u0627\u0628\u0644\u064a\u0629 \u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629\u060c \u062a\u0645 \u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0644\u0623\u0646\u0645\u0627\u0637 \u062d\u0630\u0641 \u0645\u062d\u062f\u062f\u0629 \u062a\u0634\u0645\u0644 8-49\u060c 20-49\u060c 22-49\u060c 51\u060c 51-53\u060c 51-55\u060c 51-57\u060c 51-59\u060c 51-60\u060c 51-67\u060c 51-69\u060c 51-75\u060c \u0623\u0648 51-78.<\/strong> \u062a\u064f\u0639\u062f\u0651 \u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062d\u0630\u0641 \u0647\u0630\u0647 \u0623\u0645\u062b\u0644\u0629\u064b \u0639\u0644\u0649 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u0642\u062f \u064a\u064f\u0639\u064a\u062f \u0641\u064a\u0647\u0627 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0646\u0638\u0631\u064a\u064b\u0627. \u0645\u0639 \u0630\u0644\u0643\u060c \u064a\u0646\u0628\u063a\u064a \u062f\u0627\u0626\u0645\u064b\u0627 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0623\u0647\u0644\u064a\u0629 \u0643\u0644 \u0645\u0631\u064a\u0636 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0625\u062c\u0631\u0627\u0621 \u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0634\u0627\u0645\u0644\u0629\u060c \u0648\u062a\u062d\u0644\u064a\u0644 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629\u060c \u0648\u0627\u0633\u062a\u0634\u0627\u0631\u0629 \u0623\u062e\u0635\u0627\u0626\u064a \u0639\u0635\u0628\u064a \u0639\u0636\u0644\u064a \u0630\u064a \u062e\u0628\u0631\u0629\u060c \u0625\u0630 \u0644\u0627 \u064a\u064f\u0645\u0643\u0646 \u0627\u062a\u062e\u0627\u0630 \u0642\u0631\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0639\u062f\u062f \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0641\u0642\u0637. \u0644\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a: <a href=\"https:\/\/dmdwarrior.com\/ar\/what-is-exon-deletion-in-duchenne-muscular-dystrophy-dmd\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0627 \u0647\u0648 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u061f<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"864\" height=\"1821\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic.png\" alt=\"\u0631\u0633\u0645 \u0628\u064a\u0627\u0646\u064a \u064a\u0648\u0636\u062d \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\" class=\"wp-image-8303\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic.png 864w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-142x300.png 142w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-486x1024.png 486w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-768x1619.png 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-729x1536.png 729w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-6x12.png 6w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-199x420.png 199w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-150x316.png 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-300x632.png 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/07\/mutations-amenable-to-exon-50-skipping-infographic-696x1467.png 696w\" sizes=\"(max-width: 864px) 100vw, 864px\" \/><figcaption class=\"wp-element-caption\">\u064a\u0644\u062e\u0635 \u0647\u0630\u0627 \u0627\u0644\u0631\u0633\u0645 \u0627\u0644\u0628\u064a\u0627\u0646\u064a \u0623\u0646\u0645\u0627\u0637 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0645\u0639\u062a\u0631\u0641 \u0628\u0647\u0627 \u062d\u0627\u0644\u064a\u064b\u0627 \u0639\u0644\u0649 \u0623\u0646\u0647\u0627 \u0637\u0641\u0631\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a.<\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"how-does-exon-50-skipping-work\" class=\"wp-block-heading\">\u0643\u064a\u0641 \u062a\u062a\u0645 \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0633\u062a\u0647\u062f\u0641 \u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 (mRNA) \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a (DNA). \u0628\u0639\u062f \u0646\u0633\u062e \u062c\u064a\u0646 DMD \u0625\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a\u060c \u062a\u0631\u062a\u0628\u0637 \u0642\u0644\u064a\u0644 \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u062a\u062c\u0627\u0647 \u0628\u062a\u0633\u0644\u0633\u0644\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u062d\u0648\u0644 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0627\u0633\u062a\u0628\u0639\u0627\u062f \u0622\u0644\u064a\u0629 \u0627\u0644\u062a\u0636\u0641\u064a\u0631 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 \u0644\u0647\u0630\u0627 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0623\u062b\u0646\u0627\u0621 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0627\u0644\u0647\u062f\u0641 \u0627\u0644\u0639\u0644\u0627\u062c\u064a \u0647\u0648:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u0645\u0639\u0637\u0644<\/li>\n\n\n\n<li>\u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0642\u0635\u064a\u0631 \u062f\u0627\u062e\u0644\u064a\u064b\u0627<\/li>\n\n\n\n<li>\u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0628\u0637\u064a\u0621<\/li>\n\n\n\n<li>\u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0642\u0648\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0648\u0648\u0638\u064a\u0641\u062a\u0647\u0627<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u0639\u0644\u0649 \u0639\u0643\u0633 \u062a\u0642\u0646\u064a\u0627\u062a \u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0645\u062b\u0644 CRISPR\u060c \u0641\u0625\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0644\u0627 \u064a\u064f\u063a\u064a\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0628\u0634\u0643\u0644 \u062f\u0627\u0626\u0645. \u0628\u0644 \u064a\u064f\u063a\u064a\u0631 \u0645\u0624\u0642\u062a\u064b\u0627 \u0643\u064a\u0641\u064a\u0629 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a (RNA)\u060c \u0645\u0645\u0627 \u064a\u0639\u0646\u064a \u0623\u0646 \u0627\u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u0645\u062a\u0643\u0631\u0631\u0629 \u0645\u0637\u0644\u0648\u0628\u0629 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"why-are-only-certain-patients-eligible\" class=\"wp-block-heading\">\u0644\u0645\u0627\u0630\u0627 \u064a\u0643\u0648\u0646 \u0628\u0639\u0636 \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u0642\u0637 \u0645\u0624\u0647\u0644\u064a\u0646\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0634\u064a\u0648\u0639\u0627\u064b \u0627\u0644\u062a\u064a \u062a\u0637\u0631\u062d\u0647\u0627 \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0647\u0648:<\/p>\n\n\n\n<h3 id=\"who-can-benefit-from-exon-50-skipping\" class=\"wp-block-heading\">\u0645\u0646 \u064a\u0645\u0643\u0646\u0647 \u0627\u0644\u0627\u0633\u062a\u0641\u0627\u062f\u0629 \u0645\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u061f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0644\u0627 \u064a\u064f\u0639\u062a\u0628\u0631 \u0627\u0644\u0645\u0631\u0634\u062d\u0648\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644\u0648\u0646 \u0625\u0644\u0627 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0648\u0627\u0641\u0642 \u0637\u0641\u0631\u0627\u062a\u0647\u0645 \u0645\u0639 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50.<\/strong> \u0644\u0623\u0646 \u0643\u0644 \u0637\u0641\u0631\u0629 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a DMD \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0628\u0634\u0643\u0644 \u0645\u062e\u062a\u0644\u0641\u060c \u0641\u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0646\u0641\u0633 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0643\u0644 \u0645\u0631\u064a\u0636.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0639\u062a\u0645\u062f \u0627\u0644\u0623\u0647\u0644\u064a\u0629 \u0639\u0644\u0649 \u0639\u062f\u0629 \u0639\u0648\u0627\u0645\u0644:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u0646\u0645\u0637 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u062f\u0642\u064a\u0642<\/li>\n\n\n\n<li>\u0627\u0636\u0637\u0631\u0627\u0628 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629<\/li>\n\n\n\n<li>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u062c\u0632\u064a\u0626\u064a<\/li>\n\n\n\n<li>\u0645\u0639\u0627\u064a\u064a\u0631 \u0625\u062f\u0631\u0627\u062c \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629<\/li>\n\n\n\n<li>\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u062a\u0646\u0638\u064a\u0645\u064a\u0629<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0645\u0643\u0646 \u0644\u0645\u062e\u062a\u0628\u0631 \u0648\u0631\u0627\u062b\u064a \u0645\u0639\u062a\u0645\u062f \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0637\u0641\u0631\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0642\u0627\u0628\u0644\u0629 \u0646\u0638\u0631\u064a\u0627\u064b \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"current-research-on-exon-50-skipping-therapy\" class=\"wp-block-heading\">\u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0627\u0644\u062d\u0627\u0644\u064a\u0629 \u062d\u0648\u0644 \u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0639\u062a\u0645\u062f\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u062a\u0633\u062a\u0647\u062f\u0641 \u062d\u0627\u0644\u064a\u064b\u0627 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0645\u062b\u0644 45 \u064851 \u064853 \u0641\u064a \u0628\u0639\u0636 \u0627\u0644\u0645\u0646\u0627\u0637\u0642\u060c \u0625\u0644\u0627 \u0623\u0646 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u064a\u0648\u0627\u0635\u0644\u0648\u0646 \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0639\u0644\u0627\u062c\u0627\u062a \u0644\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 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\u0627\u0644\u0642\u0644\u0628.