{"id":3338,"date":"2026-08-10T17:10:33","date_gmt":"2026-08-10T14:10:33","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=3338"},"modified":"2026-08-10T17:36:32","modified_gmt":"2026-08-10T14:36:32","slug":"mutations-amenable-to-exon-45-skipping","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/mutations-amenable-to-exon-45-skipping\/","title":{"rendered":"\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a: \u0627\u0644\u062d\u0630\u0641 \u0648\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0643\u0648\u0646 \u0645\u0624\u0647\u0644\u0629"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0641\u064a \u0627\u0644\u0633\u0646\u0648\u0627\u062a \u0627\u0644\u0623\u062e\u064a\u0631\u0629\u060c \u0628\u0631\u0632 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0643\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0648\u0627\u0639\u062f\u0629 \u0644\u0623\u0646\u0648\u0627\u0639 \u0645\u0639\u064a\u0646\u0629 \u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0641\u064a \u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646. \u0648\u064a\u064f\u0639\u062f \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u0646 \u0623\u0643\u062b\u0631 \u0627\u0644\u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0627\u062a \u0627\u0644\u062a\u064a \u062e\u0636\u0639\u062a \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0644\u0645\u0639\u0627\u0644\u062c\u0629 \u0637\u0641\u0631\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a. <strong>\u0625\u0630\u0646\u060c \u0647\u0644 \u062a\u062a\u0633\u0627\u0621\u0644 \u0639\u0646 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u062d\u062f\u062b \u0646\u062a\u064a\u062c\u0629 \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/strong> \u064a\u0647\u062f\u0641 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0625\u0644\u0649 \u062a\u062e\u0637\u064a \u0625\u0643\u0633\u0648\u0646 \u0645\u0639\u064a\u0628 \u0623\u062b\u0646\u0627\u0621 \u0639\u0645\u0644\u064a\u0629 \u062a\u0636\u0641\u064a\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a (RNA) \u0644\u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0644\u062c\u064a\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0645\u0628\u062a\u0648\u0631 \u0648\u0644\u0643\u0646\u0647 \u0648\u0638\u064a\u0641\u064a. \u0648\u064a\u0645\u0643\u0646 \u0644\u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0648\u0638\u064a\u0641\u0629 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0623\u0646 \u062a\u0628\u0637\u0626 \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0648\u062a\u062d\u0633\u0646 \u0648\u0638\u064a\u0641\u0629 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a \u0645\u062d\u062f\u062f\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0625\u0646 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062c\u0627\u0648\u0632 \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0647\u064a \u062a\u063a\u064a\u064a\u0631\u0627\u062a \u0645\u062d\u062f\u062f\u0629 \u0641\u064a \u062c\u064a\u0646 DMD \u0648\u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0639\u0644\u0627\u062c\u0647\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646.<\/strong> \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0627\u0644\u0645\u062a\u0636\u0631\u0631\u0629 \u0645\u0646 \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (DMD)\u060c \u064a\u064f\u0639\u062f\u0651 \u0641\u0647\u0645 \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0644\u062f\u0649 \u0627\u0644\u0637\u0641\u0644 \u0642\u0627\u0628\u0644\u0629\u064b \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0623\u0645\u0631\u064b\u0627 \u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0639\u0646\u062f \u0627\u0644\u0646\u0638\u0631 \u0641\u064a \u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0630\u0647 \u0627\u0644\u0637\u0641\u0631\u0629. \u0645\u0639 \u0630\u0644\u0643\u060c \u0641\u0625\u0646 \u0648\u062c\u0648\u062f \u062d\u0630\u0641 \u0645\u0639\u064a\u0646 \u0641\u064a \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0644\u0627 \u064a\u064f\u062b\u0628\u062a \u0648\u062d\u062f\u0647 \u0623\u0647\u0644\u064a\u0629 \u0627\u0644\u0637\u0641\u0644 \u0644\u0644\u0639\u0644\u0627\u062c. \u064a\u0646\u0628\u063a\u064a \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0645\u0646 \u0642\u0650\u0628\u0644 \u0623\u062e\u0635\u0627\u0626\u064a \u0623\u0645\u0631\u0627\u0636 \u0639\u0635\u0628\u064a\u0629 \u0639\u0636\u0644\u064a\u0629 \u0623\u0648 \u0645\u0633\u062a\u0634\u0627\u0631 \u0648\u0631\u0627\u062b\u064a. \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f: <a href=\"https:\/\/dmdwarrior.com\/ar\/what-is-exon-skipping-and-how-does-it-work\/\" data-type=\"post\" data-id=\"1445\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0627 \u0647\u0648 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646<\/a><\/p>\n\n\n\n<div class=\"wp-block-rank-math-toc-block\" id=\"rank-math-toc\"><h2>\u062c\u062f\u0648\u0644 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0627\u062a<\/h2><nav><ul><li><a href=\"#what-is-exon-45-skipping-in-duchenne-muscular-dystrophy\">\u0645\u0627 \u0647\u0648 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u061f<\/a><\/li><li><a href=\"#which-dmd-deletions-are-amenable-to-exon-45-skipping\">\u0645\u0627 \u0647\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u062d\u0630\u0641 DMD \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627\u061f<\/a><\/li><li><a href=\"#why-does-the-reading-frame-matter\">\u0644\u0645\u0627\u0630\u0627 \u064a\u064f\u0639\u062f\u0651 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0645\u0647\u0645\u064b\u0627\u061f<\/a><\/li><li><a href=\"#which-dmd-mutations-can-be-treated-by-exon-45-skipping\">\u0645\u0627 \u0647\u064a \u0637\u0641\u0631\u0627\u062a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0639\u0644\u0627\u062c\u0647\u0627 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/a><\/li><li><a href=\"#is-my-dmd-mutation-amenable-to-exon-45-skipping\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a \u0637\u0641\u0631\u0629 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0644\u062f\u064a\u061f<\/a><\/li><li><a href=\"#exon-45-skipping-treatment-casimersen\">\u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45: \u0643\u0627\u0633\u064a\u0645\u064a\u0631\u0633\u064a\u0646<\/a><\/li><li><a href=\"#exon-45-skipping-is-not-the-same-for-every-patient\">\u0644\u0627 \u064a\u0643\u0648\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u062a\u0645\u0627\u062b\u0644\u0627\u064b \u0644\u062f\u0649 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649<\/a><\/li><li><a href=\"#how-to-check-whether-a-dmd-deletion-is-exon-45-skip-amenable\">\u0643\u064a\u0641\u064a\u0629 \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u062d\u0630\u0641 \u062c\u064a\u0646 DMD \u0642\u0627\u0628\u0644\u0627\u064b \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45<\/a><\/li><li><a href=\"#why-accurate-genetic-testing-matters\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0645\u0647\u0645\u0629\u061f<\/a><\/li><li><a href=\"#frequently-asked-questions-about-exon-45-skipping\">\u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u062d\u0648\u0644 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45<\/a><ul><li><a href=\"#faq-question-1786370195246\">\u0645\u0627 \u0647\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627\u061f<\/a><\/li><li><a href=\"#faq-question-1786370214456\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 46 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/a><\/li><li><a href=\"#faq-question-1786370222218\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 46-49 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/a><\/li><li><a href=\"#faq-question-1786370242273\">\u0645\u0627 \u0647\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u062a\u0627\u062d \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/a><\/li><li><a href=\"#faq-question-1786370250501\">\u0647\u0644 \u062a\u0636\u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0646\u062c\u0627\u062d \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u061f<\/a><\/li><\/ul><\/li><li><a href=\"#conclusion\">\u062e\u0627\u062a\u0645\u0629<\/a><\/li><\/ul><\/nav><\/div>\n\n\n\n<h2 id=\"what-is-exon-45-skipping-in-duchenne-muscular-dystrophy\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u0648 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0646\u062a\u062c \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0639\u0646 \u0637\u0641\u0631\u0627\u062a \u062c\u064a\u0646\u064a\u0629 \u0645\u0645\u0631\u0636\u0629 \u0641\u064a \u062c\u064a\u0646 DMD\u060c \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0648\u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u064a\u062d\u0645\u064a \u0623\u0644\u064a\u0627\u0641 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u0627\u0646\u0642\u0628\u0627\u0636. \u0648\u062a\u064f\u0639\u062f\u0651 \u0627\u0644\u062d\u0630\u0648\u0641\u0627\u062a \u0627\u0644\u0643\u0628\u064a\u0631\u0629 \u0645\u0646 \u0623\u0643\u062b\u0631 \u0623\u0646\u0648\u0627\u0639 \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0633\u0628\u0628\u0629 \u0644\u0644\u0645\u0631\u0636 \u0634\u064a\u0648\u0639\u064b\u0627 \u0641\u064a \u062c\u064a\u0646 DMD. \u062a\u0639\u0631\u0651\u0641 \u0627\u0644\u0622\u0646:\u00a0<a href=\"https:\/\/dmdwarrior.com\/ar\/dystrophin-gene\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0645\u0627 \u0647\u0648 \u062c\u064a\u0646 DMD\u061f<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0624\u062f\u064a \u0628\u0639\u0636 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0625\u0644\u0649 \u062a\u0639\u0637\u064a\u0644 \u0625\u0637\u0627\u0631 \u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u062c\u064a\u0646. \u0648\u0639\u0646\u062f \u062d\u062f\u0648\u062b \u0630\u0644\u0643\u060c \u0642\u062f \u0644\u0627 \u064a\u0648\u0641\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 \u0627\u0644\u0646\u0627\u062a\u062c \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0627\u0644\u0635\u062d\u064a\u062d\u0629 \u0644\u0625\u0646\u062a\u0627\u062c \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0648\u0638\u064a\u0641\u064a. \u0635\u064f\u0645\u0645\u062a \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0644\u0625\u0632\u0627\u0644\u0629 \u0625\u0643\u0633\u0648\u0646 \u0645\u062d\u062f\u062f \u0623\u062b\u0646\u0627\u0621 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a\u060c \u0628\u062d\u064a\u062b \u064a\u0645\u0643\u0646 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u0645\u062a\u0628\u0642\u064a \u0625\u0644\u0649 \u062a\u0643\u0648\u064a\u0646\u0647 \u0627\u0644\u0635\u062d\u064a\u062d.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0641\u064a \u0639\u0645\u0644\u064a\u0629 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u060c \u064a\u064f\u0635\u0645\u064e\u0651\u0645 \u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0645\u0636\u0627\u062f \u0644\u0644\u062c\u064a\u0646 \u0644\u064a\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u0646 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 \u0627\u0644\u0623\u0648\u0644\u064a \u0644\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u064f\u0639\u0632\u0632 \u0627\u0633\u062a\u0628\u0639\u0627\u062f\u0647 \u0623\u062b\u0646\u0627\u0621 \u0645\u0639\u0627\u0644\u062c\u0629 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a. \u0648\u0627\u0644\u0647\u062f\u0641 \u0645\u0646 \u0630\u0644\u0643 \u0647\u0648 \u0625\u0646\u062a\u0627\u062c \u0628\u0631\u0648\u062a\u064a\u0646 \u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0623\u0642\u0635\u0631 \u0642\u062f \u064a\u062d\u062a\u0641\u0638 \u0628\u062e\u0635\u0627\u0626\u0635 \u0648\u0638\u064a\u0641\u064a\u0629 \u0645\u0647\u0645\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u062e\u0627\u0635 \u0628\u0627\u0644\u0637\u0641\u0631\u0629. \u064a\u062c\u0628 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u0648\u062c\u0648\u062f\u064b\u0627 \u0641\u064a \u062c\u064a\u0646 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u064a\u0636 \u062d\u062a\u0649 \u062a\u0646\u062c\u062d \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45.<\/p>\n\n\n\n<h2 id=\"which-dmd-deletions-are-amenable-to-exon-45-skipping\" class=\"wp-block-heading\">\u0645\u0627 \u0647\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u062d\u0630\u0641 DMD \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u062a\u0634\u0645\u0644 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627\u060c \u0648\u0627\u0644\u062a\u064a \u062a\u0645 \u0648\u0635\u0641\u0647\u0627 \u0628\u0623\u0646\u0647\u0627 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0646\u0638\u0631\u064a\u064b\u0627 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062c\u0639 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629\u060c \u0645\u0627 \u064a\u0644\u064a:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>7-44\u060c 12-44\u060c 18-44\u060c 44\u060c 46\u060c 46-47\u060c 46-48\u060c 46-49\u060c 46-51\u060c 46-53\u060c 46-55\u060c 46-57\u060c 46-59\u060c 46-60\u060c 46-67\u060c 46-69\u060c 46-75\u060c \u064846-78.