{"id":2386,"date":"2025-01-10T16:42:40","date_gmt":"2025-01-10T13:42:40","guid":{"rendered":"https:\/\/dmdwarrior.com\/?p=2386"},"modified":"2025-11-03T20:30:56","modified_gmt":"2025-11-03T17:30:56","slug":"plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics","status":"publish","type":"post","link":"https:\/\/dmdwarrior.com\/ar\/plans-for-dyne-101-in-dm1-and-dyne-251-in-dmd-are-announced-by-dyne-therapeutics\/","title":{"rendered":"\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Dyne Therapeutics \u0639\u0646 \u062e\u0637\u0637\u0647\u0627 \u0644\u0640 DYNE-101 \u0641\u064a DM1 \u0648 DYNE-251 \u0641\u064a DMD"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u0623\u0639\u0644\u0646\u062a \u0634\u0631\u0643\u0629 Dyne Therapeutics \u0639\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0633\u0631\u064a\u0631\u064a\u0629 \u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0644\u0639\u0644\u0627\u062c\u0627\u062a\u0647\u0627 DYNE-101 \u0648DYNE-251 \u062e\u0644\u0627\u0644 \u062d\u062f\u062b \u0644\u0644\u0645\u0633\u062a\u062b\u0645\u0631\u064a\u0646 \u0641\u064a 10 \u064a\u0646\u0627\u064a\u0631 2025. \u0623\u0638\u0647\u0631 DYNE-101 \u0644\u0639\u0644\u0627\u062c \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u0627\u0644\u0639\u0636\u0644\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 1 (DM1) \u062a\u0635\u062d\u064a\u062d\u064b\u0627 \u0643\u0628\u064a\u0631\u064b\u0627 \u0644\u0644\u0631\u0628\u0637 \u0648\u062a\u062d\u0633\u064a\u0646\u0627\u062a \u0648\u0638\u064a\u0641\u064a\u0629\u060c \u0645\u0645\u0627 \u062f\u0641\u0639 Dyne \u0625\u0644\u0649 \u0627\u0644\u062a\u062e\u0637\u064a\u0637 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u062a\u0648\u0633\u0639 \u062a\u0633\u062c\u064a\u0644 \u0639\u0627\u0644\u0645\u064a\u0629 \u0644\u062a\u062c\u0631\u0628\u0629 ACHIEVE \u0628\u062c\u0631\u0639\u0629 \u062a\u0633\u062c\u064a\u0644\u064a\u0629 6.8 \u0645\u062c\u0645 \/ \u0643\u062c\u0645 \u0643\u0644 8 \u0623\u0633\u0627\u0628\u064a\u0639 \u0648\u062a\u0642\u062f\u064a\u0645 \u0645\u0648\u0627\u0641\u0642\u0629 \u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0633\u0631\u064a\u0639\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0641\u064a \u0627\u0644\u0646\u0635\u0641 \u0627\u0644\u0623\u0648\u0644 \u0645\u0646 \u0639\u0627\u0645 2026.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0648\u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0646\u0641\u0633\u0647\u060c \u064a\u0633\u0639\u0649 DYNE-251\u060c \u0627\u0644\u0630\u064a \u064a\u0633\u062a\u0647\u062f\u0641 \u0636\u0645\u0648\u0631 \u0627\u0644\u0639\u0636\u0644\u0627\u062a \u062f\u0648\u0634\u064a\u0646 (DMD)\u060c \u0623\u064a\u0636\u064b\u0627 \u0625\u0644\u0649 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0627\u0644\u0633\u0631\u064a\u0639\u0629 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u062f\u064a\u0633\u062a\u0631\u0648\u0641\u064a\u0646 \u0643\u0646\u0642\u0637\u0629 \u0646\u0647\u0627\u064a\u0629 \u0628\u062f\u064a\u0644\u0629\u060c \u0648\u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0623\u0646 \u062a\u062a\u0648\u0641\u0631 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0628\u062d\u0644\u0648\u0644 \u0623\u0648\u0627\u062e\u0631 \u0639\u0627\u0645 2025 \u0644\u062f\u0639\u0645 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0637\u0644\u0628 \u0641\u064a \u0623\u0648\u0627\u0626\u0644 \u0639\u0627\u0645 2026. \u0648\u064a\u0638\u0647\u0631 \u0643\u0644\u0627 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c\u064a\u0646 \u0648\u0639\u062f\u064b\u0627 \u0641\u064a \u062a\u062d\u0648\u064a\u0644 \u0646\u0645\u0627\u0630\u062c \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u0647\u0630\u0647 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f<\/strong>:\u00a0<a href=\"https:\/\/dmdwarrior.com\/ar\/dmd-therapies\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u0627\u0644\u062a\u062c\u0627\u0631\u0628 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0645\u0631\u0636 \u062f\u0648\u0634\u064a\u0646 (\u0642\u0627\u0626\u0645\u0629 \u0628\u062c\u0645\u064a\u0639 \u0627\u0644\u0623\u0628\u062d\u0627\u062b)<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Dyne Therapeutics announced positive clinical data for its therapies DYNE-101 and DYNE-251 during an investor event on January 10, 2025. DYNE-101 for myotonic dystrophy type 1 (DM1) demonstrated significant splicing correction and functional improvements, leading Dyne to plan a global Registrational Expansion Cohort of the ACHIEVE trial with a registrational dose of 6.8 mg\/kg Q8W [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[281],"tags":[118,66,143,144,145],"class_list":["post-2386","post","type-post","status-publish","format-standard","has-post-thumbnail","category-press-releases","tag-duchenne","tag-duchenne-muscular-dystrophy","tag-dyne","tag-dyne-101","tag-dyne-251"],"_links":{"self":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/2386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/comments?post=2386"}],"version-history":[{"count":0,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/posts\/2386\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media\/2388"}],"wp:attachment":[{"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/media?parent=2386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/categories?post=2386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dmdwarrior.com\/ar\/wp-json\/wp\/v2\/tags?post=2386"}],"curies":[{"name":"\u0648\u0648\u0631\u062f\u0628\u0631\u064a\u0633","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}