<\/p>\n\n\n\n<h3 id=\"better-dystrophin-expression\" class=\"wp-block-heading\">\u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u062a\u0639\u0628\u064a\u0631 \u0639\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0642\u0648\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0628\u062a\u0642\u064a\u064a\u0645 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u062a\u0631\u0643\u064a\u0628\u0627\u062a \u0627\u0644\u0643\u064a\u0645\u064a\u0627\u0626\u064a\u0629 \u0627\u0644\u0623\u062d\u062f\u062b \u0642\u0627\u062f\u0631\u0629 \u0639\u0644\u0649 \u0632\u064a\u0627\u062f\u0629 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0645\u0639 \u0627\u0644\u062d\u0641\u0627\u0638 \u0639\u0644\u0649 \u0627\u0644\u0633\u0644\u0627\u0645\u0629.<\/p>\n\n\n\n<h3 id=\"combination-therapies\" class=\"wp-block-heading\">\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u0631\u0643\u0628\u0629<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u0642\u062f \u062a\u062c\u0645\u0639 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629 \u0628\u064a\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a\u060c \u0623\u0648 \u062a\u062d\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a\u060c \u0623\u0648 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a\u060c \u0623\u0648 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0648\u0627\u0642\u064a\u0629 \u0644\u0644\u0639\u0636\u0644\u0627\u062a.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">\u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list\">\n<div id=\"faq-question-1785266038331\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0647\u0644 \u064a\u062a\u062e\u0637\u0649 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0639\u0644\u0627\u062c\u064b\u0627\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u0644\u0627. \u064a\u0639\u062a\u0628\u0631 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0639\u0644\u0627\u062c\u064b\u0627 \u0645\u0639\u062f\u0644\u064b\u0627 \u0644\u0644\u0645\u0631\u0636 \u064a\u0647\u062f\u0641 \u0625\u0644\u0649 \u062a\u062d\u0633\u064a\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0628\u062f\u0644\u0627\u064b 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\u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u0641\u0635\u0644. <strong>\u0627\u0633\u062a\u0643\u0634\u0641 \u0627\u0644\u0622\u0646<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/ar\/duchenne-exon-deletion-tool\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0623\u062f\u0627\u0629 \u0641\u062d\u0635 \u0625\u0643\u0633\u0648\u0646 DMDWarrioR<\/a><\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1785266059963\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0643\u064a\u0641 \u064a\u0645\u0643\u0646 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0645\u0624\u0647\u0644\u0629\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u064a\u0646\u0628\u063a\u064a \u062a\u062d\u062f\u064a\u062f \u0627\u0644\u0623\u0647\u0644\u064a\u0629 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 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\u064a\u0646\u0628\u063a\u064a \u0639\u0644\u0649 \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0645\u0631\u0627\u062c\u0639\u0629 \u0645\u0648\u0642\u0639 ClinicalTrials.gov \u0628\u0627\u0646\u062a\u0638\u0627\u0645 \u0648\u0645\u0646\u0627\u0642\u0634\u0629 \u0641\u0631\u0635 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0645\u0639 \u0641\u0631\u064a\u0642 \u0627\u0644\u0631\u0639\u0627\u064a\u0629 \u0627\u0644\u0635\u062d\u064a\u0629 \u0627\u0644\u062e\u0627\u0635 \u0628\u0647\u0645. <strong>\u0627\u0633\u062a\u0643\u0634\u0641 \u0627\u0644\u0622\u0646<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/ar\/clinical-trials\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0631\u0643\u0632 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 DMDWarrioR<\/a><\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 id=\"future-outlook\" class=\"wp-block-heading\">\u0627\u0644\u062a\u0648\u0642\u0639\u0627\u062a \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u062a\u0637\u0648\u0631 \u0645\u0633\u062a\u0642\u0628\u0644 \u0627\u0644\u0637\u0628 \u0627\u0644\u062f\u0642\u064a\u0642 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0628\u0648\u062a\u064a\u0631\u0629 \u0645\u062a\u0633\u0627\u0631\u0639\u0629. \u0641\u0627\u0644\u062a\u0637\u0648\u0631\u0627\u062a \u0641\u064a \u062a\u0642\u0646\u064a\u0627\u062a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a\u060c \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0628\u062f\u064a\u0644\u060c \u0648\u062a\u0639\u062f\u064a\u0644 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0637\u0641\u0631\u0629 CRISPR\u060c \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0639\u0644\u0649 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a\u060c \u0648\u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u062a\u0648\u0635\u064a\u0644 \u0627\u0644\u062d\u062f\u064a\u062b\u0629\u060c \u062a\u064f\u0648\u0633\u0639 \u0646\u0637\u0627\u0642 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u064f\u062e\u0635\u0635\u0629 \u0644\u0643\u0644 \u0637\u0641\u0631\u0629. \u0648\u0645\u0639 \u0627\u0632\u062f\u064a\u0627\u062f \u0641\u0647\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0644\u062c\u064a\u0646 DMD \u0648\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0627 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0642\u062f \u064a\u0635\u0628\u062d \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0645\u0624\u0647\u0644\u064a\u0646 \u0644\u062a\u0644\u0642\u064a \u0639\u0644\u0627\u062c\u0627\u062a \u0645\u064f\u062e\u0635\u0635\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a\u060c \u064a\u0638\u0644 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0627\u0637\u0644\u0627\u0639 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0646\u0638\u0645\u0627\u062a \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u0630\u0627\u062a \u0627\u0644\u0633\u0645\u0639\u0629 \u0627\u0644\u0637\u064a\u0628\u0629\u060c \u0648\u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0645\u062a \u0645\u0631\u0627\u062c\u0639\u062a\u0647\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0646\u0638\u0631\u0627\u0621\u060c \u0648\u0627\u0644\u0645\u062a\u062e\u0635\u0635\u064a\u0646 \u0630\u0648\u064a \u0627\u0644\u062e\u0628\u0631\u0629 \u0641\u064a \u0645\u062c\u0627\u0644 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0639\u0635\u0628\u064a\u0629 \u0627\u0644\u0639\u0636\u0644\u064a\u0629\u060c \u0647\u0648 \u0623\u0641\u0636\u0644 \u0637\u0631\u064a\u0642\u0629 \u0644\u0644\u0627\u0633\u062a\u0639\u062f\u0627\u062f \u0644\u0644\u0641\u0631\u0635 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u062a\u0639\u0644\u0645 \u0623\u0643\u062b\u0631: <a href=\"https:\/\/clinicaltrials.gov\/\" target=\"_blank\" rel=\"noreferrer noopener\">ClinicalTrials.gov<\/a>. \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062c\u0627\u0631\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Mutations amenable to exon 50 skipping are an important topic in Duchenne muscular dystrophy (DMD) research because exon skipping therapies are designed to restore the disrupted reading frame of the DMD gene in patients with specific genetic mutations. Unlike conventional treatments that target all individuals with the same condition, exon skipping is a form of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8302,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[278,279,475,280,77,178],"class_list":["post-4085","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dmd","tag-exon-50","tag-exon-50-skipping","tag-exon-50-skipping-therapy","tag-exon-50-skipping-treatment","tag-exon-skipping","tag-exon-skipping-therapies"],"subtitle":"\u0642\u062f \u062a\u0641\u062a\u062d \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0633\u0645\u062d \u0628\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50 \u0622\u0641\u0627\u0642\u064b\u0627 \u062c\u062f\u064a\u062f\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u062e\u0635\u064a \u0644\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a. \u062a\u0639\u0631\u0651\u0641 \u0639\u0644\u0649 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0624\u0647\u0644\u0643 \u0644\u0647\u0630\u0627 \u0627\u0644\u0639\u0644\u0627\u062c\u060c \u0648\u0643\u064a\u0641\u064a\u0629 \u0639\u0645\u0644 \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 50\u060c \u0648\u0644\u0645\u0627\u0630\u0627 \u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u062f\u0642\u064a\u0642 \u0636\u0631\u0648\u0631\u064a\u064b\u0627 \u0644\u062a\u062d\u062f\u064a\u062f \u0623\u0647\u0644\u064a\u0629 \u0627\u0644\u0645\u0631\u064a\u0636 \u0648\u0641\u0631\u0635 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u0629 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0642\u0628\u0644\u064a\u0629.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4085","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=4085"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/4085\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/8302"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=4085"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=4085"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=4085"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}