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"968\" height=\"1024\" src=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-968x1024.jpg\" alt=\"\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\" class=\"wp-image-3341\" title=\"\" srcset=\"https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-968x1024.jpg 968w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-284x300.jpg 284w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-768x813.jpg 768w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-1452x1536.jpg 1452w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-11x12.jpg 11w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-397x420.jpg 397w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-150x159.jpg 150w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-300x317.jpg 300w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-696x737.jpg 696w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping-1068x1130.jpg 1068w, https:\/\/dmdwarrior.com\/wp-content\/uploads\/2025\/03\/Mutations-are-Amenable-to-Exon-45-Skipping.jpg 1890w\" sizes=\"(max-width: 968px) 100vw, 968px\" \/><figcaption class=\"wp-element-caption\"><strong>\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45<\/strong><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u062a\u0646\u0639\u0643\u0633 \u0647\u0630\u0647 \u0627\u0644\u0642\u0627\u0626\u0645\u0629 \u0623\u064a\u0636\u064b\u0627 \u0641\u064a \u0627\u0644\u0645\u0648\u0627\u0631\u062f \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u062f\u0648\u0627\u0621 \u0643\u0627\u0633\u064a\u0645\u064a\u0631\u0633\u064a\u0646 \u0648\u0641\u064a \u0627\u0644\u0623\u0648\u0635\u0627\u0641 \u0627\u0644\u0645\u0646\u0634\u0648\u0631\u0629 \u0644\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0628\u0631 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u062c\u0627\u0648\u0632 \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0635\u0641 \u0647\u0630\u0627 \u0627\u0644\u062a\u0631\u0645\u064a\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0627\u0644\u0645\u062d\u0630\u0648\u0641\u0629. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644\u060c \u064a\u0634\u064a\u0631 \u0627\u0644\u0631\u0645\u0632 46-49 \u0625\u0644\u0649 \u063a\u064a\u0627\u0628 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 46 \u064847 \u064848 \u064849. \u0641\u064a \u0627\u0644\u0645\u0642\u0627\u0628\u0644\u060c \u064a\u0634\u064a\u0631 \u0627\u0644\u0631\u0645\u0632 44 \u0648\u062d\u062f\u0647 \u0625\u0644\u0649 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 44.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0645\u0646 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class=\"wp-block-heading\">\u0639\u0644\u0627\u062c \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45: \u0643\u0627\u0633\u064a\u0645\u064a\u0631\u0633\u064a\u0646<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u064f\u0639\u062f\u0651 \u062f\u0648\u0627\u0621 \u0643\u0627\u0633\u064a\u0645\u064a\u0631\u0633\u064a\u0646\u060c \u0627\u0644\u0630\u064a \u064a\u064f\u0633\u0648\u0651\u0642 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u062a\u062d\u062a \u0627\u0633\u0645 \u0623\u0645\u0648\u0646\u062f\u064a\u0633 45\u060c \u0623\u062d\u062f \u0623\u0634\u0647\u0631 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u0639\u062a\u0645\u062f \u0639\u0644\u0649 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45. \u0648\u0642\u062f \u0648\u0627\u0641\u0642\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 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\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0646\u0634\u0637\u0629 \u0644\u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a<\/a><\/p>\n\n\n\n<h2 id=\"exon-45-skipping-is-not-the-same-for-every-patient\" class=\"wp-block-heading\">\u0644\u0627 \u064a\u0643\u0648\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u062a\u0645\u0627\u062b\u0644\u0627\u064b \u0644\u062f\u0649 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0646 \u0645\u0635\u0637\u0644\u062d \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u0642\u0627\u0628\u0644 \u0644\u0644\u062a\u062c\u0627\u0648\u0632 \u0641\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u064a\u0635\u0641 \u0641\u0631\u0635\u0629 \u062c\u064a\u0646\u064a\u0629\u060c \u0648\u0644\u064a\u0633 \u0636\u0645\u0627\u0646\u064b\u0627 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\u0625\u0644\u0649 \u0623\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0628\u0646\u064a\u0629 \u0627\u0644\u062d\u0630\u0641 \u0648\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0627\u0644\u0646\u0627\u062a\u062c \u0642\u062f \u062a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0628\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0648\u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u062a\u062d\u0644\u064a\u0644\u064a\u0629 \u0634\u0627\u0645\u0644\u0629 \u0648\u0627\u0633\u0639\u0629 \u0627\u0644\u0646\u0637\u0627\u0642\u060c \u062a\u0646\u0627\u0648\u0644\u062a \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062d\u0630\u0641 \u0648\u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0643\u0627\u0641\u0626\u0629 \u0644\u0644\u062d\u0630\u0641\u060c \u0623\u0646 \u0645\u0646\u0647\u062c\u064a\u0629 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0645\u0641\u064a\u062f\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0644\u064a\u0633\u062a \u0645\u0624\u0634\u0631\u0627\u064b \u062f\u0642\u064a\u0642\u0627\u064b \u0644\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a \u0627\u0644\u0633\u0631\u064a\u0631\u064a. \u0643\u0645\u0627 \u0633\u0644\u0637 \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0627\u0644\u0636\u0648\u0621 \u0639\u0644\u0649 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0628\u064a\u0646 \u0623\u0646\u0645\u0627\u0637 \u0627\u0644\u062d\u0630\u0641\u060c \u0648\u0636\u0631\u0648\u0631\u0629 \u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0639\u0644\u0627\u0642\u0629 \u0628\u064a\u0646 \u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u062c\u064a\u0646\u064a \u0648\u0627\u0644\u0646\u0645\u0637 \u0627\u0644\u0638\u0627\u0647\u0631\u064a \u0628\u0639\u0646\u0627\u064a\u0629.<\/p>\n\n\n\n<h2 id=\"how-to-check-whether-a-dmd-deletion-is-exon-45-skip-amenable\" class=\"wp-block-heading\">\u0643\u064a\u0641\u064a\u0629 \u062a\u062d\u062f\u064a\u062f \u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u062d\u0630\u0641 \u062c\u064a\u0646 DMD \u0642\u0627\u0628\u0644\u0627\u064b \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0646\u0628\u063a\u064a \u0639\u0644\u0649 \u0627\u0644\u0639\u0627\u0626\u0644\u0627\u062a \u0623\u0646 \u062a\u0628\u062f\u0623 \u0628\u0627\u0644\u062a\u0634\u062e\u064a\u0635 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u0624\u0643\u062f \u0644\u0644\u0637\u0641\u0644\u060c \u0648\u0644\u064a\u0633 \u0645\u062c\u0631\u062f \u0627\u0633\u0645 \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u0645\u0634\u062a\u0628\u0647 \u0628\u0647\u0627.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0630\u0627 \u0627\u062d\u062a\u0648\u0649 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0639\u0644\u0649 \u062d\u0630\u0641\u060c \u0641\u062d\u062f\u062f \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0644\u0623\u0648\u0644 \u0648\u0627\u0644\u0623\u062e\u064a\u0631 \u0627\u0644\u0645\u062d\u0630\u0648\u0641. \u062b\u0645 \u062a\u062d\u0642\u0642 \u0645\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0627\u0644\u062d\u0630\u0641 \u0645\u0648\u062c\u0648\u062f\u064b\u0627 \u0641\u064a \u0642\u0627\u0626\u0645\u0629 \u0645\u0631\u062c\u0639\u064a\u0629 \u0645\u0639\u062a\u0645\u062f\u0629 \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45. \u0648\u0623\u062e\u064a\u0631\u064b\u0627\u060c \u0627\u0637\u0644\u0628 \u0645\u0646 \u0637\u0628\u064a\u0628 \u0623\u0639\u0635\u0627\u0628 \u0623\u0648 \u0645\u0633\u062a\u0634\u0627\u0631 \u0648\u0631\u0627\u062b\u064a \u0630\u064a \u062e\u0628\u0631\u0629 \u0641\u064a \u0645\u0631\u0636 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0646\u062a\u064a\u062c\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0637\u0641\u0631\u0627\u062a DMD \u0623\u0648 \u0623\u062f\u0627\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0645\u0641\u064a\u062f\u0629 \u0644\u0644\u0623\u063a\u0631\u0627\u0636 \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a\u0629\u060c \u0648\u0644\u0643\u0646 \u0644\u0627 \u064a\u0646\u0628\u063a\u064a \u0623\u0646 \u062a\u062d\u0644 \u0627\u0644\u0623\u062f\u0648\u0627\u062a \u0639\u0628\u0631 \u0627\u0644\u0625\u0646\u062a\u0631\u0646\u062a \u0645\u062d\u0644 \u0627\u0644\u062a\u0641\u0633\u064a\u0631 \u0627\u0644\u0645\u0647\u0646\u064a \u0644\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a.<\/p>\n\n\n\n<h2 id=\"why-accurate-genetic-testing-matters\" class=\"wp-block-heading\">\u0644\u0645\u0627\u0630\u0627 \u062a\u064f\u0639\u062f\u0651 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0645\u0647\u0645\u0629\u061f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u064a\u064f\u0639\u062f\u0651 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0623\u0633\u0627\u0633\u064a\u064b\u0627 \u0644\u062a\u062d\u062f\u064a\u062f \u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0643\u0644 \u0637\u0641\u0631\u0629 \u0641\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a. \u0641\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u062a\u064f\u0633\u0627\u0639\u062f \u0627\u0644\u0623\u0637\u0628\u0627\u0621 \u0639\u0644\u0649 \u062a\u0642\u064a\u064a\u0645 \u0645\u062f\u0649 \u0645\u0644\u0627\u0621\u0645\u0629 \u0627\u0644\u0645\u0631\u0636\u0649 \u0644\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062a\u064a \u062a\u064f\u0642\u0644\u0644 \u0645\u0646 \u0639\u062f\u062f \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a\u060c \u0643\u0645\u0627 \u0623\u0646\u0647\u0627 \u062a\u064f\u0639\u062f\u0651 \u0645\u0647\u0645\u0629 \u0623\u064a\u0636\u064b\u0627 \u0644\u0641\u062d\u0635 \u0627\u0644\u0645\u0634\u0627\u0631\u0643\u064a\u0646 \u0641\u064a \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0648\u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0627\u0633\u062a\u0634\u0627\u0631\u0627\u062a \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0644\u0639\u0627\u0626\u0644\u0627\u062a\u060c \u0641\u0625\u0646 \u0627\u0644\u0633\u0624\u0627\u0644 \u0627\u0644\u0623\u0643\u062b\u0631 \u0641\u0627\u0626\u062f\u0629 \u0644\u064a\u0633 \u0628\u0628\u0633\u0627\u0637\u0629 &quot;\u0647\u0644 \u064a\u0639\u0627\u0646\u064a \u0637\u0641\u0644\u064a \u0645\u0646 \u062d\u0630\u0641\u061f&quot; \u0628\u0644:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u201c&quot;\u0645\u0627 \u0647\u0648 \u0627\u0644\u062d\u0630\u0641 \u0628\u0627\u0644\u0636\u0628\u0637\u060c \u0648\u0647\u0644 \u064a\u0639\u0637\u0644 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629\u060c \u0648\u0647\u0644 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0625\u0644\u0649 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0647\u0630\u0627 \u0627\u0644\u0625\u0637\u0627\u0631\u061f&quot;\u201d<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0625\u0646 \u0641\u0647\u0645 \u0647\u0630\u0627 \u0627\u0644\u062a\u0645\u064a\u064a\u0632 \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u062d\u0648\u0644 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0645\u0639\u0642\u062f \u0625\u0644\u0649 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u064a\u0633\u0647\u0644 \u0645\u0646\u0627\u0642\u0634\u062a\u0647\u0627 \u0645\u0639 \u0623\u062e\u0635\u0627\u0626\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a.<\/p>\n\n\n\n<h2 id=\"frequently-asked-questions-about-exon-45-skipping\" class=\"wp-block-heading\">\u0627\u0644\u0623\u0633\u0626\u0644\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u062d\u0648\u0644 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list\">\n<div id=\"faq-question-1786370195246\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0645\u0627 \u0647\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062d\u0630\u0641 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u062a\u0634\u0645\u0644 \u0627\u0644\u062d\u0630\u0648\u0641\u0627\u062a \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0646\u0638\u0631\u064a\u0627\u064b \u0627\u0644\u0645\u0648\u0627\u0642\u0639 \u0627\u0644\u062a\u0627\u0644\u064a\u0629: 7-44\u060c 12-44\u060c 18-44\u060c 44\u060c 46\u060c 46-47\u060c 46-48\u060c 46-49\u060c 46-51\u060c 46-53\u060c 46-55\u060c 46-57\u060c 46-59\u060c 46-60\u060c 46-67\u060c 46-69\u060c 46-75\u060c \u064846-78. \u064a\u062c\u0628 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0623\u0647\u0644\u064a\u0629 \u0643\u0644 \u0641\u0631\u062f \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0627\u0644\u0643\u0627\u0645\u0644.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1786370214456\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 46 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u064a\u0638\u0647\u0631 \u062d\u0630\u0641\u064c \u064a\u064f\u0634\u0627\u0631 \u0625\u0644\u064a\u0647 \u0628\u0628\u0633\u0627\u0637\u0629 \u0628\u0627\u0633\u0645 &quot;\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 46&quot; \u0641\u064a \u0642\u0648\u0627\u0626\u0645 \u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u062a\u064a \u064a\u064f\u0645\u0643\u0646 \u0646\u0638\u0631\u064a\u0627\u064b \u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0641\u064a\u0647\u0627. \u0645\u0639 \u0630\u0644\u0643\u060c \u064a\u0646\u0628\u063a\u064a \u0645\u0631\u0627\u062c\u0639\u0629 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u0643\u0627\u0645\u0644\u0629 \u0644\u0623\u0646 \u062d\u062f\u0648\u062f \u0627\u0644\u062d\u0630\u0641 \u0648\u062a\u0623\u062b\u064a\u0631\u0627\u062a\u0647\u0627 \u0639\u0644\u0649 \u0625\u0637\u0627\u0631 \u0627\u0644\u0642\u0631\u0627\u0621\u0629 \u0623\u0645\u0631\u064c \u0628\u0627\u0644\u063a \u0627\u0644\u0623\u0647\u0645\u064a\u0629.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1786370222218\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0647\u0644 \u064a\u0645\u0643\u0646 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 46-49 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u0646\u0639\u0645. \u064a\u064f\u0639\u062f \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0645\u0646 46 \u0625\u0644\u0649 49 \u0645\u062b\u0627\u0644\u0627\u064b \u0634\u0627\u0626\u0639\u0627\u064b \u0639\u0644\u0649 \u062d\u0630\u0641 \u062e\u0627\u0631\u062c \u0627\u0644\u0625\u0637\u0627\u0631 \u064a\u0645\u0643\u0646 \u0625\u0646\u0642\u0627\u0630\u0647 \u0639\u0646 \u0637\u0631\u064a\u0642 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1786370242273\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0645\u0627 \u0647\u0648 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u062a\u0627\u062d \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u0643\u0627\u0633\u064a\u0645\u064a\u0631\u0633\u0646 (\u0623\u0645\u0648\u0646\u062f\u064a\u0633 45) \u0647\u0648 \u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f \u0645\u0636\u0627\u062f \u0644\u0644\u062c\u064a\u0646\u0627\u062a \u0645\u0639\u062a\u0645\u062f \u0645\u0646 \u0642\u0628\u0644 \u0644\u062c\u0646\u0629 \u0627\u0644\u0627\u0639\u062a\u0645\u0627\u062f \u0627\u0644\u062f\u0648\u0644\u064a\u0629 (FDA) \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0637\u0641\u0631\u0627\u062a \u0645\u0624\u0643\u062f\u0629 \u0641\u064a \u062c\u064a\u0646 DMD \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062e\u0636\u0648\u0639 \u0644\u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45. \u0648\u0644\u0627 \u064a\u0632\u0627\u0644 \u0627\u0639\u062a\u0645\u0627\u062f\u0647 \u064a\u062e\u0636\u0639 \u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0645\u0639\u062c\u0644\u0629.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1786370250501\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\">\u0647\u0644 \u062a\u0636\u0645\u0646 \u0627\u0644\u0637\u0641\u0631\u0629 \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u062a\u0637\u0628\u064a\u0642 \u0646\u062c\u0627\u062d \u0639\u0645\u0644\u064a\u0629 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u061f<\/h3>\n<div class=\"rank-math-answer\">\n\n<p>\u0644\u0627. \u0645\u0635\u0637\u0644\u062d &quot;\u0642\u0627\u0628\u0644 \u0644\u0644\u0639\u0644\u0627\u062c&quot; \u064a\u0635\u0641 \u0637\u0641\u0631\u0629 \u062c\u064a\u0646\u064a\u0629 \u064a\u064f\u0639\u062f\u0651 \u062d\u0630\u0641 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0644\u0647\u0627. \u0648\u0644\u0627 \u064a\u0636\u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0645\u0635\u0637\u0644\u062d \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u0648 \u0646\u062a\u064a\u062c\u0629 \u0645\u062d\u062f\u062f\u0629. \u064a\u0646\u0628\u063a\u064a \u0627\u062a\u062e\u0627\u0630 \u0642\u0631\u0627\u0631\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u062a\u0634\u0627\u0648\u0631 \u0645\u0639 \u0637\u0628\u064a\u0628 \u0645\u062a\u062e\u0635\u0635 \u0641\u064a \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<h2 id=\"conclusion\" class=\"wp-block-heading\">\u062e\u0627\u062a\u0645\u0629<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u064a\u0645\u062b\u0644 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0627\u0633\u062a\u0631\u0627\u062a\u064a\u062c\u064a\u0629 \u0639\u0644\u0627\u062c\u064a\u0629 \u0645\u0648\u062c\u0647\u0629 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0641\u0631\u0639\u064a\u0629 \u0645\u0646 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a\u060c \u0648\u062a\u062d\u062f\u064a\u062f\u0627\u064b \u0623\u0648\u0644\u0626\u0643 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0639\u0645\u0644\u064a\u0627\u062a \u062d\u0630\u0641 \u062a\u0634\u0645\u0644 \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a 7-44\u060c 12-44\u060c 18-44\u060c 44\u060c 46\u060c 46-47\u060c 46-48\u060c 46-49\u060c 46-51\u060c 46-53\u060c 46-55\u060c 46-57\u060c 46-59\u060c 46-60\u060c 46-67\u060c 46-69\u060c 46-75 \u0623\u0648 46-78.<\/strong> \u0628\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u060c \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0625\u0637\u0627\u0631 \u0642\u0631\u0627\u0621\u0629 \u0627\u0644\u062c\u064a\u0646\u060c \u0645\u0645\u0627 \u064a\u0633\u0645\u062d \u0628\u0625\u0646\u062a\u0627\u062c \u0634\u0643\u0644 \u0645\u0628\u062a\u0648\u0631 \u0648\u0644\u0643\u0646\u0647 \u0641\u0639\u0627\u0644 \u0645\u0646 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646. \u064a\u062d\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u0646\u0647\u062c \u0648\u0639\u062f\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0628\u062a\u062d\u0633\u064a\u0646 \u062c\u0648\u062f\u0629 \u0627\u0644\u062d\u064a\u0627\u0629 \u0648\u0625\u0628\u0637\u0627\u0621 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0644\u062f\u0649 \u0628\u0639\u0636 \u0645\u0631\u0636\u0649 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u062f\u0648\u0634\u064a\u0646\u064a.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0625\u0645\u0643\u0627\u0646\u0627\u062a\u0647\u060c \u0641\u0625\u0646 \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u0644\u064a\u0633 \u062d\u0644\u0627\u064b \u0634\u0627\u0645\u0644\u0627\u064b. \u062a\u0639\u062a\u0645\u062f \u0641\u0639\u0627\u0644\u064a\u062a\u0647 \u0639\u0644\u0649 \u0646\u0648\u0639 \u0627\u0644\u0637\u0641\u0631\u0629 \u0648\u0642\u062f\u0631\u062a\u0647\u0627 \u0639\u0644\u0649 \u0625\u064a\u0635\u0627\u0644 \u0627\u0644\u0623\u0648\u0644\u064a\u063a\u0648\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629. \u0645\u0639 \u062a\u0642\u062f\u0645 \u0627\u0644\u0623\u0628\u062d\u0627\u062b \u0648\u0625\u062c\u0631\u0627\u0621 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0642\u062f \u064a\u0635\u0628\u062d \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646\u0627\u062a \u062c\u0632\u0621\u064b\u0627 \u0623\u0633\u0627\u0633\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u062a\u0631\u0633\u0627\u0646\u0629 \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u062f\u0648\u0634\u064a\u0646\u060c \u0648\u062e\u0627\u0635\u0629\u064b \u0644\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0637\u0641\u0631\u0627\u062a \u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f: <a href=\"https:\/\/dmdwarrior.com\/ar\/next-generation-exon-skipping-therapies-for-duchenne-muscular-dystrophy\/\" target=\"_blank\" data-type=\"post\" data-id=\"2468\" rel=\"noreferrer noopener\">\u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062e\u0637\u064a \u0627\u0644\u0625\u0643\u0633\u0648\u0646 \u0645\u0646 \u0627\u0644\u062c\u064a\u0644 \u0627\u0644\u0642\u0627\u062f\u0645<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>As of recent years, exon skipping has emerged as a promising therapeutic strategy for certain types of mutations in the dystrophin gene. Exon 45 skipping is one of the most investigated strategies for addressing specific mutations in DMD. So, do you wonder the mutations amenable to exon 45 skipping? This approach aims to skip a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3342,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[317,318,319,77,178],"class_list":["post-3338","post","type-post","status-publish","format-standard","has-post-thumbnail","category-dmd","tag-exon-45","tag-exon-45-skipping","tag-exon-45-skipping-therapy","tag-exon-skipping","tag-exon-skipping-therapies"],"subtitle":"\u0642\u062f \u062a\u064f\u0634\u0643\u0651\u0644 \u0627\u0644\u062d\u0630\u0648\u0641\u0627\u062a \u0627\u0644\u0642\u0627\u0628\u0644\u0629 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45 \u0645\u0633\u0627\u0631\u064b\u0627 \u0639\u0644\u0627\u062c\u064a\u064b\u0627 \u0645\u062d\u062a\u0645\u0644\u0627\u064b \u0644\u0628\u0639\u0636 \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a (DMD). \u0648\u0644\u0643\u0646 \u0645\u0627 \u0647\u064a \u0627\u0644\u0637\u0641\u0631\u0627\u062a \u0627\u0644\u0645\u0624\u0647\u0644\u0629\u061f \u062a\u0639\u0631\u0651\u0641 \u0639\u0644\u0649 \u0627\u0644\u062d\u0630\u0648\u0641\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0636\u0645\u0648\u0631 \u062f\u0648\u0634\u064a\u0646 \u0627\u0644\u0639\u0636\u0644\u064a \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0633\u062a\u062c\u064a\u0628 \u0644\u062a\u062c\u0627\u0648\u0632 \u0627\u0644\u0625\u0643\u0633\u0648\u0646 45\u060c \u0648\u0643\u064a\u0641\u064a\u0629 \u062a\u062d\u062f\u064a\u062f\u0647\u0627 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0641\u062d\u0635 \u0627\u0644\u062c\u064a\u0646\u064a.","_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/3338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=3338"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/3338\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/3342"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=3338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=3338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=3338"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}